Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities. [PDF]
Molecules, 2023 In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine ...
Toumi A +13 more
europepmc +2 more sources
Sustainable purification-free synthesis of N-H ketimines by solid acid catalysis. [PDF]
Nat CommunAmong imines, nitrogen-unprotected ketimines (N–H ketimines) are valuable precursors to nitrogen-containing compounds. However, their applications are limited compared with those of nitrogen-protected ketimines (N–R ketimines) owing to difficulties in ...
Shibata S, Onaka M.
europepmc +2 more sources
Influence of electrochemical conditions on the regio- and stereoselectivity of selenocyclization of alkenyl hydantoins [PDF]
Journal of the Serbian Chemical Society, 2021 5-Alkenyl hydantoins and alkenyl spirohydantoins are converted into bicyclic and tricyclic hydantoins, under indirect electrochemical conditions, generating the phenylselenyl cation in situ. The reactions proceeded in good to exelent yields.
Šmit Biljana M. +4 more
doaj +1 more source
Phase-Transfer-Catalyzed Alkylation of Hydantoins. [PDF]
ACS Org Inorg Au, 2022 Keenan T, Jean A, Arseniyadis S.
europepmc +2 more sources
Separations, 2022 The enantioseparation of syn- and anti-3,5-disubstituted hydantoins 5a–i was investigated on three immobilized polysaccharide-based columns (CHIRAL ART Amylose-SA, CHIRAL ART Cellulose-SB, CHIRAL ART Cellulose-SC) by high performance liquid ...
Mladenka Jurin +3 more
doaj +1 more source
Synthesis of series of different imidazolidine-2,4-dione derivatives and evaluation of their antimicrobial potential [PDF]
Kragujevac Journal of Science, 2022 A series of twenty two different imidazolidine-2,4-dione derivatives, divided according to their structure into five groups, including alkyl, alkenyl or aryl 5,5disubstituted hydantoins, spirohydantoins, and fused bicyclic and tricyclic hydantoins, was ...
Šmit Biljana +5 more
doaj +1 more source
Synthesis, structure and solvatochromism of 5-methyl-5-(3- or 4-substituted phenyl)hydantoins [PDF]
Journal of the Serbian Chemical Society, 2009 Several 5-methyl-5-(3- or 4-substituted phenyl)hydantoins were prepared and their ultraviolet absorption spectra were recorded in the region 200–400 nm in twelve solvents of different polarity. The effect of solvent dipo¬larity/polarizability and solvent/
NATALIJA D. DIVJAK +3 more
doaj +3 more sources
A Cross-Sectional Study of Contact Allergens in Hotel Personal Care Products in Canada, the United States and Europe. [PDF]
Contact DermatitisThis study provides evidence of contact allergens in commonly provided hotel personal care products. Patients and clinicians should advocate for improved labelling of contact allergens in hotel personal care products. Additionally, hotels should offer low‐allergen alternatives for at‐risk guests.
Viltakis V, Kirchhof MG.
europepmc +2 more sources
Antibiotics, 2023 In this study, a search for new therapeutic agents that may improve the antibacterial activity of conventional antibiotics and help to successfully overcome methicillin-resistant Staphylococcus aureus (MRSA) infections has been conducted.
Karolina Witek +11 more
doaj +1 more source
Revisiting the SAR of the antischistosomal aryl hydantoin (Ro 13-3978) [PDF]
, 2016 The aryl hydantoin 1 (Ro 13-3978) was identified in the early 1980s as a promising antischistosomal lead compound. However, this series of aryl hydantoins produced antiandrogenic side effects in the host, a not unexpected outcome given their close ...
Charman, Susan A. +13 more
core +6 more sources