Hydantoins: Synthesis, properties and anticonvulsant activity [PDF]
Hemijska Industrija, 2009 Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical
Trišović Nemanja P. +2 more
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Pulsed Fe Electro-Oxidation for Catalytic Synthesis of Hydantoin Derivatives
International Journal of Electrochemical Science, 2016 This paper presents an original and practical organic electrochemical/chemical (EC/C) synthesis to prepare hydantoin derivatives from N-Alkyl-piperidin-4-ones.
S. Santiago-Ruiz +3 more
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The Pyroglutamate Hydantoin Rearrangement [PDF]
European Journal of Organic Chemistry, 2006 Abstract When a mixture of a pyroglutamate and an isocyanate in THF is treated with NaH, a ring transformation occurs leading to functionalised hydantoins. The novel reaction involves a ring‐closing ring‐opening sequence providing a new and straightforward access to an interesting class of heterocyclic compounds. Furthermore, starting
Nicolai Dieltiens +6 more
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Synthesis, structure and biological properties of active spirohydantoin derivatives [PDF]
Hemijska Industrija, 2016 Spirohidantoins represent an pharmacologically important class of heterocycles since many derivatives have been recognized that display interesting activities against a wide range of biological targets.
Lazić Anita M. +4 more
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Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts
, 2020 A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu ...
Sandtorv, Alexander Harald +3 more
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Biologically Oriented Hybrids of Indole and Hydantoin Derivatives
Molecules, 2023 Indoles and hydantoins are important heterocycles scaffolds which present in numerous bioactive compounds which possess various biological activities. Moreover, they are essential building blocks in organic synthesis, particularly for the preparation of ...
Konstantin A. Kochetkov +2 more
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Lipophilicity assessment of some 5,5-disubstituted hydantoins by the means of reversed phase liquid chromatography [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2013 The retention of some 5,5-disubstituted hydantoins was investigated by reversed phase high performance thin-layer chromatography (RP HPTLC) and reversed phase high-pressure liquid chromatography (RP HPLC).
Despotović Vesna +4 more
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New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways. [PDF]
PLoS ONE, 2011 BACKGROUND: Oxidative damage to DNA, if not repaired, can be both miscoding and blocking. These genetic alterations can lead to mutations and/or cell death, which in turn cause cancer and aging.
Modesto Redrejo-Rodríguez +6 more
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Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 1, 3-bis-substituted-5, 5-dimethylhydantoins [PDF]
Journal of the Serbian Chemical Society, 2003 A series of 1,3-bis-substituted-5,5-dimethylhydantoins was synthesized using the reaction of 5,5-dimethylhydantoin with the corresponding alkyl halide in the presence of trimethylamine as catalyst and sodium hydroxide, according to a modified literature ...
Ušćumlić Gordana S. +2 more
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, 2019 A method for the synthesis of enantiopure 1,5-substituted hydantoins was developed using a hypervalent iodine cyanation reagent (cyanobenziodoxolone, CBX) as a source of electrophilic carbon.
Franck Le Vaillant (3211635) +2 more
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