Results 51 to 60 of about 8,875,478 (340)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Uniformly boundedness of a class of non-linear differential equations of third order with multiple deviating arguments

Cubo, 2012
This paper deals with a certain third-order non-linear differential equation with multiple deviating arguments. Some sufficient conditions are set up for all solutions and their derivatives to be uniformly bounded.En este artículo se estudia un tipo de ...
Cemil Tunc, Hilmi Ergören
doaj  

Analýza sociálnej štruktúry stredovekej spoločnosti [PDF]

Historicka Sociologie, 2013
This study concentrates on the analysis of social structure of medieval society and accordingly on the acquisition of knowledge (1) about their orderliness, (2) inner processes (3) and least partially their influence on the process of formation of West ...
Margita Minichová
doaj  

Fučı́k Spectrum for a Third Order Equation

Journal of Differential Equations, 1996
The Fučík spectrum of the third order boundary value problem \[ y''' + \mu y^+ - \nu y^- = 0,\;y(0) = y'(0) = y(1) = 0 \tag{1} \] is investigated, i.e. the set of all \((\mu, \nu) \in \mathbb{R}^2\) where (1) has a nontrivial solution \(y\). The eigenvalues of (1) are the numbers \(\lambda\) for which \((\lambda, \lambda)\) belongs to the Fučík ...
GAUDENZI, Marcellino, PATRICH HABETS
openaire   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

The Implementation of Block Algorithm for the Solution of Third Order Oscillatory Problems

Cumhuriyet Science Journal
The implementation of block algorithm for the direct solution of third order oscillatory problems of the form has been studied in this paper. The methodology is carried out using the procedure of interpolation and collocation.
Taiye Oyedepo, Kareem Bello, Ajimoti Adam Ishaq, Adam Ajimoti Ishaq   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Oscillation Conditions for Third-Order Delay Differential Equations with Neutral-Type Term

Mathematics
In this work, we adopted an approach similar to that of Chatzarakis’, by transforming the oscillation analysis of third-order differential equations into an equivalent first-order problem.
Rongrong Guo, Haifeng Tian
doaj   +1 more source

Clouds of strings in third-order Lovelock gravity

, 2014
Lovelock theory is a natural extension of the Einstein theory of general relativity to higher dimensions in which the first and second orders correspond, respectively, to general relativity and Einstein-Gauss-Bonnet gravity.
Ghosh, Sushant G., Maharaj, Sunil D., Papnoi, Uma   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source