The Bucherer–Bergs Multicomponent Synthesis of Hydantoins—Excellence in Simplicity [PDF]
Molecules, 2021 Hydantoins and their hybrids with other molecules represent a very important group of heterocycles because they exhibit diverse biological and pharmacological activities in medicinal and agrochemical applications. They also serve as key precursors in the
Maroš Bella +2 more
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Recent Applications of Hydantoins in Drug Discovery: Updates (2019~Present) [PDF]
MoleculesHydantoins, exemplified by the imidazolidine-2,4-dione core, are privileged scaffolds in medicinal chemistry due to their compact structure, versatile hydrogen-bonding capacity, ability to fine-tune physicochemical properties for drug-like molecules, and
Jyoti Dnyaneshwar Palkhede +3 more
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Phase-Transfer-Catalyzed Alkylation of Hydantoins [PDF]
ACS Organic & Inorganic Au, 2022 Stellios Arséniyadis, Alexandre Jean
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Sequential two-step, one-pot microwave-assisted Urech synthesis of 5-monosubstituted hydantoins from L-amino acids in water [PDF]
Beilstein Journal of Organic ChemistryThe hydantoin scaffold is renowned for its wide-ranging biological activities, including antibacterial, antiviral, anticancer, anti-inflammatory, and anticonvulsant effects.
Wei-Jin Chang +3 more
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N-Alkylhydantoins as New Organogelators and Their Ability to Create Thixotropic Mixed Molecular Organogels [PDF]
Gels, 2022 The author reported molecular organogels using N-alkylhydantoins as new low-molecular-weight gelators for the first time, and thixotropic mixed molecular organogels using a set of N-alkylhydantoin gelators with different alkyl chain lengths.
Yutaka Ohsedo
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Synthesis, Absolute Configuration, Biological Profile and Antiproliferative Activity of New 3,5-Disubstituted Hydantoins [PDF]
PharmaceuticalsHydantoins, a class of five-membered heterocyclic compounds, exhibit diverse biological activities. The aim of this study was to synthesize and characterize a series of novel 3,5-disubstituted hydantoins and to investigate their antiproliferative ...
Mladenka Jurin +8 more
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Synthesis and Evaluation of 5-(Heteroarylmethylene)hydantoins as Glycogen Synthase Kinase-3β Inhibitors [PDF]
PharmaceuticalsGlycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase which plays a center role in the phosphorylation of a wide variety of proteins, generally leading to their inactivation. As such, GSK-3 is viewed as a therapeutic target.
Nicholas O. Schneider +4 more
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Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]
Beilstein Journal of Organic ChemistryThe cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
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Synthesis, carbonic anhydrase inhibition studies and modelling investigations of phthalimide–hydantoin hybrids [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryA novel series of hydantoins incorporating phthalimides has been synthesised by condensation of activated phthalimides with 1-aminohydantoin and investigated for their inhibitory activity against a panel of human (h) carbonic anhydrase (CA, EC 4.2.1.1 ...
Morteza Abdoli +4 more
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Skeletal rearrangement in Biginelli reaction for the synthesis of chromenoquinoline fused spirohydantoins and their in silico cytotoxicity study [PDF]
Scientific ReportsAlthough Biginelli reaction is known to generate dihydropyrimidinones having wide arrays of phramacological properties, herein we report an unprecedented skeletal rearrangement in Biginelli reaction to synthesize pharmacologically versatile imidazolidine-
Mezhubeinuo +3 more
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