Results 41 to 50 of about 6,701 (204)

The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The clinically used antibiotic Furagin and its derivatives possess inhibitory activity on human (h) carbonic anhydrases (CA, EC 4.2.1.1), some of which are highly expressed in various tissues and malignancies (hCA IX/XII).
Aleksandrs Pustenko, Alessio Nocentini, Paola Gratteri, Alessandro Bonardi, Igor Vozny, Raivis Žalubovskis, Claudiu T. Supuran   +6 more
doaj   +1 more source

Synthesis of hydantoin and thiohydantoin related compounds from benzil and study of their cytotoxicity [PDF]

Bangladesh Journal of Pharmacology, 2006
Condensation of benzil (1) with urea, monophenyl urea and diphenyl urea in the presence of absolute ethanol using 30% aqueous NaOH gave the products 1a, 1b and 1c respectively and also with thiourea, monomethyl thiourea, dimethyl thiourea and diethyl ...
A. Kashem Liton and M. Rabiul Islam
doaj  

3-Methyl-5,5-diphenylimidazolidine-2,4-dione

IUCrData, 2017
In the title molecule, C16H14N2O2, the imidazolidine-2,4-dione ring carries two phenyl substituents at the 5-position inclined to the five-membered ring plane by 59.17 (6) and 53.21 (6)°.
Walid Guerrab, Rachida Akrad, Mhammed Ansar, Jamal Taoufik, Joel T. Mague, Youssef Ramli   +5 more
doaj   +1 more source

Design and Synthesis of New Hydantoin Acetanilide Derivatives as Anti-NSCLC Targeting EGFR^L858R/T790M Mutations

Pharmaceuticals, 2022
Epidermal Growth Factor Receptor (EGFR), its wild type and mutations L858R/T790M, is overexpressed in non-small cell lung cancer (NSCLC) patients and is considered an inevitable oncology target.
Moamen A. Hassanin, Muhamad Mustafa, Mohammed A. S. Abourehab, Heba A. Hassan, Omar M. Aly, Eman A. M. Beshr   +5 more
doaj   +1 more source

Electron-donating Effect of Hydantoin Derivative Inhibitor on the Enhanced Anticorrosion Capacity for Mild Steel in Hydrochloric Acid Medium

International Journal of Electrochemical Science, 2022
Hydantoin (HDT) and its derivative (allantoin, ALT) were evaluated as corrosion inhibitors for 20# steel in 1 M HCl solution at 303 K through gravimetric test, potentiodynamic polarization, electrochemical impedance spectroscopy and surface analysis ...
Junjie Zhu, Hua Hao, Xingwen Zheng
doaj   +1 more source

Hydantoin-Substituted 4,6-Dichloroindole-2-carboxylic Acids as Ligands with High Affinity for the Glycine Binding Site of the NMDA Receptor^§

, 2016
A novel series of C-3 substituted 4,6-dichloroindole-2-carboxylic acids was synthesized to investigate the influence of different hydrogen-bond donor and acceptor groups at this specific position on the affinity to the glycine site of the NMDA receptor ...
Michaela Jansen (474213), Gerd Dannhardt (2424877), Claudia Brandt (374198), Wolfgang Löscher (519911), Heidrun Potschka (710542)   +4 more
core   +1 more source

Synthesis and Crystal Structures of 1,1′-Methylene-bis(imidazolidine-2,4-dione) and Alkali Metal Salts

Crystals, 2014
Single-crystal structures of 1,1′-methylenebis(imidazolidine-2,4-dione) and its sodium and dipotassium salts were determined. Powder X-ray diffraction was also employed to characterize the bulk materials and those phases which did not yield single ...
Robert Salchner, Volker Kahlenberg, Roman Lackner, Klaus Wurst, Doris Braun, Gerhard Laus, Herwig Schottenberger   +6 more
doaj   +1 more source

UV-VIS, Surface Morphology and Electrochemical Study of Cobalt Electrodeposition from Choline Chloride-ethylene Glycol Liquid Mixture

International Journal of Electrochemical Science, 2021
In this report, we present a simple, efficient and promising methodology of electroplating cobalt in the mixture of choline chloride and ethylene glycol in 1:2 mol ratio in the presence of hydantoin (HD) as an additive.
Jamil A. Juma, Wrya O. Karim, Shujahadeen B Aziz   +2 more
doaj   +1 more source

FTIR spectroscopic and quantum chemical studies on hydantoin

, 2012
In this study the geometry optimization of monomeric and dimeric forms (D1, D2, and D3) of hydantoin molecule were done using DFT method employing 6-31++G(d, p) basis set.
Ildiz, Gulce Ogruc, Unsalan, Ozan, Boz, Ismail   +2 more
core   +3 more sources

Crystal structures of (S)-(+)-5-(3-bromo/chloro-4-isopropoxyphenyl)-5-methylimidazolidine-2,4-dione

Acta Crystallographica Section E: Crystallographic Communications, 2016
In (S)-(+)-5-(3-bromo-4-isopropoxyphenyl)-5-methylimidazolidine-2,4-dione, C13H15BrN2O3, (I), the hydantoin groups are connected via intermolecular N—H...O hydrogen bonds, forming a terraced sheet structure.
Shigeru Ohba, Minoru Koura, Hisashi Sumida, Kimiyuki Shibuya   +3 more
doaj   +1 more source