Results 81 to 90 of about 780,954 (268)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

Plasma proteins mediate the effects of the gut microbiota on the development of head and neck cancer: a two-sample and mediated Mendelian randomized study

Discover Oncology
Background Although previous observational studies have highlighted a possible association between the gut microbiota (GM) and head and neck cancer (HNC), the causal relationships remain unclear, particularly regarding the role of plasma proteins as ...
Jin-Hui Rao, Wen-Da Zhang, Cheng-Peng Zha, Min-Yue Zhang, Yu-Jie Xing, Zai-Hui Wang, Jun-Xian Yu, Dong-Yan He, Chuan-Zheng Sun, Lei Li   +9 more
doaj   +1 more source

The causal relationship between gut microbiota and tinnitus based on Mendelian randomization

Guangxi Yike Daxue xuebao
Objective To explore the causal relationship between gut microbiota and tinnitus based on Mendelian randomization (MR) research method. Methods Data on the gut microbiota in individuals from the genome wide association study (GWAS) (n=18, 340) using the ...
LIANG Yinfei, ZHOU Jingshi, ZHANG Shuqi, LI Lingwei, GU Jing, WEN Zhiyang, WU Dongxue, LI Zhicheng, ZENG Xiangli   +8 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

ALYREF-mediated RNA 5-methylcytosine modification promotes laryngeal cancer progression via stabilizing DDX11 mRNA

Scientific Reports
Laryngeal cancer (LC) is one of the malignant tumors affecting the head and neck region. 5-methylcytosine (m5C) is a common RNA modification that contributes to the carcinogenesis process.
Shanyan Bian, Rui Li, Yingwei Guo, Yingtao Wu, Jianqi Zhao, Zhiyuan Wang, Jiancong Huang   +6 more
doaj   +1 more source

Impact of smoking and alcohol drinking on the prognosis of 721 nasopharyngeal carcinoma

Brazilian Journal of Otorhinolaryngology
Objective: This study aimed to examine the correlation between smoking, alcohol drinking, and the prognosis of Nasopharyngeal Carcinoma (NPC). Methods: Clinical data from 721 NPC cases treated at our hospital between January 2005 and December 2010 were ...
Ling Tian, Min Zhao, Qing Yang, Xiaojiang Li, Yun Chen, Wu Xifang, Yan-Xin Ren   +6 more
doaj   +1 more source

Triple semicircular canal occlusion with endolymphatic sac decompression for intractable Meniere’s disease

Frontiers in Neurology
BackgroundMeniere’s disease (MD) is characterized by idiopathic endolymphatic hydrops (ELH). Frequent vertigo attacks is the most disabling symptom of MD.ObjectiveThis study evaluated the efficacy of triple semicircular canal occlusion combined with ...
Jiawang Tian, Gendi Yin, Qian Zhang, Shuqi Zhang, Xiangli Zeng, Yongqi Li   +5 more
doaj   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source