Design, Synthesis, Bioevaluation, and Bioinformatics Study of 5‐Benzylidene Hydantoin Derivatives as Novel Tyrosine Kinase Inhibitors [PDF]
ChemistryOpenTyrosine kinases regulate cellular growth, differentiation, and metabolism, and their dysregulation is implicated in malignancies, making them therapeutic targets.
Muhammad Naufal +4 more
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3-(4-Chlorophenylsulfonyl)-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione [PDF]
Acta Crystallographica Section E, 2009 In the title compound, C15H17ClN2O4S, the atoms in the hydantoin ring are coplanar (r.m.s. deviation = 0.006 Å). The crystal structure is stabilized by intermolecular N—H...O hydrogen bonds which link the molecules into ...
M. Kalim Kashif +3 more
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Novel Lipophilic Hydroxamates Based on Spirocarbocyclic Hydantoin Scaffolds with Potent Antiviral and Trypanocidal Activity [PDF]
Pharmaceuticals, 2023 Flaviviridae infections, such as those caused by hepatitis C (HCV) and dengue viruses (DENVs), represent global health risks. Infected people are in danger of developing chronic liver failure or hemorrhagic fever, both of which can be fatal if not ...
Vasiliki Pardali +8 more
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Novel Dual 5-HT7 Antagonists and Sodium Channel Inhibitors as Potential Therapeutic Agents with Antidepressant and Anxiolytic Activities [PDF]
PharmaceuticalsBackground/Objectives: The study aimed to pharmacologically evaluate dually acting ligands, 5-HT7 antagonists and sodium channel inhibitors, as potential therapeutic agents for the treatment of depression, anxiety, and neuropathic pain. The designed dual
Anna Czopek +15 more
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Recent Applications of Hydantoins in Drug Discovery: Updates (2019~Present) [PDF]
MoleculesHydantoins, exemplified by the imidazolidine-2,4-dione core, are privileged scaffolds in medicinal chemistry due to their compact structure, versatile hydrogen-bonding capacity, ability to fine-tune physicochemical properties for drug-like molecules, and
Jyoti Dnyaneshwar Palkhede +3 more
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Molecules, 2006 3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h wereprepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L-and D-amino acid amides 4a-h.
Zrinka Rajić +2 more
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Noncyanide Silver Plating Solution Using Hydantoin and Hydantoin Derivatives.
Journal of the Surface Finishing Society of Japan, 1999 We studied silver-hydantoin noncyanide silver plating solution to determine the effect of potassium chloride, potassium sulfite, and potassium thiosulfate on deposit appearance using SEM imaging, brightness, and X-ray diffraction.We also studied the effects of hydantoin, 1-methylhydantoin, and 5, 5-dimethylhydantoin on limiting current density using a ...
Takanobu ASAKAWA, Somei YARITA
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Sequential two-step, one-pot microwave-assisted Urech synthesis of 5-monosubstituted hydantoins from L-amino acids in water [PDF]
Beilstein Journal of Organic ChemistryThe hydantoin scaffold is renowned for its wide-ranging biological activities, including antibacterial, antiviral, anticancer, anti-inflammatory, and anticonvulsant effects.
Wei-Jin Chang +3 more
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Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]
Beilstein Journal of Organic ChemistryThe cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
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