Combinatorial chemistry of hydantoins
Bioorganic & Medicinal Chemistry Letters, 1998 Access to combinatorial chemistry of hydantoins is provided by convenient and versatile methods for the solid phase synthesis of libraries of 3,5-, 1,3- and 1,3,5-substituted hydantoins.
Kruijtzer, J.A.W +2 more
core +4 more sources
Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]
Beilstein Journal of Organic ChemistryThe cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
doaj +2 more sources
A Sustainable, Semi‐Continuous Flow Synthesis of Hydantoins
Chemistry - A European Journal, 2016 Hydantoins are an important class of heterocycles with applications in pharmacy, agriculture, and as intermediates in organic synthesis. Traditional synthetic procedures to access hydantoins are target oriented with multiple synthetic steps, often use ...
Beate Koksch +2 more
exaly +2 more sources
Anti-Inflammatory Activity of Cyclic Imide Derivatives [PDF]
PharmaceuticalsImide derivatives constitute an interesting group of compounds exhibiting broad biological activity. Structures containing the imide moiety [–CO–N(R)–CO–] occur in both natural and synthetic compounds.
Aleksandra Redzicka +2 more
doaj +2 more sources
Synthesis, carbonic anhydrase inhibition studies and modelling investigations of phthalimide–hydantoin hybrids [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryA novel series of hydantoins incorporating phthalimides has been synthesised by condensation of activated phthalimides with 1-aminohydantoin and investigated for their inhibitory activity against a panel of human (h) carbonic anhydrase (CA, EC 4.2.1.1 ...
Morteza Abdoli +4 more
doaj +2 more sources
Enantioselective synthesis of hydantoins by chiral acid-catalysed condensation of glyoxals and ureas. [PDF]
Chem Sci, 2023 Hydantoins are important scaffolds in natural products and pharmaceuticals, with only a few synthetic strategies available for their asymmetric preparation.
Aryal S, Hone CA, Polson MIJ, Foley DJ.
europepmc +2 more sources
Facile synthesis of hydantoins and thiohydantoins in aqueous solution
Tetrahedron Letters, 2011 A series of hydantoins and thiohydantoins have been synthesized in water at room temperature from urea (or N-methylurea, or thiourea) and simple aldehydes (as glyoxal, and its simple derivatives) in the presence of phosphoric anhydride. The reaction time
Graziano Baccolini +2 more
exaly +2 more sources
Sustainable purification-free synthesis of N–H ketimines by solid acid catalysis [PDF]
Nature CommunicationsAmong imines, nitrogen-unprotected ketimines (N–H ketimines) are valuable precursors to nitrogen-containing compounds. However, their applications are limited compared with those of nitrogen-protected ketimines (N–R ketimines) owing to difficulties in ...
Shintaro Shibata, Makoto Onaka
doaj +2 more sources
Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities [PDF]
Molecules, 2023 In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine ...
Amani Toumi +11 more
doaj +2 more sources
Spirohydantoin derivatives exert dopamine D2-like receptor-independent cytotoxicity in glioblastoma cells with possible involvement of calpain inhibition [PDF]
Scientific ReportsGlioblastoma multiforme (GBM) maintains one of the most aggressive brain tumor with increasing resistance. Herein in vitro study investigates spirohydantoin derivatives with diversified dopamine D2R-like affinity as potential anti-glioblastoma agents ...
Katarzyna Kucwaj-Brysz +8 more
doaj +2 more sources