Results 21 to 30 of about 666 (103)

Establishment of a Replicon Reporter of the Emerging Tick-Borne Bourbon Virus and Use It for Evaluation of Antivirals

Frontiers in Microbiology, 2020
Bourbon virus (BRBV) was first isolated from a patient hospitalized at the University of Kansas Hospital in 2014. Since then, several deaths have been reported to be caused by BRBV infection in the Midwest and Southern United States. BRBV is a tick-borne
Siyuan Hao, Kang Ning, Xiaomei Wang, Jianke Wang, Fang Cheng, Safder S. Ganaie, John E. Tavis, Jianming Qiu   +7 more
doaj   +1 more source

Experimental Infection of Amblyomma americanum (Acari: Ixodidae) With Bourbon Virus (Orthomyxoviridae: Thogotovirus) [PDF]

Journal of Medical Entomology, 2020
Abstract Following the recent discovery of Bourbon virus (BRBV) as a human pathogen, and the isolation of the virus from Amblyomma americanum (L.) collected near the location of a fatal human case, we undertook a series of experiments to assess the laboratory vector competence of this tick species for BRBV.
Marvin S, Godsey, Dominic, Rose, Kristin L, Burkhalter, Nicole, Breuner, Angela M, Bosco-Lauth, Olga I, Kosoy, Harry M, Savage   +6 more
openaire   +2 more sources

Structures of human-infecting Thogotovirus fusogens support a common ancestor with insect baculovirus [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Thogotoviruses belong to Orthomyxoviridae family and infect a variety of mammalian hosts, including humans. The emergence of these viruses poses great threats to public health and the economy.
Ruchao Peng, Shuijun Zhang, Yingzi Cui, Yi Shi, George F. Gao, Jianxun Qi   +5 more
openaire   +2 more sources

Molecular Evidence of Orthomyxovirus Presence in Colombian Neotropical Bats

Frontiers in Microbiology, 2022
The Orthomyxoviridae family includes the genera Influenzavirus, Isavirus, Quaranjavirus, and Thogotovirus. In turn, Influenzavirus can be classified into four types: α, β, γ, and δ (Formerly A, B, C, and D), from which Alphainfluenzavirus (AIV) has the ...
Manuel Uribe, Manuel Uribe, Miguel E. Rodríguez-Posada, Gloria C. Ramirez-Nieto   +3 more
doaj   +1 more source

Pathogen Spillover to an Invasive Tick Species: First Detection of Bourbon Virus in Haemaphysalis longicornis in the United States

Pathogens, 2022
Haemaphysalis longicornis (Neumann, 1901) (Acari: Ixodidae), the Asian longhorned tick, is an invasive tick species present in the USA since at least 2017 and has been detected in one-third of Virginia counties.
Alexandra N. Cumbie, Rebecca N. Trimble, Gillian Eastwood   +2 more
doaj   +1 more source

Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains. [PDF]

PLoS ONE, 2014
Orthomyxovirus Influenza A virus (IAV) heterotrimeric polymerase performs transcription of viral mRNAs by cap-snatching, which involves generation of capped primers by host pre-mRNA binding via the PB2 subunit cap-binding site and cleavage 10-13 ...
Delphine Guilligay, Jan Kadlec, Thibaut Crépin, Thomas Lunardi, Denis Bouvier, Georg Kochs, Rob W H Ruigrok, Stephen Cusack   +7 more
doaj   +1 more source

The Study of Viral RNA Diversity in Bird Samples Using De Novo Designed Multiplex Genus‐Specific Primer Panels

Advances in Virology, Volume 2018, Issue 1, 2018., 2018
Advances in the next generation sequencing (NGS) technologies have significantly increased our ability to detect new viral pathogens and systematically determine the spectrum of viruses prevalent in various biological samples. In addition, this approach has also helped in establishing the associations of viromes with many diseases.
Andrey A. Ayginin, Ekaterina V. Pimkina, Alina D. Matsvay, Anna S. Speranskaya, Marina V. Safonova, Ekaterina A. Blinova, Ilya V. Artyushin, Vladimir G. Dedkov, German A. Shipulin, Kamil Khafizov, Gary S. Hayward   +10 more
wiley   +1 more source

Vector‐borne diseases

EFSA Journal, Volume 15, Issue 5, May 2017., 2017
Abstract After a request from the European Commission, EFSA's Panel on Animal Health and Welfare summarised the main characteristics of 36 vector‐borne diseases (VBDs) in 36 Disease Profiles. The risk of introduction in the EU through movement of livestock or pets was assessed for each of the 36 VBDs individually, using a semiquantitative Method to ...
EFSA Panel on Animal Health and Welfare, Simon More, Dominique Bicout, Anette Bøtner, Andrew Butterworth, Paolo Calistri, Aline De Koeijer, Klaus Depner, Sandra Edwards, Bruno Garin‐Bastuji, Margaret Good, Christian Gortazar Schmidt, Virginie Michel, Miguel Angel Miranda, Søren Saxmose Nielsen, Mohan Raj, Liisa Sihvonen, Hans Spoolder, Hans‐Hermann Thulke, Antonio Velarde, Preben Willeberg, Christoph Winckler, Andrea Bau, Beatriz Beltran‐Beck, Edoardo Carnesecchi, Pascal Casier, Ewelina Czwienczek, Sofie Dhollander, Marios Georgiadis, Andrey Gogin, Luca Pasinato, Jane Richardson, Francesca Riolo, Gianluca Rossi, Matthew Watts, Eliana Lima, Jan Arend Stegeman   +36 more
wiley   +1 more source

Ixodid ticks and tick-borne infections in the Republic of Cuba - literature review and rationale for risk assessment

Acta Biomedica Scientifica, 2018
The Republic of Cuba is a popular destination for Russian tourists and about 30-50 thousands of Russian citizens visit Cuba annually. However, the recreational activity is often associated with the risk of Ixodid ticks bites and infection with tick-borne
M. A. Khasnatinov, L. V. Rychkova, G. I. Rodriguez, G. B. Corona, G. A. Danchinova   +4 more
doaj   +1 more source

Structural analysis of tumor‐related single amino acid mutations in human MxA protein

Cancer Communications, Volume 34, Issue 3, Page 1-11, December 2015., 2015
Abstract Background Human myxovirus resistant protein A (MxA), encoded by the myxovirus resistance 1 (Mx1) gene, is an interferon (IFN)‐triggered dynamin‐like multi‐domain GTPase involved in innate immune responses against viral infections. Recent studies suggest that MxA is associated with several human cancers and may be a tumor suppressor and a ...
Jia‐Li Hu, Yi‐Jun Hua, Yang Chen, Bing Yu, Song Gao   +4 more
wiley   +1 more source