Results 61 to 70 of about 4,496 (180)
Propyl-2-(8-(3,4-difluorobenzyl)-2',5'-dioxo-8-azaspiro[bicyclo[3.2.1] octane-3,4'-imidazolidine]-1'-yl) acetate induces apoptosis in human leukemia cells through mitochondrial pathway following cell cycle arrest. [PDF]
PLoS ONE, 2013 BACKGROUND: Due to the functional defects in apoptosis signaling molecules or deficient activation of apoptosis pathways, leukemia has become an aggressive disease with poor prognosis.
Chandagirikoppal V Kavitha +8 more
doaj +1 more source
Contact Dermatitis, Volume 94, Issue 5, Page 515-523, May 2026.The overall prevalence of sensitization to FA/FRs was 1.9% (48/2592). ACD was diagnosed in 37.5% (18/48), comprising non‐occupational ACD (83.3%) and occupational ACD (16.7%). FA 1%–2% aq. failed to detect FR sensitisation in 31.9% (n = 15/47) and FR‐induced ACD in 35.3% (n = 6/17) of patients.
Esen Özkaya +2 more
wiley +1 more source
RESEARCHES ON HYDANTOINS. SYNTHESIS OF THE SOPORIFIC, 4,4-PHENYLETHYL-HYDANTOIN(NIRVANOL) [PDF]
Journal of the American Chemical Society, 1922 n ...
openaire +2 more sources
Advanced Functional Materials, Volume 36, Issue 28, 7 April 2026.A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya +14 more
wiley +1 more source
Molecules, 2018 This study focuses on the design, synthesis, biological evaluation, and computer-aided structure-activity relationship (SAR) analysis for a novel group of aromatic triazine-methylpiperazines, with an hydantoin spacer between 1,3,5-traizine and the ...
Rafał Kurczab +15 more
doaj +1 more source
Saudi Pharmaceutical Journal, 2020 In this study, a series of synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives as a potential antiproliferative and antimigratory agents were investigated. The possible antitumor mechanisms of investigated hydantoin derivatives
Ana Obradović +7 more
doaj +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.Selective late‐stage modification of N‐terminal phenylalanine short peptides is achived by visible‐light initiated reaction with N‐iodoimides in a debenzylation–amination process. This metal‐free method permits the incorporation of N‐containing heterocycles into the α‐position of the peptide backbone.
Guillermo Morales‐Ortega +4 more
wiley +1 more source
Chemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.High‐energy proton irradiation of a formamide–diaminomaleonitrile–glycine system in the presence of meteorites produces a broad spectrum of biogenic compounds, including nucleobases, nucleosides, peptides, and nucleobase–peptide conjugates, highlighting a chemically plausible prebiotic network.
Bruno Mattia Bizzarri +6 more
wiley +1 more source
Microbial Biotechnology, Volume 19, Issue 3, March 2026.We engineered thermo‐alkali‐stable D‐hydantoinases via mutagenesis (M63A/F65H/C317T) to resolve Pregabalin's challenging chiral splitting, achieving ee value > 97% for key intermediate (R)‐3‐isobutylglutaric acid monoamide (R‐IBM) synthesis under extreme conditions (pH 10, 70°C–80°C).
Jiujiuzi Zhang +5 more
wiley +1 more source
Contact Dermatitis, Volume 94, Issue 3, Page 272-285, March 2026.Allergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Mercè Grau‐Pérez +29 more
wiley +1 more source