Results 41 to 50 of about 2,171 (198)

Base-Promoted Solid-Phase Synthesis of Substituted Hydantoins and Thiohydantoins

, 2016
Base-Promoted Solid-Phase Synthesis of Substituted Hydantoins and ...
Jay Matthews (3040941), Ralph A. Rivero (1993048)   +1 more
core   +2 more sources

Revisiting the Urech Synthesis of Hydantoins: Direct Access to Enantiopure 1,5-Substituted Hydantoins Using Cyanobenziodoxolone [PDF]

A method for the synthesis of enantiopure 1,5-substituted hydantoins was developed using a hypervalent iodine cyanation reagent (cyanobenziodoxolone, CBX) as a source of electrophilic carbon.
Declas, Nina, Waser, Jerome, Le Vaillant, Franck   +2 more
core   +1 more source

Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1

Angewandte Chemie International Edition, EarlyView.
We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li, Marie E. Perrin, Emma Maillard, Arthur Vitard, Gwenaëlle Moal, Johanne Mbianda, Christophe André, Magda Teixeira Nunes, Marie Vandamme, Guillaume Pinna, Céline Douat, Emmanuelle Thinon, Raphaël Guerois, Pierre Legrand, Gilles Guichard, Francoise Ochsenbein   +15 more
wiley   +1 more source

Hydantoins Derived from Ketopinic and 4-camphorcarboxylic Acids [PDF]

, 2013
Diastereospecific formation of hydantoins from ketopinic and 4-camphorcarboxylic acids under Bucherer-Bergs reaction conditions has been investigated.
Voitenko, Zoia, Knizhnikov, Volodymyr, Gorichko, Marian   +2 more
core   +1 more source

Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold

Beilstein Journal of Organic Chemistry, 2012
Dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives were prepared by successive N3- and N1-alkylation of hydantoins, followed by regioselective thionation and subsequent cyclization under mild conditions.
Nikolay T. Tzvetkov, Harald Euler, Christa E. Müller   +2 more
doaj   +1 more source

Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives

Molecules, 2009
Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products.
José Alixandre de Sousa Luis, José Maria Barbosa Filho, Bruno Freitas Lira, Isac Almeida Medeiros, Liana Clébia Soares Lima de Morais, Alexsandro Fernandes dos Santos, Cledualdo Soares de Oliveira, Petrônio Filgueiras de Athayde-Filho   +7 more
doaj   +1 more source

The mechanism of racemisation of 5-substituted hydantoins in aqueous solution [PDF]

This thesis describes our studies of the racemisation of substituted hydantoins and is divided in six chapters. Chapter 1 presents the concepts of chirality and racemisation and its implications in drug development.
Narduolo, Stefania
core   +6 more sources

Structural Control of Dual Emission in Coumarin Fluorophores for Visualizing Protein Droplet Maturation

Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.
A coumarin‐based dual‐emission fluorophore was designed to visualize the maturation of protein liquid droplets. Upon covalent conjugation to droplet‐forming proteins, ratiometric fluorescence imaging allowed real time monitoring of droplet maturation. This probe is applicable to the analysis of droplet formation and maturation mechanisms, as well as to
Tomoya Yamamoto, Yusei Otsuka, Asuka Mori, Yuichiro Hori, Yuma Yamamoto, Motonari Uesugi, Kazuya Kikuchi   +6 more
wiley   +2 more sources

Reversible Cystine Disulfide Scaffolding Enables Carbonyl Sulfide‐Mediated Intramolecular Peptide Bond Formation via Cyclocystine: Implications for Prebiotic Chemistry

Chemistry – A European Journal, EarlyView.
Cystine is unique among amino acids, in that the disulfide bond can allow intramolecular peptide bond formation. This cyclization offers potential advantages for intramolecular coupling selectivity in prebiotic peptide formation. ABSTRACT Treatment of cystine (the disulfide‐linked dimer of cysteine) with carbonyl sulfide (COS) results in the formation ...
Avinash Vicholous Dass, Arthur Srayeddin, Anthony Rullo, Jonathan Stone, Maikel Rheinstadter, Paul Harrison   +5 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source