On a perturbed nonlinear third order differential equation [PDF]
summary:In this paper we will study some asymptotic properties of a nonlinear third order differential equation viewed as a perturbation of a simpler nonlinear equation investigated recently by the authors in [4]
Greguš, M.
core +1 more source
Third order differential equations with delay
In this paper, we study the oscillation and asymptotic properties of solutions of certain nonlinear third order differential equations with delay. In particular, we extend results of I.
Petr Liška
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Higher-order reverse automatic differentiation with emphasis on the third-order [PDF]
It is commonly assumed that calculating third order information is too expensive for most applications. But we show that the directional derivative of the Hessian ($D^3f(x)\cdot d$) can be calculated at a cost proportional to that of a state-of-the-art method for calculating the Hessian matrix.
Gower, R.M., Gower, A.L.
openaire +7 more sources
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Oscillation criteria for third-order functional differential equations with damping
This paper is a continuation of the recent study by Bohner et al [9] on oscillation properties of nonlinear third order functional differential equation under the assumption that the second order differential equation is nonoscillatory.
Martin Bohner +2 more
doaj
Oscillatory and asymptotically zero solutions of third order difference equations with quasidifferences [PDF]
In this paper, third order difference equations are considered. We study the nonlinear third order difference equation with quasidifferences. Using Riccati transformation techniques, we establish some sufficient conditions for each solution of this ...
Ewa Schmeidel
doaj
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source

