Results 11 to 20 of about 1,234 (170)

Sustainable purification-free synthesis of N–H ketimines by solid acid catalysis [PDF]

Nature Communications
Among imines, nitrogen-unprotected ketimines (N–H ketimines) are valuable precursors to nitrogen-containing compounds. However, their applications are limited compared with those of nitrogen-protected ketimines (N–R ketimines) owing to difficulties in ...
Shintaro Shibata, Makoto Onaka
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Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities [PDF]

Molecules, 2023
In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine ...
Amani Toumi, Faiza I.A. Abdella, Sarra Boudriga, Tahani Y. A. Alanazi, Asma K. Alshamari, Ahlam Abdulrahman Alrashdi, Amal Dbeibia, Khaled Hamden, Ismail Daoud, Michael Knorr, Jan-Lukas Kirchhoff, Carsten Strohmann   +11 more
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Spirohydantoin derivatives exert dopamine D2-like receptor-independent cytotoxicity in glioblastoma cells with possible involvement of calpain inhibition [PDF]

Scientific Reports
Glioblastoma multiforme (GBM) maintains one of the most aggressive brain tumor with increasing resistance. Herein in vitro study investigates spirohydantoin derivatives with diversified dopamine D2R-like affinity as potential anti-glioblastoma agents ...
Katarzyna Kucwaj-Brysz, Sabina Podlewska, Klaudia Jakubowska, Aleksandra Mąsior, Michał Wilczkowski, Beata Duszyńska, Justyna Drukała, Jadwiga Handzlik, Danuta Jantas   +8 more
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Influence of electrochemical conditions on the regio- and stereoselectivity of selenocyclization of alkenyl hydantoins [PDF]

Journal of the Serbian Chemical Society, 2021
5-Alkenyl hydantoins and alkenyl spirohydantoins are converted into bicyclic and tricyclic hydantoins, under indirect electrochemical conditions, generating the phenylselenyl cation in situ. The reactions proceeded in good to exelent yields.
Šmit Biljana M., Stanić Petar B., Joksović Ljubinka G., Ašanin Darko P., Simić Zoran   +4 more
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Enantioseparation of syn- and anti-3,5-Disubstituted Hydantoins by HPLC and SFC on Immobilized Polysaccharides-Based Chiral Stationary Phases

Separations, 2022
The enantioseparation of syn- and anti-3,5-disubstituted hydantoins 5a–i was investigated on three immobilized polysaccharide-based columns (CHIRAL ART Amylose-SA, CHIRAL ART Cellulose-SB, CHIRAL ART Cellulose-SC) by high performance liquid ...
Mladenka Jurin, Darko Kontrec, Tonko Dražić, Marin Roje   +3 more
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Synthesis of series of different imidazolidine-2,4-dione derivatives and evaluation of their antimicrobial potential [PDF]

Kragujevac Journal of Science, 2022
A series of twenty two different imidazolidine-2,4-dione derivatives, divided according to their structure into five groups, including alkyl, alkenyl or aryl 5,5disubstituted hydantoins, spirohydantoins, and fused bicyclic and tricyclic hydantoins, was ...
Šmit Biljana, Radojević Ivana, Stanić Petar B., Ašanin Darko, Vasić Marijana, Katanić-Stanković Jelena S.   +5 more
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Synthesis, structure and solvatochromism of 5-methyl-5-(3- or 4-substituted phenyl)hydantoins [PDF]

Journal of the Serbian Chemical Society, 2009
Several 5-methyl-5-(3- or 4-substituted phenyl)hydantoins were prepared and their ultraviolet absorption spectra were recorded in the region 200–400 nm in twelve solvents of different polarity. The effect of solvent dipo¬larity/polarizability and solvent/
NATALIJA D. DIVJAK, NEBOJŠA R. BANJAC, NATAŠA V. VALENTIĆ, GORDANA S. UŠĆUMLIĆ   +3 more
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Hydantoin and hydrogen-bonding patterns in hydantoin derivatives [PDF]

Acta Crystallographica Section C Crystal Structure Communications, 2004
The structure of hydantoin (imidazolidine-2,4-dione), C3H4N2O2, has been determined from a twinned crystal. The two carbonyl bond lengths are nearly equal, even though one of them adjoins electron-donating NH groups to either side while the other is adjacent to only one.
Yu, Fang-Lei, Schwalbe, Carl H., Watkin, David J.   +2 more
openaire   +3 more sources

Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus aureus Strains

Antibiotics, 2023
In this study, a search for new therapeutic agents that may improve the antibacterial activity of conventional antibiotics and help to successfully overcome methicillin-resistant Staphylococcus aureus (MRSA) infections has been conducted.
Karolina Witek, Aneta Kaczor, Ewa Żesławska, Sabina Podlewska, Małgorzata Anna Marć, Kinga Czarnota-Łydka, Wojciech Nitek, Gniewomir Latacz, Waldemar Tejchman, Markus Bischoff, Claus Jacob, Jadwiga Handzlik   +11 more
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Thermochemical Study of 1-Methylhydantoin

Molecules, 2022
Using static bomb combustion calorimetry, the combustion energy of 1-methylhydantoin was obtained, from which the standard molar enthalpy of formation of the crystalline phase at T = 298.15 K of the compound studied was calculated.
Juan M. Ledo, Henoc Flores, Fernando Ramos, Elsa A. Camarillo   +3 more
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