Results 121 to 130 of about 3,114,604 (362)

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science, EarlyView.
Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
wiley   +1 more source

Exclusive right thoracic approach for esophagus surgery [PDF]

, 2017
Chuan Li, Nan Ge, Yi Shen, Wenjie Jiao
openalex   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

2021 The American Association for Thoracic Surgery expert consensus document: Surgical treatment of acute type A aortic dissection.

Journal of Thoracic and Cardiovascular Surgery, 2021
S. Malaisrie, W. Szeto, M. Halas, L. Girardi, J. Coselli, T. Sundt, E. Chen, M. Fischbein, T. Gleason, Y. Okita, M. Ouzounian, H. Patel, E. Roselli, M. Shrestha, L. Svensson, M. Moon   +15 more
semanticscholar   +1 more source

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source

Complex Presentation of Anterior Chest Wall Chondrosarcoma

Clinical and Biomedical Research, 2021
Chondrosarcoma is the third most common primary bone malignancy, but its thoracic presentation is unusual compared to the pelvis and extremities. Chest wall chondrosarcomas are difficult to be surgically resected due to their proximity to neurovascular ...
Augusto Mädke Brenner, Marcio Luis Lucas, Eduardo Abeche Generosi, Gabriel Ribeiro Mädke   +3 more
doaj  

Piezo1 Upregulation in Monocyte‐Derived Macrophages Impairs Post‐Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis

Advanced Science, EarlyView.
This study reports early Piezo1 activation in bone marrow monocyte‐derived macrophages (MoMs) during myocardial infarction (MI), which governs the fate and function of recruited macrophages. The recruited MoMs with increased Piezo1 expression exhibit increased ferroptosis and defective efferocytosis, delayed clearance of dead cells and resolution of ...
Lu Peng, Yunlong Xia, Huishou Zhao, Yongzhen Guo, Xiaoming Xu, Xue Han, Shiyue Wang, Fengyue Ding, Quanchi Liu, Congye Li, Yuan He, Zhaoyi Luo, Qiaojuan Wang, Xing Zhang, Feng Gao, Yajing Wang, Yulin Li, Shengpeng Wang, Ling Tao, Wenjun Yan   +19 more
wiley   +1 more source

COPD Severity as an Independent Predictor of Long-Term Survival in Operable Lung Cancer: A Retrospective Analysis from a High-Volume Thoracic Surgery Center

International Journal of COPD
Julia Zimmermann,1 Johannes Schön,1 Valentina Pfeiffer,1 Tim-Mathis Beutel,1 Annalena Felker,1 Elvira Stacher-Priehse,2 Fuad Damirov,1 Niels Reinmuth,3 Rudolf A Hatz,1,4 Christian P Schneider,1,4 Mircea Gabriel Stoleriu1,4 1Department of Thoracic Surgery,
Zimmermann J, Schön J, Pfeiffer V, Beutel TM, Felker A, Stacher-Priehse E, Damirov F, Reinmuth N, Hatz RA, Schneider CP, Stoleriu MG   +10 more
doaj  

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

Trends in isolated coronary artery bypass grafting: An analysis of the Society of Thoracic Surgeons adult cardiac surgery database [PDF]

, 2012
Andrew W. ElBardissi, Sary F. Aranki, Shubin Sheng, Sean M. O’Brien, Caprice C. Greenberg, James S. Gammie   +5 more
openalex   +1 more source