Results 71 to 80 of about 6,701 (204)

A Review on the Some Biological Activities of the Hydantoin Derivatives: . [PDF]

, 2023
Hydantoin derivatives are commonly used anticonvulsants. In general, they are effective for partial-onset seizures and tonic-clonic seizures, but not for absence seizures. Phenytoin is the most important drug in this group, and other drugs, ethotoin, and
Wadghane, Somnath, Rathod, Pooja, Shinde, Ganesh, Bhor, Rohit, Kolhe, Mahesh   +4 more
core   +1 more source

From o‐Phenylenediamine to Flavin Derivatives: A Potential Prebiotic Carbon Skeleton Expansion With Formaldehyde, Cyanide, and CO2

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A Strecker‐type reaction of aromatic ortho‐diamines with various aldehydes and cyanide assembles the bicyclic amidine core of flavin‐derived heterocycles under mild conditions. Subsequent oxidation, radical or photochemical cyanation, carboxylation with CO2, and CO2‐mediated cyclization build the three‐ring alloxazine scaffold. This sequence provides a
Christian Held, Rodrigo José da Silva Lima, Ji‐Woong Lee   +2 more
wiley   +1 more source

Facile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea

Beilstein Journal of Organic Chemistry, 2019
A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed.
Aleksandr I. Kobelev, Nikita A. Tretyakov, Ekaterina E. Stepanova, Maksim V. Dmitriev, Michael Rubin, Andrey N. Maslivets   +5 more
doaj   +1 more source

Tuning crystal packing and reactivity through electrostatic and dispersion interactions: The case of phenytoin and its derivatives [PDF]

Journal of the Serbian Chemical Society
Hydantoin derivatives represent a versatile class of heterocycles, known for their pharmacological properties. Because drug efficacy often depends on the fine-tuning of weak intermolecular (non-covalent) interactions, analysis of the crystal structure of
Đorđević Ivana S., Grubišić Sonja, Mitić Dragana, Popović Dragan M., Trišović Nemanja   +4 more
doaj   +1 more source

Propyl-2-(8-(3,4-difluorobenzyl)-2',5'-dioxo-8-azaspiro[bicyclo[3.2.1] octane-3,4'-imidazolidine]-1'-yl) acetate induces apoptosis in human leukemia cells through mitochondrial pathway following cell cycle arrest. [PDF]

PLoS ONE, 2013
BACKGROUND: Due to the functional defects in apoptosis signaling molecules or deficient activation of apoptosis pathways, leukemia has become an aggressive disease with poor prognosis.
Chandagirikoppal V Kavitha, Mridula Nambiar, Pavan B Narayanaswamy, Elizabeth Thomas, Ujjwal Rathore, Channapillekoppalu S Ananda Kumar, Bibha Choudhary, Kanchugarakoppal S Rangappa, Sathees C Raghavan   +8 more
doaj   +1 more source

SYNTHESIS, REACTIONS, AND APPLICATIONS OF HYDANTOIN AND 2-THIOHYDANTOIN DERIVATIVES [PDF]

, 2019
On account of the interesting pharmacological properties of hydantoin and 2-thiohydantoin derivatives, and other purposes such as textile printing, catalysts for polymerizations, their use in the production of resins and plastics, they have been the ...
Al-Shareef, Hossa F., El-mekawy, Rasha, Abd Elhady, Hebe, El Desoky, Somia   +3 more
core   +1 more source

Machine Learning Paradigm for Advanced Battery Electrolyte Development

Carbon Energy, Volume 8, Issue 8, August 2026.
Electrolyte materials determine ion transport kinetics within the bulk and interphases, ultimately influencing the performance of battery systems. As data‐driven paradigms increasingly reshape materials discovery, this review provides an application‐oriented exploration of the intersection between machine learning and electrolyte science. By evaluating
Chang Su, Mengfan Pei, Keyu Chen, Xigao Jian, Fangyuan Hu   +4 more
wiley   +1 more source

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

, 2017
Hydantoin (imidazolidinedione) derivatives such as nitrofurantoin are small molecules that have aroused considerable interest recently due to their low rate of bacterial resistance.
Hu, Yong, Xia, Donglin, Nimmagadda, Alekhya, Cao, Annie, Ma Su, Peng Teng, Su, Ma, Yong Hu, Jianfeng Cai, Odom, Timothy, Chao Zhang, Annie Cao, Zhang, Chao, Teng, Peng, Donglin Xia, Timothy Odom, Cai, Jianfeng, Alekhya Nimmagadda   +17 more
core   +1 more source

Antiproliferative and antimigratory effects of 3-(4-substituted benzyl)-5- isopropyl-5-phenylhydantoin derivatives in human breast cancer cells

Saudi Pharmaceutical Journal, 2020
In this study, a series of synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives as a potential antiproliferative and antimigratory agents were investigated. The possible antitumor mechanisms of investigated hydantoin derivatives
Ana Obradović, Miloš Matić, Branka Ognjanović, Predrag Đurđević, Emilija Marinković, Gordana Ušćumlić, Bojan Božić, Biljana Božić Nedeljković   +7 more
doaj   +1 more source

RESEARCHES ON HYDANTOINS. SYNTHESIS OF THE SOPORIFIC, 4,4-PHENYLETHYL-HYDANTOIN(NIRVANOL) [PDF]

Journal of the American Chemical Society, 1922
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openaire   +2 more sources