The Bucherer–Bergs Multicomponent Synthesis of Hydantoins—Excellence in Simplicity [PDF]
Molecules, 2021 Hydantoins and their hybrids with other molecules represent a very important group of heterocycles because they exhibit diverse biological and pharmacological activities in medicinal and agrochemical applications. They also serve as key precursors in the
Martin Kalnik +2 more
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Sequential two-step, one-pot microwave-assisted Urech synthesis of 5-monosubstituted hydantoins from L-amino acids in water [PDF]
Beilstein Journal of Organic ChemistryThe hydantoin scaffold is renowned for its wide-ranging biological activities, including antibacterial, antiviral, anticancer, anti-inflammatory, and anticonvulsant effects.
Wei-Jin Chang +3 more
doaj +3 more sources
Phase-Transfer-Catalyzed Alkylation of Hydantoins [PDF]
ACS Organic & Inorganic Au, 2022 A highly efficient, cost-effective, and environmentally friendly protocol is reported for the C5-selective alkylation of hydantoins under phase-transfer catalysis.
Thomas Keenan +2 more
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Synthesis, Absolute Configuration, Biological Profile and Antiproliferative Activity of New 3,5-Disubstituted Hydantoins [PDF]
PharmaceuticalsHydantoins, a class of five-membered heterocyclic compounds, exhibit diverse biological activities. The aim of this study was to synthesize and characterize a series of novel 3,5-disubstituted hydantoins and to investigate their antiproliferative ...
Mladenka Jurin +8 more
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Influence of electrochemical conditions on the regio- and stereoselectivity of selenocyclization of alkenyl hydantoins [PDF]
Journal of the Serbian Chemical Society, 2021 5-Alkenyl hydantoins and alkenyl spirohydantoins are converted into bicyclic and tricyclic hydantoins, under indirect electrochemical conditions, generating the phenylselenyl cation in situ. The reactions proceeded in good to exelent yields.
Šmit Biljana M. +4 more
doaj +2 more sources
Recent Applications of Hydantoins in Drug Discovery: Updates (2019~Present) [PDF]
MoleculesHydantoins, exemplified by the imidazolidine-2,4-dione core, are privileged scaffolds in medicinal chemistry due to their compact structure, versatile hydrogen-bonding capacity, ability to fine-tune physicochemical properties for drug-like molecules, and
Jyoti Dnyaneshwar Palkhede +3 more
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N-Alkylhydantoins as New Organogelators and Their Ability to Create Thixotropic Mixed Molecular Organogels [PDF]
Gels, 2022 The author reported molecular organogels using N-alkylhydantoins as new low-molecular-weight gelators for the first time, and thixotropic mixed molecular organogels using a set of N-alkylhydantoin gelators with different alkyl chain lengths.
Yutaka Ohsedo
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Separations, 2022 The enantioseparation of syn- and anti-3,5-disubstituted hydantoins 5a–i was investigated on three immobilized polysaccharide-based columns (CHIRAL ART Amylose-SA, CHIRAL ART Cellulose-SB, CHIRAL ART Cellulose-SC) by high performance liquid ...
Mladenka Jurin +3 more
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Synthesis and Evaluation of 5-(Heteroarylmethylene)hydantoins as Glycogen Synthase Kinase-3β Inhibitors [PDF]
PharmaceuticalsGlycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase which plays a center role in the phosphorylation of a wide variety of proteins, generally leading to their inactivation. As such, GSK-3 is viewed as a therapeutic target.
Nicholas O. Schneider +4 more
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Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance. [PDF]
ChemistryThis review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Dolcini L +3 more
europepmc +2 more sources