Results 41 to 50 of about 1,978 (203)
Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 1, 3-bis-substituted-5, 5-dimethylhydantoins [PDF]
Journal of the Serbian Chemical Society, 2003 A series of 1,3-bis-substituted-5,5-dimethylhydantoins was synthesized using the reaction of 5,5-dimethylhydantoin with the corresponding alkyl halide in the presence of trimethylamine as catalyst and sodium hydroxide, according to a modified literature ...
Ušćumlić Gordana S. +2 more
doaj +3 more sources
New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways. [PDF]
PLoS ONE, 2011 BACKGROUND: Oxidative damage to DNA, if not repaired, can be both miscoding and blocking. These genetic alterations can lead to mutations and/or cell death, which in turn cause cancer and aging.
Modesto Redrejo-Rodríguez +6 more
doaj +1 more source
, 2019 A method for the synthesis of enantiopure 1,5-substituted hydantoins was developed using a hypervalent iodine cyanation reagent (cyanobenziodoxolone, CBX) as a source of electrophilic carbon.
Franck Le Vaillant (3211635) +2 more
core +1 more source
Cu-catalyzed N‑3-Arylation of Hydantoins Using Diaryliodonium Salts
, 2020 A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu ...
Alexander H. Sandtorv +7 more
core +1 more source
Mechanochemical Amidation Mediated by 1,1’‐Oxalyldiimidazole for the Synthesis of Agrochemicals
Chemistry – A European Journal, EarlyView.Mechanochemical amidation using 1,1'‐oxalyldiimidazole (ODI) overcomes limitations of 1,1’‐carbonyl diimidazole (CDI) as coupling agent by enabling the efficient mechanochemical synthesis of three marketed agrochemicals from deactivated carboxylic acids.
Andrea Casagrande +6 more
wiley +1 more source
New route for 1-substituted hydantoins [PDF]
, 1965 Alkytation reactions on hydantoins (I) lead smoothly to 3-alkyl derivatives; more rigorous conditions allow further substitution at position 1 provided the N1-H group is activated by an aryl group or an ethylenic bond attached to the adjacent C52,a.
Corral, Renée Antonio +1 more
core +2 more sources
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2012 Dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives were prepared by successive N3- and N1-alkylation of hydantoins, followed by regioselective thionation and subsequent cyclization under mild conditions.
Nikolay T. Tzvetkov +2 more
doaj +1 more source
Molecules, 2009 Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products.
José Alixandre de Sousa Luis +7 more
doaj +1 more source
Smart Molecules, EarlyView.Inverse Diels‐Alder Cycloaddition Reaction was developed for ultrasensitive miR‐21 detection. Based on the enhanced Through‐Bond Energy Transfer and catalytic amplification, it shows a detection limit of 3.58 × 10−18 M and 100 aM–100 nM linear range. It enables high‐contrast cell/tissue imaging and distinguishes lung cancer patients in serum, promising
Yikun Li +10 more
wiley +1 more source