Results 231 to 240 of about 41,140 (322)

FMRP‐Mediated Proteasome Regulation: A Novel Mechanism in ALS Pathology

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Schematic model of TDP‐43/TNKS‐mediated proteasome regulation in WT, FMRP‐depleted, and TDP‐43A315T‐Tg ALS neurons. In WT neurons, cytoplasmic TDP‐43 partially sequesters TNKS, maintaining balanced PI31 ribosylation and proteasome activity. FMRP depletion promotes nuclear translocation of TDP‐43, enhances TNKS/PI31 interaction, and increases axonal ...
Pritha Majumder, Asmar Ahsan, Pitchapa Bubphachat, Khadiza Akter, Jeffrey K. Huang, Chi‐Chen Sarah Huang   +5 more
wiley   +1 more source

Access to Fluorene-Fused Isoquinolones Containing an Axially Chiral Element via Cascade Bi-Annulation Reaction of Indene-Dienes. [PDF]

Precis Chem
Zhao Y, Deng YH, Yu MY, Zhang YF, He W, Zhang CB, Han QX, Fu JY.   +7 more
europepmc   +1 more source

Discovery of <i>bis</i>-thiourea derivatives as potent tyrosinase inhibitors: combined experimental and computational study. [PDF]

J Enzyme Inhib Med Chem
Sabuakham S, Nasoontorn S, Nuramrum N, Silsirivanit A, Rungrotmongkol T, Pingaew R, Mahalapbutr P.   +6 more
europepmc   +1 more source

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, Volume 32, Issue 25, 2 July 2026.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Synthesis, characterization, <i>in vitro</i> and <i>in silico</i> studies of novel lophine clubbed acylthioureas. [PDF]

RSC Adv
Ullah SA, Jabeen H, Javed A, Manan A, Irshad N, Khan KM, Khushal A, Khan S, Farooq U, Bashir K, Saeed A.   +10 more
europepmc   +1 more source

Disubstituted thiourea as a suitable sulfur source in the gram-scale synthesis of yellow- and red-emitting CdTeS/Cd _x Zn_1-x S core/shell quantum dots. [PDF]

Nanoscale Adv
Loghina L, Houdek J, Slang S, Frumarova B, Cieslar M, Vlcek M.   +5 more
europepmc   +1 more source

Urea-sugar and thiourea-sugar diastereomers: synthesis, crystal structure and biological activities. [PDF]

Future Med Chem
Işilar Ö, Bulut A, Tombul M, Güner A, Şahin O.   +4 more
europepmc   +1 more source

Efficient synthesis of N-(ethylcarbamothioyl)-1-naphthamide: X-ray structure, Hirshfeld surface analysis, DFTs, and molecular modelling investigations as selective inhibitor of alkaline phosphatase. [PDF]

BMC Chem
Channar PA, Alshahrani MY, Saeed A, Ejaz SA, Attaullah HM, Channar SA, Qadir S, Abbas Q, Flörke U, Hökelek T.   +9 more
europepmc   +1 more source

Three-Component Synthesis of 1-Substituted 5-Aminotetrazoles Promoted by Bismuth Nitrate. [PDF]

J Org Chem
de Jesus IS, Trindade Gomes A, Sande I, Cunha S.   +3 more
europepmc   +1 more source