Results 11 to 20 of about 2,171 (198)

Influence of electrochemical conditions on the regio- and stereoselectivity of selenocyclization of alkenyl hydantoins [PDF]

Journal of the Serbian Chemical Society, 2021
5-Alkenyl hydantoins and alkenyl spirohydantoins are converted into bicyclic and tricyclic hydantoins, under indirect electrochemical conditions, generating the phenylselenyl cation in situ. The reactions proceeded in good to exelent yields.
Šmit Biljana M., Stanić Petar B., Joksović Ljubinka G., Ašanin Darko P., Simić Zoran   +4 more
doaj   +2 more sources

Anti-Inflammatory Activity of Cyclic Imide Derivatives [PDF]

Pharmaceuticals
Imide derivatives constitute an interesting group of compounds exhibiting broad biological activity. Structures containing the imide moiety [–CO–N(R)–CO–] occur in both natural and synthetic compounds.
Aleksandra Redzicka, Beata Tylińska, Anna Wójcicka   +2 more
doaj   +2 more sources

Sustainable purification-free synthesis of N–H ketimines by solid acid catalysis [PDF]

Nature Communications
Among imines, nitrogen-unprotected ketimines (N–H ketimines) are valuable precursors to nitrogen-containing compounds. However, their applications are limited compared with those of nitrogen-protected ketimines (N–R ketimines) owing to difficulties in ...
Shintaro Shibata, Makoto Onaka
doaj   +2 more sources

Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities [PDF]

Molecules, 2023
In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine ...
Amani Toumi, Faiza I.A. Abdella, Sarra Boudriga, Tahani Y. A. Alanazi, Asma K. Alshamari, Ahlam Abdulrahman Alrashdi, Amal Dbeibia, Khaled Hamden, Ismail Daoud, Michael Knorr, Jan-Lukas Kirchhoff, Carsten Strohmann   +11 more
doaj   +2 more sources

Spirohydantoin derivatives exert dopamine D2-like receptor-independent cytotoxicity in glioblastoma cells with possible involvement of calpain inhibition [PDF]

Scientific Reports
Glioblastoma multiforme (GBM) maintains one of the most aggressive brain tumor with increasing resistance. Herein in vitro study investigates spirohydantoin derivatives with diversified dopamine D2R-like affinity as potential anti-glioblastoma agents ...
Katarzyna Kucwaj-Brysz, Sabina Podlewska, Klaudia Jakubowska, Aleksandra Mąsior, Michał Wilczkowski, Beata Duszyńska, Justyna Drukała, Jadwiga Handzlik, Danuta Jantas   +8 more
doaj   +2 more sources

Enantioseparation of syn- and anti-3,5-Disubstituted Hydantoins by HPLC and SFC on Immobilized Polysaccharides-Based Chiral Stationary Phases

Separations, 2022
The enantioseparation of syn- and anti-3,5-disubstituted hydantoins 5a–i was investigated on three immobilized polysaccharide-based columns (CHIRAL ART Amylose-SA, CHIRAL ART Cellulose-SB, CHIRAL ART Cellulose-SC) by high performance liquid ...
Mladenka Jurin, Darko Kontrec, Tonko Dražić, Marin Roje   +3 more
doaj   +1 more source

Synthesis of series of different imidazolidine-2,4-dione derivatives and evaluation of their antimicrobial potential [PDF]

Kragujevac Journal of Science, 2022
A series of twenty two different imidazolidine-2,4-dione derivatives, divided according to their structure into five groups, including alkyl, alkenyl or aryl 5,5disubstituted hydantoins, spirohydantoins, and fused bicyclic and tricyclic hydantoins, was ...
Šmit Biljana, Radojević Ivana, Stanić Petar B., Ašanin Darko, Vasić Marijana, Katanić-Stanković Jelena S.   +5 more
doaj   +1 more source

Synthesis, structure and solvatochromism of 5-methyl-5-(3- or 4-substituted phenyl)hydantoins [PDF]

Journal of the Serbian Chemical Society, 2009
Several 5-methyl-5-(3- or 4-substituted phenyl)hydantoins were prepared and their ultraviolet absorption spectra were recorded in the region 200–400 nm in twelve solvents of different polarity. The effect of solvent dipo¬larity/polarizability and solvent/
NATALIJA D. DIVJAK, NEBOJŠA R. BANJAC, NATAŠA V. VALENTIĆ, GORDANA S. UŠĆUMLIĆ   +3 more
doaj   +3 more sources

The synthesis of 5-substituted hydantoins [PDF]

, 2008
The Bucherer-Bergs reaction is a classical multi-component reaction that yields hydantoins, which can be hydrolysed to afford α-amino acids. Hydantoins have many uses in modern organic synthesis, and this moiety has been included in a number of ...
Murray, Ross George
core   +3 more sources

Hydantoin and hydrogen-bonding patterns in hydantoin derivatives [PDF]

Acta Crystallographica Section C Crystal Structure Communications, 2004
The structure of hydantoin (imidazolidine-2,4-dione), C3H4N2O2, has been determined from a twinned crystal. The two carbonyl bond lengths are nearly equal, even though one of them adjoins electron-donating NH groups to either side while the other is adjacent to only one.
Yu, Fang-Lei, Schwalbe, Carl H., Watkin, David J.   +2 more
openaire   +3 more sources