Results 151 to 160 of about 67,963 (258)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Clinical correlation of anti-desmoglein antibody dynamics in pemphigus treated with rituximab. [PDF]

Front Immunol
Naidu V, Jain HA, Yalcinkaya A, Charavanamuttu Y, Biswas D, Ali N, Mee JB, Chauhan J, Semkova K, Benton EC, Karagiannis SN, Setterfield J, Groves RW, Tull TJ.   +13 more
europepmc   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Erythrocyte Fragility in Progressive Multiple Sclerosis. [PDF]

Eur J Neurol
Jacob C, Williams TE, Stuart CM, Witkover A, Hametner S, Lassmann H, Bangham CRM, Chataway J, Galea I.   +8 more
europepmc   +1 more source

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder, Anna‐Maria Pfützenreuter, Lea Maria Funke, Maria Johanna Baier, Daniel Tarnowski, Laura Stengel, Lars Siegfried Maier, Can Martin Sag   +7 more
wiley   +1 more source

Prospective randomized control trial measuring posterior capsular opacification rates and visual outcomes following insertion of two monofocal intraocular lenses: the hydrophobic RayOne 800C and the hydrophilic RayOne 600C: 12-month results. [PDF]

J Cataract Refract Surg
Naderi K, Naderi K, Jameel A, Lam CFJ, Low S, Wagh V, Bhogal M, Ritchie A, Robbie S, Hammond C, Mohamed M, Stanojcic N, Azan E, Mann S, Hull C, O'Brart D.   +15 more
europepmc   +1 more source

Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non‐Functioning Pituitary Adenoma

Clinical Endocrinology, EarlyView.
ABSTRACT Objective The effect of transsphenoidal surgery (TSS) on the hypothalamic‐pituitary‐gonadal (HPG) axis in patients with non‐functioning pituitary adenomas (NFPA) is underexplored, especially in women. Our aim was to investigate the HPG axis function before and after TSS, its association with quality of life (QoL), and to identify factors that ...
Victor Hantelius, Gudmundur Johannsson, Sofie Jakobsson, Erik Thurin, Tobias Hallen, Thomas Skoglund, Oskar Ragnarsson   +6 more
wiley   +1 more source

Development of a Machine Learning-Based Predictive Model for Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma. [PDF]

Cancer Med
Li T, Butler TO, Hu Y, Li S.
europepmc   +1 more source

Leveraging urban greenspaces to bolster regional conservation priorities

Conservation Science and Practice, EarlyView.
This article demonstrates that urban greenspaces currently excluded from the San Francisco Bay Area's regional conservation plan offer significant, measurable conservation value. We found these overlooked areas host vital biodiversity and critically improve habitat connectivity, highlighting that incorporating urban greenspaces will be key in meeting ...
Cesar O. Estien, Avery P. Hill, Tom Robinson, Rebecca F. Johnson, Christopher J. Schell, Christine E. Wilkinson   +5 more
wiley   +1 more source

Assessment of Early Antibiotic Administration for Patients With Sepsis in the Emergency Department: A Retrospective Observational Study at a Tertiary Care Hospital. [PDF]

Cureus
Thomas A, E P S, Unnikrishnan VC, Sajan R, Vincent V A, Trikkur S, Kumar G, Nair S, Prasad S B, Mohan N.   +9 more
europepmc   +1 more source