Results 11 to 20 of about 160,099 (251)

Regional extracellular volume within late gadolinium enhancement-positive myocardium to differentiate cardiac sarcoidosis from myocarditis of other etiology: a cardiovascular magnetic resonance study

Journal of Cardiovascular Magnetic Resonance, 2023
Background Cardiovascular magnetic resonance (CMR) plays a pivotal role in diagnosing myocardial inflammation. In addition to late gadolinium enhancement (LGE), native T1 and T2 mapping as well as extracellular volume (ECV) are essential tools for tissue
Julia Treiber, Dijana Novak, Ulrich Fischer-Rasokat, Jan Sebastian Wolter, Steffen Kriechbaum, Maren Weferling, Beatrice von Jeinsen, Andreas Hain, Andreas J. Rieth, Tamo Siemons, Till Keller, Christian W. Hamm, Andreas Rolf   +12 more
doaj   +1 more source

Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp

Scientific Reports, 2021
The patch-clamp technique and more recently the high throughput patch-clamp technique have contributed to major advances in the characterization of ion channels.
Jérôme Montnach, Maxime Lorenzini, Adrien Lesage, Isabelle Simon, Sébastien Nicolas, Eléonore Moreau, Céline Marionneau, Isabelle Baró, Michel De Waard, Gildas Loussouarn   +9 more
doaj   +1 more source

Cardiac biomarkers as indicators of right ventricular dysfunction and recovery in chronic thromboembolic pulmonary hypertension patients after balloon pulmonary angioplasty therapy – a cardiac magnetic resonance imaging cohort study

Pulmonary Circulation, 2021
Background In chronic thromboembolic pulmonary hypertension, right heart failure determines outcome. Balloon pulmonary angioplasty therapy allows right heart recovery, which can be monitored by cardiac magnetic resonance imaging.
Steffen D. Kriechbaum, Julia M. Vietheer, Christoph B. Wiedenroth, Felix Rudolph, Marta Barde, Jan‐Sebastian Wolter, Moritz Haas, Ulrich Fischer‐Rasokat, Maren Weferling, Andreas Rolf, Christian W. Hamm, Eckhard Mayer, Stefan Guth, Till Keller, Fritz C. Roller, Christoph Liebetrau   +15 more
doaj   +1 more source

Mouse models of SCN5A-related cardiac arrhythmias

Frontiers in Physiology, 2012
Mutations of SCN5A gene, which encodes the α-subunit of the voltage-gated Na+ channel NaV1.5, underlie hereditary cardiac arrhythmic syndromes such as the type 3 long QT syndrome, cardiac conduction diseases, the Brugada syndrome, the sick sinus syndrome,
Flavien eCharpentier, Flavien eCharpentier, Flavien eCharpentier, Mickael eDerangeon, Mickael eDerangeon, Mickael eDerangeon, Jérôme eMontnach, Jérôme eMontnach, Jérôme eMontnach, Isabelle eBaró, Isabelle eBaró, Isabelle eBaró   +11 more
doaj   +1 more source

Outpatient Community-Acquired Pneumonia: Out of Sight, Away from Prevention

Acta Médica Portuguesa, 2021
N/a.
Mónica Pereira, António Diniz, Filipe Froes   +2 more
doaj   +1 more source

Definition of acute kidney injury impacts prevalence and prognosis in ACS patients undergoing coronary angiography

BMC Cardiovascular Disorders, 2021
Background Development of acute kidney injury (AKI) in invasively managed patients with acute coronary syndrome (ACS) is associated with a markedly increased mortality risk.
Maren Weferling, Christoph Liebetrau, Daniel Kraus, Philipp Zierentz, Beatrice von Jeinsen, Oliver Dörr, Michael Weber, Holger Nef, Christian W. Hamm, Till Keller   +9 more
doaj   +1 more source

Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism

Scientific Reports, 2020
Prokaryotic NaV channels are tetramers and eukaryotic NaV channels consist of a single subunit containing four domains. Each monomer/domain contains six transmembrane segments (S1-S6), S1-S4 being the voltage-sensor domain and S5-S6 the pore domain.
Olfat A. Malak, Fayal Abderemane-Ali, Yue Wei, Fabien C. Coyan, Gilyane Pontus, David Shaya, Céline Marionneau, Gildas Loussouarn   +7 more
doaj   +1 more source

FACS-assisted CRISPR-Cas9 genome editing of human induced pluripotent stem cells

STAR Protocols, 2022
Summary: This manuscript proposes an efficient and reproducible protocol for the generation of genetically modified human induced pluripotent stem cells (hiPSCs) by genome editing using CRISPR-Cas9 technology.
Amandine Caillaud, Antoine Lévêque, Aurélie Thédrez, Aurore Girardeau, Robin Canac, Lise Bray, Manon Baudic, Julien Barc, Nathalie Gaborit, Guillaume Lamirault, Betty Gardie, Salam Idriss, Antoine Rimbert, Cédric Le May, Bertrand Cariou, Karim Si-Tayeb   +15 more
doaj   +1 more source

Dysfunction of the Voltage‐Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe Brugada syndrome is an inherited cardiac arrhythmia associated with high risk of sudden death. Although 20% of patients with Brugada syndrome carry mutations in SCN5A, the molecular mechanisms underlying this condition are still largely ...
Vincent Portero, Solena Le Scouarnec, Zeineb Es‐Salah‐Lamoureux, Sophie Burel, Jean‐Baptiste Gourraud, Stéphanie Bonnaud, Pierre Lindenbaum, Floriane Simonet, Jade Violleau, Estelle Baron, Eléonore Moreau, Carol Scott, Stéphanie Chatel, Gildas Loussouarn, Thomas O'Hara, Philippe Mabo, Christian Dina, Hervé Le Marec, Jean‐Jacques Schott, Vincent Probst, Isabelle Baró, Céline Marionneau, Flavien Charpentier, Richard Redon   +23 more
doaj   +1 more source

Feasibility of setting up a pre-operative optimisation ‘pre-hab’ service for lung cancer surgery in the UK

Perioperative Medicine, 2020
Pre-operative optimisation ‘pre-hab’ is a growing area in peri-operative medicine. This is usually undertaken with the aim of reducing post-operative complications.
William M. Ricketts, Karen Bollard, Emma Streets, Kristi Hutton, Catherine Hornby, Kelvin Lau   +5 more
doaj   +1 more source