Results 41 to 50 of about 1,234 (170)

Mechanochemical Amidation Mediated by 1,1’‐Oxalyldiimidazole for the Synthesis of Agrochemicals

Chemistry – A European Journal, EarlyView.
Mechanochemical amidation using 1,1'‐oxalyldiimidazole (ODI) overcomes limitations of 1,1’‐carbonyl diimidazole (CDI) as coupling agent by enabling the efficient mechanochemical synthesis of three marketed agrochemicals from deactivated carboxylic acids.
Andrea Casagrande, Rubén Solorzano‐Rodriguez, Maria Carta, Francesco Delogu, Joris Vezzani, Allan Niidu, Evelina Colacino   +6 more
wiley   +1 more source

Making sense of chemical space network shows signs of criticality

Scientific Reports, 2023
Chemical space modelling has great importance in unveiling and visualising latent information, which is critical in predictive toxicology related to drug discovery process.
Nicola Amoroso, Nicola Gambacorta, Fabrizio Mastrolorito, Maria Vittoria Togo, Daniela Trisciuzzi, Alfonso Monaco, Ester Pantaleo, Cosimo Damiano Altomare, Fulvio Ciriaco, Orazio Nicolotti   +9 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Rechargeable N‐Halamine Functionalized Ultra‐Thin PES Ultrafiltration Membranes

Journal of Polymer Science, EarlyView.
An automated 3D printer‐assisted casting platform is utilized to fabricate ultra‐thin polyethersulfone membranes with precise structural control. The integration of a custom‐synthesized, regenerable N‐halamine homopolymer imparts superior, cyclic antifouling resistance and rapid, broad‐spectrum antibacterial efficacy.
Ahmet Aydın, Fatma Demirci, Hasan Basri Kocer   +2 more
wiley   +1 more source

Enhanced through‐bond energy transfer‐based bioorthogonal probe enables catalytic‐amplified and sensitive detection of microRNA‐21 for clinical lung cancer diagnosis

Smart Molecules, EarlyView.
Inverse Diels‐Alder Cycloaddition Reaction was developed for ultrasensitive miR‐21 detection. Based on the enhanced Through‐Bond Energy Transfer and catalytic amplification, it shows a detection limit of 3.58 × 10−18 M and 100 aM–100 nM linear range. It enables high‐contrast cell/tissue imaging and distinguishes lung cancer patients in serum, promising
Yikun Li, Fuping Han, Haiqiao Huang, Danhong Zhou, Saran Long, Wen Sun, Jianjun Du, Jiangli Fan, Jing Ning, Chong Peng, Xiaojun Peng   +10 more
wiley   +1 more source

Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins

Beilstein Journal of Organic Chemistry, 2017
The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG).
Andrea Mascitti, Massimiliano Lupacchini, Ruben Guerra, Ilya Taydakov, Lucia Tonucci, Nicola d’Alessandro, Frederic Lamaty, Jean Martinez, Evelina Colacino   +8 more
doaj   +1 more source

Methylchloroisothiazolinone and Methylisothiazolinone 10 Years After Regulation: A Case Story of Liquid Soaps and Shampoos

Contact Dermatitis, EarlyView.
MCI/MI and MI contact allergy remain persistent. In this analysis of the Danish market, 257 products containing MCI/MI or MI were identified, and 30 products were analysed. Two exceeded regulatory limits, while most complied, suggesting current limits may require further investigation. Created in BioRender. Pedersen, M. K.
Mathias Krogh Pedersen, Jakob Ferløv Baselius Schwensen, Jose Hernán Alfonso, Christel Søgaard Kirkeby, Stine Müller, Steen Mollerup, Gianluca Selvestrel, Christina Rudén, Martin F. Wilks, Jeanne Duus Johansen   +9 more
wiley   +1 more source

Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators

Journal of Chemistry, 2018
Spiroconnected N-alkoxyalkylpiperidine hydantoins were obtained via the Strecker reaction of cyanohydrin with ammonium carbonate. 1,3,8-Triazaspiro[4.5]decane-2,4-diones have shown the myelostimulating activity in the artificially induced (with ...
Valentina Yu, Assel Ten, Lyailya Baktybayeva, Indira Sagatbekova, Kaldybay Praliyev, Darya Zolotareva, Tulegen Seilkhanov, Alexey Zazybin   +7 more
doaj   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins

Beilstein Journal of Organic Chemistry, 2018
A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary ...
Robby Vroemans, Fante Bamba, Jonas Winters, Joice Thomas, Jeroen Jacobs, Luc Van Meervelt, Jubi John, Wim Dehaen   +7 more
doaj   +1 more source