Results 141 to 150 of about 66,978 (239)

Targeting hexokinase 2 to induce breast cancer cell senescence

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof   +8 more
wiley   +1 more source

Education Research: Feasibility and Impact of Academic Half-Day at a Large Academic Neurology Residency Program. [PDF]

open access: yesNeurol Educ
Greenberg JH   +10 more
europepmc   +1 more source

Patient‐Derived IgG Epitope Mapping of Bet v 1 Reveals Hypoallergenic Peptide Candidates for Safe and Next‐Generation Allergen Immunotherapy

open access: yesClinical &Experimental Allergy, EarlyView.
Mapping IgG epitopes of the major birch allergen Bet v 1 identified patient‐derived, hypoallergenic peptides that did not trigger degranulation. These findings support a novel, safer approach for peptide‐based allergen immunotherapy that leverages naturally induced IgG specificities from allergic individuals. ABSTRACT Background Allergen immunotherapy (
Lara Šošić   +10 more
wiley   +1 more source

Pre-analytical barriers to blood culture completion in a large laboratory network. [PDF]

open access: yesJ Med Microbiol
Inglis TJJ   +4 more
europepmc   +1 more source

Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non‐Functioning Pituitary Adenoma

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective The effect of transsphenoidal surgery (TSS) on the hypothalamic‐pituitary‐gonadal (HPG) axis in patients with non‐functioning pituitary adenomas (NFPA) is underexplored, especially in women. Our aim was to investigate the HPG axis function before and after TSS, its association with quality of life (QoL), and to identify factors that ...
Victor Hantelius   +6 more
wiley   +1 more source

GPND-AI NULISA: A 15-Protein AI classifier for diagnosis and co-pathology profiling across neurodegenerative diseases. [PDF]

open access: yesAlzheimers Dement
Xu Y   +25 more
europepmc   +1 more source

Evaluating synthetic substitutes to reduce illegal harvesting and support species recovery

open access: yesConservation Biology, EarlyView.
Abstract Providing synthetic substitutes is a widely promoted strategy to shift consumer demand away from wildlife products derived from threatened species. Yet, there is little evidence on whether product substitution prevents illegal or unsustainable harvesting and contributes to the recovery of threatened populations.
Aditya Shekhar Malgaonkar   +17 more
wiley   +1 more source

Metabarcoding of Pollen Carried by Syrphids Reveals Novel Plant–Pollinator Interactions in a Protected Natural Area and Agricultural Sites

open access: yesEntomologia Experimentalis et Applicata, EarlyView.
Using DNA metabarcoding, this study investigates pollen transported by syrphids (Syrphidae) in the Dolomiti Bellunesi National Park and agricultural sites in Northern Italy. The analysis reveals a high diversity of visited plant taxa, including previously undocumented plant–pollinator interactions.
Serena Magagnoli   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy