Results 41 to 50 of about 13,210 (268)
Synthesis of series of different imidazolidine-2,4-dione derivatives and evaluation of their antimicrobial potential [PDF]
Kragujevac Journal of Science, 2022 A series of twenty two different imidazolidine-2,4-dione derivatives, divided according to their structure into five groups, including alkyl, alkenyl or aryl 5,5disubstituted hydantoins, spirohydantoins, and fused bicyclic and tricyclic hydantoins, was ...
Šmit Biljana +5 more
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Identification of a novel class of autotaxin inhibitors through cross-screening [PDF]
, 2015 Three novel series were generated in order to mimic the pharmacophoric features displayed by lead compound AM095, a Lysophosphatidic acid (LPA1) receptor antagonist. Biological evaluation of this array of putative LPA1 antagonists led us to the discovery
Budd, David C. +8 more
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Molecules, 2011 2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a–n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding 2-(methylthio)-1H-imidazol-5(4H)-ones 3a–c with suitably substituted secondary amines.
Edward R. Biehl +2 more
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The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII).
Aleksandrs Pustenko +6 more
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Pharmaceuticals, 2022 Epidermal Growth Factor Receptor (EGFR), its wild type and mutations L858R/T790M, is overexpressed in non-small cell lung cancer (NSCLC) patients and is considered an inevitable oncology target.
Moamen A. Hassanin +5 more
doaj +1 more source
A new Nearctic species of Placonotus MacLeay (Coleoptera: Laemophloeidae) [PDF]
, 2011 Placonotus falinorum Thomas, new species (Coleoptera: Laemophloeidae), is described from Kansas. Habitus and genitalic details are illustrated and the species is distinguished from other New World members of the genus.
Thomas, Michael C.
core +2 more sources
Synthesis of hydantoin and thiohydantoin related compounds from benzil and study of their cytotoxicity [PDF]
Bangladesh Journal of Pharmacology, 2006 Condensation of benzil (1) with urea, monophenyl urea and diphenyl urea in the presence of absolute ethanol using 30% aqueous NaOH gave the products 1a, 1b and 1c respectively and also with thiourea, monomethyl thiourea, dimethyl thiourea and diethyl ...
A. Kashem Liton and M. Rabiul Islam
doaj
3-Methyl-5,5-diphenylimidazolidine-2,4-dione
IUCrData, 2017 In the title molecule, C16H14N2O2, the imidazolidine-2,4-dione ring carries two phenyl substituents at the 5-position inclined to the five-membered ring plane by 59.17 (6) and 53.21 (6)°.
Walid Guerrab +5 more
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Trifluoromethylated Quinolone-Hydantoin Hybrids: Synthesis and Antibacterial Evaluation
Sci, 2022 A series of new trifluoromethyl-substituted quinolones and hydantoin hybrids has been synthesized and evaluated against Gram-positive bacterium (Staphylococcus aureus MTCC 96) and Gram-negative bacteria (Pseudomonas aeruginosa MTCC 441, Klebsiella ...
Akhil Mahajan +5 more
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Effects of formulation on microbicide potency and mitigation of the development of bacterial insusceptibility [PDF]
, 2015 Risk assessments of the potential for microbicides to select for reduced bacterial susceptibility have been based largely on data generated through the exposure of bacteria to microbicides in aqueous solution.
Amézquita, Alejandro +6 more
core +1 more source