Results 71 to 80 of about 4,496 (180)
Beilstein Journal of Organic Chemistry, 2019 A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed.
Aleksandr I. Kobelev +5 more
doaj +1 more source
Comparative metabolism of hydantoin and beta-methyl hydantoin.
Experimental Biology and Medicine, 1926 In previous experiments1 it was pointed out that when betamethyl hydantoin is given subcutaneously to dogs only fifteen per cent of the compound reappears unchanged in the urine. A similar amount is excreted as methyl hydantoic acid. But while all of the nitrogen of the compound was excreted, the remainder was unaccounted for in the nitrogen partition.
openaire +1 more source
ChemistryEurope, Volume 4, Issue 2, February 2026.In this work, 1,4‐benzodiazepine‐2‐ones are synthesized starting from Kobayashi‐type aryne precursors and amino acid‐derived, unsymmetrical imides. Operationally simple protocols to access both the starting materials and the potential active pharmaceutical ingredients are presented.
Jasper Mindner +5 more
wiley +1 more source
Tuning crystal packing and reactivity through electrostatic and dispersion interactions: The case of phenytoin and its derivatives [PDF]
Journal of the Serbian Chemical SocietyHydantoin derivatives represent a versatile class of heterocycles, known for their pharmacological properties. Because drug efficacy often depends on the fine-tuning of weak intermolecular (non-covalent) interactions, analysis of the crystal structure of
Đorđević Ivana S. +4 more
doaj +1 more source
3-Amino-5-methyl-5-(4-pyridyl)hydantoin
Acta Crystallographica Section E, 2009 The title compound, 3-amino-5-methyl-5-(4-pyridyl)imidazolidine-2,4-dione, C9H10N4O2, was obtained by reaction of 5-methyl-5-(4-pyridyl)hydantoin with hydrazine.
Alexander Roller +3 more
doaj +1 more source
3’-Methyl-4-thio-1H-tetrahydropyranspiro-5’-hydantoin platinum complex as a novel deoxyribonuclease I inhibitor [PDF]
PharmaciaDeoxyribonuclease I (DNase I) is one of the main nucleases involved in deoxyribonucleic acid (DNA) degradation during apoptosis. It catalyzes the hydrolytic cleavage of DNA, producing 5‘-oligonucleotides.
Ana Marković +5 more
doaj +3 more sources
Pulsed Fe Electro-Oxidation for Catalytic Synthesis of Hydantoin Derivatives
International Journal of Electrochemical Science, 2016 This paper presents an original and practical organic electrochemical/chemical (EC/C) synthesis to prepare hydantoin derivatives from N-Alkyl-piperidin-4-ones.
S. Santiago-Ruiz +3 more
doaj +1 more source
Acta Crystallographica Section E: Crystallographic CommunicationsIn the title molecule, C21H17N3O2, the five-membered ring is slightly ruffled and dihedral angles between the pendant six-membered rings and the central, five-membered ring vary between 50.78 (4) and 86.78 (10)°.
Abderrazzak El Moutaouakil Ala Allah +5 more
doaj +1 more source