Results 31 to 40 of about 6,701 (204)
Angewandte Chemie, EarlyView.We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li +15 more
wiley +2 more sources
Investigation of the GnRH antagonist degarelix isomerization in biological matrices
Pharmacology Research & Perspectives, 2023 One of the main objectives of peptide drug design is the improvement of peptide pharmacokinetics with maintaining biological activity, which can be achieved by the complex modifications of the primary structure of the peptides.
Lucia Ferrazzano +6 more
doaj +1 more source
Angewandte Chemie, EarlyView.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +2 more sources
SYNTHESIS AND CHARACTERIZATION OF COMPLEX DIAQUADIHYDANTOIN NICKEL(II) SULFAT MONOHIDRAT)
Alchemy, 2016 The purpose of the research is to find out the synthesis, formula and characteristic of complex of Nickel(II) with hydantoin (hyd). Complex of nickel(II) with hydantoin have been synthesized in 1 : 1 mole ratio of metal to ligan in methanol.The formula
Sentot Budi Rahardjo +2 more
doaj +1 more source
Drug-Induced Changes in the Gingival Tissue
Journal of Interdisciplinary Medicine, 2023 Drug-induced gingivitis is caused by the administration of certain drugs such as hydantoin, calcium blockers, beta-blockers, cyclosporine, and oral contraceptives.
Kis Estella +2 more
doaj +1 more source
Acta Crystallographica Section E, 2010 In the asymmetric unit of the title organic–inorganic hybrid material, 2{H3[PW12O40]}·4C3H4N2O2·C7H8N4O4·21.5H2O, there are four crystallographically independent hydantoin molecules, one dimerized hydantoin molecule ...
Mohammad Hasan Alizadeh +1 more
doaj +1 more source
Synthesis of series of different imidazolidine-2,4-dione derivatives and evaluation of their antimicrobial potential [PDF]
Kragujevac Journal of Science, 2022 A series of twenty two different imidazolidine-2,4-dione derivatives, divided according to their structure into five groups, including alkyl, alkenyl or aryl 5,5disubstituted hydantoins, spirohydantoins, and fused bicyclic and tricyclic hydantoins, was ...
Šmit Biljana +5 more
doaj +1 more source
The Pyroglutamate Hydantoin Rearrangement [PDF]
European Journal of Organic Chemistry, 2006 Abstract When a mixture of a pyroglutamate and an isocyanate in THF is treated with NaH, a ring transformation occurs leading to functionalised hydantoins. The novel reaction involves a ring‐closing ring‐opening sequence providing a new and straightforward access to an interesting class of heterocyclic compounds. Furthermore, starting
Nicolai Dieltiens +6 more
openaire +1 more source
Molecules, 2011 2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a–n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding 2-(methylthio)-1H-imidazol-5(4H)-ones 3a–c with suitably substituted secondary amines.
Edward R. Biehl +2 more
doaj +1 more source