Results 191 to 200 of about 55,672 (327)

Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood‐brain barrier

open access: yesExploration, EarlyView.
The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood‐brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels.
Xiang Wang   +7 more
wiley   +1 more source

Retention in treatment and therapeutic adherence: How are these associated with therapeutic success? An analysis using real‐world data

open access: yesInternational Journal of Methods in Psychiatric Research, Volume 31, Issue 4, December 2022., 2022
Abstract Introduction Treatment retention and adherence are used as outcomes in numerous randomized clinical trials and observational studies conducted in the addiction field. Although usual criteria are 3/6 months of treatment retention or number of sessions attended, there is not a methodological support for conclusions using these criteria.
Daniel Dacosta‐Sánchez   +4 more
wiley   +1 more source

Care, and the less of it: Haunted gestures and the affective economy of pharmaceutical HIV prevention

open access: yesFeminist Anthropology, EarlyView.
Abstract Pre‐exposure prophylaxis (PrEP) is an antiretroviral drug that effectively prevents an HIV infection, which German statutory health insurance has covered since 2019. The drug's use in Germany has (re)surfaced ambivalent emotions: hopes for an HIV/AIDS‐free future and sexual liberation rub against enduring worries and moralizations of ...
Max Schnepf
wiley   +1 more source

Polyuria in patients with lower urinary tract symptoms: Prevalence and etiology

open access: yesNeurourology and Urodynamics, Volume 42, Issue 1, Page 256-262, January 2023., 2023
Abstract Introduction Patients with lower urinary tract symptoms (LUTS) can be subcategorized into polyuria, normal or oliguria groups. Polyuria may be caused by pathologies including diabetes mellitus (DM), chronic kidney disease (CKD), diabetes insipidus (DI), or primary polydipsia (PPD).
George Z. Fisch   +8 more
wiley   +1 more source

Prophylactic Effects of Astragalus Polysaccharides on Depression‐Like Behaviors in Rats With Chronic Unpredictable Mild Stress: A Role of Gut‐Microbiota–Brain Axis

open access: yesFood Frontiers, EarlyView.
This study complements the pathogenesis of depression, and the effects of APS from the perspective of “gut microbiome ‐ immunity ‐ metabolome” axis. This study also provides a novel research strategy and approaches for demonstrating the anti‐depression effects of plant polysaccharides, and lays a solid foundation for discovering new medicines from ...
Xiaojie Liu   +9 more
wiley   +1 more source

Pilot study on the impact of a carbohydrate loading drink on postprandial glycemic responses and gastric emptying in adults with prediabetes and type 2 diabetes mellitus

open access: yesNutrition in Clinical Practice, Volume 38, Issue 1, Page 108-117, February 2023., 2023
Abstract Background Preoperative carbohydrate (CHO) loading improves patient outcomes but is not extensively studied in individuals with diabetes mellitus (DM), resulting in limited professional recommendations. This study examined postprandial glycemic responses and gastric emptying rates following consumption of a CHO drink in adults with and without
Bridget A. Cassady   +4 more
wiley   +1 more source

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