Results 81 to 90 of about 27,669 (247)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Relativistic Resonant Relations between Massive Black Hole Binary and Extreme Mass Ratio Inspiral

, 2012
One component of a massive black hole binary (MBHB) might capture a small third body, and then a hierarchical, inclined triple system would be formed. With the post-Newtonian approximation including radiation reaction, we analyzed the evolution of the ...
C. D. Murray, J. Binney, L. D. Landau, Naoki Seto, S. J. Peale   +4 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

SS Ari: a shallow-contact close binary system

, 2011
Two CCD epochs of light minimum and a complete R light curve of SS Ari are presented. The light curve obtained in 2007 was analyzed with the 2003 version of the W-D code.
A. Claret, A.F. Lanza, C. Hoffmeister, C.-H. Kim, C.-H. Kim, C.A. Tout, D. Kopal, D.H. Bradstreet, D.R. Faulkner, E.H. Kramer, F. Agerer, G. Russo, H. Huth, I.B. Biro, J. Hubscher, J. Hubscher, J. Hubscher, J. Hubscher, J. Kaluzny, J. Zhang, J.-J. He, J.H. Applegate, L. Liu, L. Liu, L.-J. Li, L.B. Lucy, O. Demircan, O.K. Odynskaya, P.G. Niarchos, P.P. Rainger, Q. Liu, R.E. Wilson, R.E. Wilson, R.E. Wilson, R.G. Samec, S.-B. Qian, S.-B. Qian, S.-B. Qian, S.-B. Qian, S.-B. Qian, S.-B. Qian, S.-B. Qian, S.-B. Qian, S.-B. Qian, S.C. Barden, S.M. Rucinski, T. Borkovits, T. Krajci, T. Pribulla, V. Keskin, W. Braune, W. Braune, W. Braune, W. Braune, W. Braune, W. Lu   +55 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Period changes in six semi-detached Algol-type binaries

, 2008
Six semi-detached Algol-type binaries lacking a period analysis were chosen to test for a presence of a third body. The O-C diagrams of these binaries were analyzed with the least-squares method by using all available times of minima.
A. Liakos, Albayrak, Applegate, Barblan, Borkovits, Brancewicz, Budding, Budding, Cannon, Ceraski, Chis, Cook, Faulkner, Frieboes-Conde, Guthnick, Halbedel, Hall, Harmanec, Hoffman, Hoffmeister, Hoffmeister, Irwin, Kaitchuck, Kaitchuck, Kaitchuk, Kharchenko, Kreiner, Kwee, Lanza, Lanza, M. Wolf, Mayer, P. Niarchos, P. Zasche, Qian, Romano, Rovithis-Livaniou, Soydugan, Svechnikov, Umana, Vesper, Woltjer, Yoon, Zavala   +43 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

First R and I Lights and Their Photometric Analyses of GSC 02393-00680

, 2011
We obtained complete $R$ and $I$ light curves of GSC 02393-00680 in 2008 and analyzed them with the 2003 version of the W-D code. It is shown that GSC 02393-00680 is a W-type shallow contact binary system with a high mass ratio $q=1.600$ and a degree of ...
Jia-Jia, He, Liang, Liu, Lin-Jia, Li, Sheng-Bang, Qian, Wen-Ping, Liao   +4 more
core   +1 more source