Results 31 to 40 of about 4,502 (179)

Design and Synthesis of New Hydantoin Acetanilide Derivatives as Anti-NSCLC Targeting EGFR^L858R/T790M Mutations

Pharmaceuticals, 2022
Epidermal Growth Factor Receptor (EGFR), its wild type and mutations L858R/T790M, is overexpressed in non-small cell lung cancer (NSCLC) patients and is considered an inevitable oncology target.
Moamen A. Hassanin, Muhamad Mustafa, Mohammed A. S. Abourehab, Heba A. Hassan, Omar M. Aly, Eman A. M. Beshr   +5 more
doaj   +1 more source

Synthesis of hydantoin and thiohydantoin related compounds from benzil and study of their cytotoxicity [PDF]

Bangladesh Journal of Pharmacology, 2006
Condensation of benzil (1) with urea, monophenyl urea and diphenyl urea in the presence of absolute ethanol using 30% aqueous NaOH gave the products 1a, 1b and 1c respectively and also with thiourea, monomethyl thiourea, dimethyl thiourea and diethyl ...
A. Kashem Liton and M. Rabiul Islam
doaj  

3-Methyl-5,5-diphenylimidazolidine-2,4-dione

IUCrData, 2017
In the title molecule, C16H14N2O2, the imidazolidine-2,4-dione ring carries two phenyl substituents at the 5-position inclined to the five-membered ring plane by 59.17 (6) and 53.21 (6)°.
Walid Guerrab, Rachida Akrad, Mhammed Ansar, Jamal Taoufik, Joel T. Mague, Youssef Ramli   +5 more
doaj   +1 more source

Electron-donating Effect of Hydantoin Derivative Inhibitor on the Enhanced Anticorrosion Capacity for Mild Steel in Hydrochloric Acid Medium

International Journal of Electrochemical Science, 2022
Hydantoin (HDT) and its derivative (allantoin, ALT) were evaluated as corrosion inhibitors for 20# steel in 1 M HCl solution at 303 K through gravimetric test, potentiodynamic polarization, electrochemical impedance spectroscopy and surface analysis ...
Junjie Zhu, Hua Hao, Xingwen Zheng
doaj   +1 more source

UV-VIS, Surface Morphology and Electrochemical Study of Cobalt Electrodeposition from Choline Chloride-ethylene Glycol Liquid Mixture

International Journal of Electrochemical Science, 2021
In this report, we present a simple, efficient and promising methodology of electroplating cobalt in the mixture of choline chloride and ethylene glycol in 1:2 mol ratio in the presence of hydantoin (HD) as an additive.
Jamil A. Juma, Wrya O. Karim, Shujahadeen B Aziz   +2 more
doaj   +1 more source

Synthesis and Crystal Structures of 1,1′-Methylene-bis(imidazolidine-2,4-dione) and Alkali Metal Salts

Crystals, 2014
Single-crystal structures of 1,1′-methylenebis(imidazolidine-2,4-dione) and its sodium and dipotassium salts were determined. Powder X-ray diffraction was also employed to characterize the bulk materials and those phases which did not yield single ...
Robert Salchner, Volker Kahlenberg, Roman Lackner, Klaus Wurst, Doris Braun, Gerhard Laus, Herwig Schottenberger   +6 more
doaj   +1 more source

Trifluoromethylated Quinolone-Hydantoin Hybrids: Synthesis and Antibacterial Evaluation

Sci, 2022
A series of new trifluoromethyl-substituted quinolones and hydantoin hybrids has been synthesized and evaluated against Gram-positive bacterium (Staphylococcus aureus MTCC 96) and Gram-negative bacteria (Pseudomonas aeruginosa MTCC 441, Klebsiella ...
Akhil Mahajan, Harbinder Singh, Amandeep Singh, Devendra K. Agrawal, Amandeep Arora, Tejpal Singh Chundawat   +5 more
doaj   +1 more source

Crystal structures of (S)-(+)-5-(3-bromo/chloro-4-isopropoxyphenyl)-5-methylimidazolidine-2,4-dione

Acta Crystallographica Section E: Crystallographic Communications, 2016
In (S)-(+)-5-(3-bromo-4-isopropoxyphenyl)-5-methylimidazolidine-2,4-dione, C13H15BrN2O3, (I), the hydantoin groups are connected via intermolecular N—H...O hydrogen bonds, forming a terraced sheet structure.
Shigeru Ohba, Minoru Koura, Hisashi Sumida, Kimiyuki Shibuya   +3 more
doaj   +1 more source

Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities

Molecules, 2023
In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine ...
Amani Toumi, Faiza I.A. Abdella, Sarra Boudriga, Tahani Y. A. Alanazi, Asma K. Alshamari, Ahlam Abdulrahman Alrashdi, Amal Dbeibia, Khaled Hamden, Ismail Daoud, Michael Knorr, Jan-Lukas Kirchhoff, Carsten Strohmann   +11 more
doaj   +1 more source

5-(4-Fluorophenyl)-5-methylimidazolidine-2,4-dione

Acta Crystallographica Section E, 2008
In the title compound, C10H9FN2O2, the dihedral angle between the hydantoin unit and the benzene ring is 65.55 (5)°. The atoms in the hydantoin ring are coplanar, with a mean deviation of 0.015 Å and a maximum deviation of 0.075 ...
Shahid Hameed, Masahiro Ebihara, M. Khawar Rauf, Abid Hussain, M. Kaleem Kashif   +4 more
doaj   +1 more source