Results 101 to 110 of about 3,196,328 (354)
Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis
Advanced Science, EarlyView.Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong +17 morewiley +1 more sourceCritical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis
Advanced Science, EarlyView.The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang +13 morewiley +1 more source2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS).
European Heart Journal, 2020 G. Hindricks, Tatjana Potpara, Nikolaos Dagres, Elena Arbelo, Jeroen J. Bax, Carina Blomström-Lundqvist, G. Boriani, Manuel Castellá, G. Dan, Polychronis Dilaveris, Laurent Fauchier, Gerasimos S Filippatos, Jonathan M Kalman, M. la Meir, Deirdre A. Lane, Jean-Pierre Lebeau, M. Lettino, G. Lip, Fausto J. Pinto, G. Thomas, M. Valgimigli, I. V. Van Gelder, Bart Van Putte, Caroline L Watkins, Paulus Kirchhof, Michael Kühne, V. Aboyans, Anders Ahlsson, P. Balsam, Johann Bauersachs, Stefano Benussi, Axel Brandes, Frieder Braunschweig, A. Camm, Davide Capodanno, Barbara Casadei, D. Conen, H. Crijns, Victoria Delgado, Dobromir Dobrev, Heinz Drexel, Lars Eckardt, Donna Fitzsimons, Thierry Folliguet, Chris Gale, B. Gorenek, K. Haeusler, Hein Heidbuchel, Bernard Iung, Hugo A. Katus, D. Kotecha, Ulf Landmesser, Christophe Leclercq, Basil S. Lewis, J. Mascherbauer, J. L. Merino, Béla Merkely, Lluís Mont, Christian Mueller, K. V. Nagy, Jonas Oldgren, Nikola Pavlović, Roberto F E Pedretti, Steffen Petersen, J. Piccini, B. A. Popescu, H. Pürerfellner, Dimitrios J. Richter, M. Roffi, A. Rubboli, D. Scherr, Renate B. Schnabel, Iain A Simpson, E. Shlyakhto, Moritz F. Sinner, J. Steffel, M. Sousa‐Uva, P. Suwalski, M. Svetlosak, R. Touyz, Stephan Windecker, Colin Baigent, Jean-Philippe Collet, V. Dean, D. Grobbee, Sigrun Halvorsen, P. Jüni, A. Sonia Petronio, T. Delassi, H. Sisakian, Alexandr Chasnoits, M. De Pauw, Elnur Smajić, T. Shalganov, P. Avraamides, Josef Kautzner, Christian Gerdes, Ahmad Abd Alaziz, P. Kampus, P. Raatikainen, S. Bovéda, G. Papiashvili, Vassilios Vassilikos, Zoltán Csanádi, D. Arnar, Joseph Galvin, A. Barsheshet, P. Caldarola, A. Rakisheva, I. Bytyçi, Alina Kerimkulova, O. Kalējs, Mario Njeim, A. Puodziukynas, L. Groben, M. A. Sammut, A. Grosu, A. Bošković, A. Moustaghfir, N. D. de Groot, Lidija Poposka, O. Anfinsen, Przemysław Mitkowski, Diogo Cavaco, C. Silişte, Evgeny N Mikhaylov, Luca Bertelli, Dejan Kojic, Róbert Hatala, Zlatko Fras, Fernando Arribas, T. Juhlin, C. Sticherling, Leila Abid, I. Atar, O. Sychov, Matthew G D Bates, Nodir U Zakirov +137 moresemanticscholar +1 more sourceEnhanced recovery pathways in thoracic surgery from Italian VATS Group: perioperative analgesia protocols.
Journal of Thoracic Disease, 2018 Video-assisted thoracoscopic surgery (VATS) is a minimally invasive technique that allows a faster recovery after thoracic surgery. Although enhanced recovery after surgery (ERAS) principles seem reasonably applicable to thoracic surgery, there is little F. Piccioni, M. Segat, S. Falini, Marzia Umari, O. Putina, Lucio Cavaliere, R. Ragazzi, D. Massullo, M. Taurchini, C. Del Naja, A. Droghetti +10 moresemanticscholar +1 more sourceComprehensive Insights into Tracheoesophageal Fistula Pathophysiology, Diagnosis, Treatment, and Future Directions
Advanced Science, EarlyView.Tracheoesophageal fistula (TEF), a pathological trachea‐esophagus connection, arises congenitally or from malignancy/radiotherapy/trauma, causing aspiration and malnutrition. Diagnosis utilizes imaging and endoscopy. Treatment ranges from endoscopic stenting to surgical repair and conservative management.Gang Li, Zhe Wang, Jia Liu, Shenbo Fu, Longmei Xue, Zijun Liao, Rong Yang, Shanping Huang, Rui Xu, Peng Chen, Yong Chen +10 morewiley +1 more sourceA Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues
Advanced Science, EarlyView.Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...Liang Shan, Xin Xu, Lin Huang, Dan Li, Yiran Deng, Xiangfei Xue, Susu Guo, Yiman Huang, Xiao Zhang, Yongchun Yu, Lifang Ma, Kun Qian, Jiayi Wang +12 morewiley +1 more source
