Results 41 to 50 of about 4,496 (180)

Mechanochemical Amidation Mediated by 1,1’‐Oxalyldiimidazole for the Synthesis of Agrochemicals

Chemistry – A European Journal, EarlyView.
Mechanochemical amidation using 1,1'‐oxalyldiimidazole (ODI) overcomes limitations of 1,1’‐carbonyl diimidazole (CDI) as coupling agent by enabling the efficient mechanochemical synthesis of three marketed agrochemicals from deactivated carboxylic acids.
Andrea Casagrande, Rubén Solorzano‐Rodriguez, Maria Carta, Francesco Delogu, Joris Vezzani, Allan Niidu, Evelina Colacino   +6 more
wiley   +1 more source

Exploring hydantoin frameworks: synthetic approaches and therapeutic potential

Future Journal of Pharmaceutical Sciences
Background Since its first synthesis in the nineteenth century, hydantoin has emerged as a vital scaffold in drug development, especially for anticonvulsant, antimicrobial, antitumor, and anti-inflammatory agents.
Nirmala V. Shinde, Vrushali P. Patole, Manoj R. Kumbhare, Harsha Narkhede, Ashwini T. Satalkar, Anushka V. Thube, Sachin K. Bhosale   +6 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Fetal Hydantoin Syndrome

Pediatric Neurology Briefs, 1990
In a prospective study of 19 pregnancies monitored by amniocentesis at the Center for Human Genetics and the Meyer Rehabilitation Institute, University of Nebraska, Omaha, an adverse outcome was predicted for four fetuses on the basis of low epoxide ...
J Gordon Millichap
doaj   +1 more source

Enhanced through‐bond energy transfer‐based bioorthogonal probe enables catalytic‐amplified and sensitive detection of microRNA‐21 for clinical lung cancer diagnosis

Smart Molecules, EarlyView.
Inverse Diels‐Alder Cycloaddition Reaction was developed for ultrasensitive miR‐21 detection. Based on the enhanced Through‐Bond Energy Transfer and catalytic amplification, it shows a detection limit of 3.58 × 10−18 M and 100 aM–100 nM linear range. It enables high‐contrast cell/tissue imaging and distinguishes lung cancer patients in serum, promising
Yikun Li, Fuping Han, Haiqiao Huang, Danhong Zhou, Saran Long, Wen Sun, Jianjun Du, Jiangli Fan, Jing Ning, Chong Peng, Xiaojun Peng   +10 more
wiley   +1 more source

Estrutura, reatividade e propriedades biológicas de hidantoínas Structure, reactivity, and biological properties of hidantoines

Química Nova, 2008
Hydantoin (imidazolidine-2,4-dione) is a 2,4-diketotetrahydroimidazole discovered by Baeyer in 1861. Thiohydantoins and derivatives were prepared, having chemical properties similar to the corresponding carbonyl compounds.
Silvânia Maria de Oliveira, João Bosco Paraíso da Silva, Marcelo Zaldini Hernandes, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta   +5 more
doaj   +1 more source

The Prevalence of Contact Allergy to Formaldehyde and Formaldehyde Releasers: A Systematic Review and Meta‐Analysis

Contact Dermatitis, EarlyView.
ABSTRACT Formaldehyde and its releasers are common preservatives and potent sensitizers. This meta‐analysis aimed to estimate the prevalence of formaldehyde contact allergy and allergy to its five most common releasers among dermatitis patients. Two authors independently searched PubMed, Embase, and Web of Science from inception to 30th September 2025.
Kian Karimian, Daniel Isufi, Mikkel Bak Jensen, Rebekka Søgaard, Jeanne Duus Johansen, Jakob Ferløv Baselius Schwensen   +5 more
wiley   +1 more source

Synthesis, crystal structure and Hirshfeld surface analysis of 5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione

Acta Crystallographica Section E: Crystallographic Communications
The new phenytoin analogue 5,5-diphenyl-3-(2-propyn-1-yl)imidazolidine-2,4-dione, C18H14N2O2 (3), was obtained through an alkylation reaction with propargyl bromide via the phase-transfer catalysis method, and its structure was determined via single ...
Abderrazzak El Moutaouakil Ala Allah, Chiara Massera, Walid Guerrab, Abdulsalam Alsubari, Joel T. Mague, Youssef Ramli   +5 more
doaj   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Effect of New 2-Thioxoimidazolidin-4-one Compounds against Staphylococcus aureus Clinical Strains and Immunological Markers’ Combinations

Canadian Journal of Infectious Diseases and Medical Microbiology, 2022
Although the structure-activity relationship indicates that the 4-thioxoimidazolidin ring is essential for antibacterial activities and pharmaceutical applications, there were no enough studies on the derivatives of this compound.
Hanan Tariq Subhi, Hiwa Ramadhan Fatah, Hanaa Ali Muhammad   +2 more
doaj   +1 more source