Molecules, 2006 3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h wereprepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L-and D-amino acid amides 4a-h.
Zrinka Rajic +2 more
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Novel Dual 5-HT7 Antagonists and Sodium Channel Inhibitors as Potential Therapeutic Agents with Antidepressant and Anxiolytic Activities [PDF]
PharmaceuticalsBackground/Objectives: The study aimed to pharmacologically evaluate dually acting ligands, 5-HT7 antagonists and sodium channel inhibitors, as potential therapeutic agents for the treatment of depression, anxiety, and neuropathic pain. The designed dual
Anna Czopek +15 more
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Recent Applications of Hydantoins in Drug Discovery: Updates (2019~Present) [PDF]
MoleculesHydantoins, exemplified by the imidazolidine-2,4-dione core, are privileged scaffolds in medicinal chemistry due to their compact structure, versatile hydrogen-bonding capacity, ability to fine-tune physicochemical properties for drug-like molecules, and
Jyoti Dnyaneshwar Palkhede +3 more
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Design, Synthesis, Bioevaluation, and Bioinformatics Study of 5‐Benzylidene Hydantoin Derivatives as Novel Tyrosine Kinase Inhibitors [PDF]
ChemistryOpenTyrosine kinases regulate cellular growth, differentiation, and metabolism, and their dysregulation is implicated in malignancies, making them therapeutic targets.
Muhammad Naufal +4 more
doaj +2 more sources
Sequential two-step, one-pot microwave-assisted Urech synthesis of 5-monosubstituted hydantoins from L-amino acids in water [PDF]
Beilstein Journal of Organic ChemistryThe hydantoin scaffold is renowned for its wide-ranging biological activities, including antibacterial, antiviral, anticancer, anti-inflammatory, and anticonvulsant effects.
Wei-Jin Chang +3 more
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Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]
Beilstein Journal of Organic ChemistryThe cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
doaj +2 more sources
Preservatives in Leave-On Cosmetics Available on the Dutch Market. [PDF]
Contact DermatitisContact Dermatitis, Volume 94, Issue 5, Page 541-544, May 2026.
de Groot AC, Ipenburg NA, Rustemeyer T.
europepmc +2 more sources
Hydantoins: Synthesis, properties and anticonvulsant activity [PDF]
Hemijska Industrija, 2009 Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical
Trišović Nemanja P. +2 more
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Prevalence of Contact Sensitisation Among Patients With Atopic Dermatitis in Thailand: A 20-Year Retrospective Study. [PDF]
Contact DermatitisContact Dermatitis, Volume 94, Issue 6, Page 689-693, June 2026.
Kanokrungsee S +6 more
europepmc +2 more sources
Inorganics, 2022 Herein, we report the synthesis of platinum(II) complex bearing 3′-aminothiocyclohexanespiro-5′-hydantoin as ligand. The complex was characterized by IR, NMR spectral analyses, elemental analyses and density functional theory (DFT) calculations ...
Emiliya Cherneva +6 more
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