Results 31 to 40 of about 763 (127)

Establishment of a Replicon Reporter of the Emerging Tick-Borne Bourbon Virus and Use It for Evaluation of Antivirals

open access: yesFrontiers in Microbiology, 2020
Bourbon virus (BRBV) was first isolated from a patient hospitalized at the University of Kansas Hospital in 2014. Since then, several deaths have been reported to be caused by BRBV infection in the Midwest and Southern United States. BRBV is a tick-borne
Siyuan Hao   +7 more
doaj   +1 more source

Characterisation of putative novel tick viruses and zoonotic risk prediction. [PDF]

open access: yesEcol Evol
Tick‐borne viruses remain a substantial zoonotic risk worldwide, so knowledge of the diversity of tick viruses has potential health consequences. Through data mining and bioinformatic analyses of more than 37,800 public meta‐genomic and ‐transcriptomic data sets, we found five putative novel Alphatetra‐like viruses, four putative novel Orthomyxo‐like ...
Lin Y, Pascall DJ.
europepmc   +2 more sources

Molecular Evidence of Orthomyxovirus Presence in Colombian Neotropical Bats

open access: yesFrontiers in Microbiology, 2022
The Orthomyxoviridae family includes the genera Influenzavirus, Isavirus, Quaranjavirus, and Thogotovirus. In turn, Influenzavirus can be classified into four types: α, β, γ, and δ (Formerly A, B, C, and D), from which Alphainfluenzavirus (AIV) has the ...
Manuel Uribe   +3 more
doaj   +1 more source

Pathogen Spillover to an Invasive Tick Species: First Detection of Bourbon Virus in Haemaphysalis longicornis in the United States

open access: yesPathogens, 2022
Haemaphysalis longicornis (Neumann, 1901) (Acari: Ixodidae), the Asian longhorned tick, is an invasive tick species present in the USA since at least 2017 and has been detected in one-third of Virginia counties.
Alexandra N. Cumbie   +2 more
doaj   +1 more source

Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains. [PDF]

open access: yesPLoS ONE, 2014
Orthomyxovirus Influenza A virus (IAV) heterotrimeric polymerase performs transcription of viral mRNAs by cap-snatching, which involves generation of capped primers by host pre-mRNA binding via the PB2 subunit cap-binding site and cleavage 10-13 ...
Delphine Guilligay   +7 more
doaj   +1 more source

The Study of Viral RNA Diversity in Bird Samples Using De Novo Designed Multiplex Genus‐Specific Primer Panels

open access: yesAdvances in Virology, Volume 2018, Issue 1, 2018., 2018
Advances in the next generation sequencing (NGS) technologies have significantly increased our ability to detect new viral pathogens and systematically determine the spectrum of viruses prevalent in various biological samples. In addition, this approach has also helped in establishing the associations of viromes with many diseases.
Andrey A. Ayginin   +10 more
wiley   +1 more source

Vector‐borne diseases

open access: yesEFSA Journal, Volume 15, Issue 5, May 2017., 2017
Abstract After a request from the European Commission, EFSA's Panel on Animal Health and Welfare summarised the main characteristics of 36 vector‐borne diseases (VBDs) in 36 Disease Profiles. The risk of introduction in the EU through movement of livestock or pets was assessed for each of the 36 VBDs individually, using a semiquantitative Method to ...
EFSA Panel on Animal Health and Welfare   +36 more
wiley   +1 more source

Structural analysis of tumor‐related single amino acid mutations in human MxA protein

open access: yesCancer Communications, Volume 34, Issue 3, Page 1-11, December 2015., 2015
Abstract Background Human myxovirus resistant protein A (MxA), encoded by the myxovirus resistance 1 (Mx1) gene, is an interferon (IFN)‐triggered dynamin‐like multi‐domain GTPase involved in innate immune responses against viral infections. Recent studies suggest that MxA is associated with several human cancers and may be a tumor suppressor and a ...
Jia‐Li Hu   +4 more
wiley   +1 more source

Rapid Molecular Detection Methods for Arboviruses of Livestock of Importance to Northern Europe

open access: yesBioMed Research International, Volume 2012, Issue 1, 2012., 2012
Arthropod‐borne viruses (arboviruses) have been responsible for some of the most explosive epidemics of emerging infectious diseases over the past decade. Their impact on both human and livestock populations has been dramatic. The early detection either through surveillance or diagnosis of virus will be a critical feature in responding and resolving ...
Nicholas Johnson   +5 more
wiley   +1 more source

Soluble Host Defense Lectins in Innate Immunity to Influenza Virus

open access: yesBioMed Research International, Volume 2012, Issue 1, 2012., 2012
Host defenses against viral infections depend on a complex interplay of innate (nonspecific) and adaptive (specific) components. In the early stages of infection, innate mechanisms represent the main line of host defense, acting to limit the spread of virus in host tissues prior to the induction of the adaptive immune response.
Wy Ching Ng   +4 more
wiley   +1 more source

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