Results 21 to 30 of about 450,295 (383)

Dysfunction of the Voltage‐Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe Brugada syndrome is an inherited cardiac arrhythmia associated with high risk of sudden death. Although 20% of patients with Brugada syndrome carry mutations in SCN5A, the molecular mechanisms underlying this condition are still largely ...
Vincent Portero, Solena Le Scouarnec, Zeineb Es‐Salah‐Lamoureux, Sophie Burel, Jean‐Baptiste Gourraud, Stéphanie Bonnaud, Pierre Lindenbaum, Floriane Simonet, Jade Violleau, Estelle Baron, Eléonore Moreau, Carol Scott, Stéphanie Chatel, Gildas Loussouarn, Thomas O'Hara, Philippe Mabo, Christian Dina, Hervé Le Marec, Jean‐Jacques Schott, Vincent Probst, Isabelle Baró, Céline Marionneau, Flavien Charpentier, Richard Redon   +23 more
doaj   +1 more source

Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism

Scientific Reports, 2020
Prokaryotic NaV channels are tetramers and eukaryotic NaV channels consist of a single subunit containing four domains. Each monomer/domain contains six transmembrane segments (S1-S6), S1-S4 being the voltage-sensor domain and S5-S6 the pore domain.
Olfat A. Malak, Fayal Abderemane-Ali, Yue Wei, Fabien C. Coyan, Gilyane Pontus, David Shaya, Céline Marionneau, Gildas Loussouarn   +7 more
doaj   +1 more source

Definition of acute kidney injury impacts prevalence and prognosis in ACS patients undergoing coronary angiography

BMC Cardiovascular Disorders, 2021
Background Development of acute kidney injury (AKI) in invasively managed patients with acute coronary syndrome (ACS) is associated with a markedly increased mortality risk.
Maren Weferling, Christoph Liebetrau, Daniel Kraus, Philipp Zierentz, Beatrice von Jeinsen, Oliver Dörr, Michael Weber, Holger Nef, Christian W. Hamm, Till Keller   +9 more
doaj   +1 more source

Outpatient Community-Acquired Pneumonia: Out of Sight, Away from Prevention

Acta Médica Portuguesa, 2021
N/a.
Mónica Pereira, António Diniz, Filipe Froes   +2 more
doaj   +1 more source

Measuring the frequency response of the honeybee thorax

Bioinspiration & Biomimetics, 2020
Insects with asynchronous flight muscles are believed to flap at the effective fundamental frequency of their thorax–wing system. Flapping in this manner leverages the natural elasticity of the thorax to reduce the energetic requirements of flight ...
Mark A. Jankauski
semanticscholar   +1 more source

A quality improvement program to reduce the time on the lung transplant waiting list at the Nantes University Hospital

Orphanet Journal of Rare Diseases, 2018
Background In 2010, the time on the lung transplant waiting list in Nantes University Hospital (NUH) was 9.2 months, compared to a French national median of about 4 months.
Isabelle Danner-Boucher, Véronique Loppinet, Aurore Boxus, Claire Dary, Anne Brigitte Lambert, Marine Prieur, Céline Vallet, Adrien Tissot   +7 more
doaj   +1 more source

Feasibility of setting up a pre-operative optimisation ‘pre-hab’ service for lung cancer surgery in the UK

Perioperative Medicine, 2020
Pre-operative optimisation ‘pre-hab’ is a growing area in peri-operative medicine. This is usually undertaken with the aim of reducing post-operative complications.
William M. Ricketts, Karen Bollard, Emma Streets, Kristi Hutton, Catherine Hornby, Kelvin Lau   +5 more
doaj   +1 more source

Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1)

Stem Cell Research, 2022
Dyslipidemia is a key modifiable causal risk factor involved in the development of atherosclerotic cardiovascular disease. Recently, the G protein-coupled receptor 146 (GPR146), a member of the G-coupled protein receptors’ family, has been shown to be a ...
Lise Bray, Amandine Caillaud, Aurore Girardeau, Murielle Patitucci, Cédric Le May, Bertrand Cariou, Antoine Rimbert   +6 more
doaj   +1 more source

Automatic multi-organ segmentation in thorax CT images using U-Net-GAN

Medical Imaging, 2019
We propose a method to automatically segment multiple organs at risk (OARs) from routinely-acquired thorax CT images using generative adversarial network (GAN). Multi-label U-Net was introduced in generator to enable end-to-end segmentation.
Y. Lei, Yingzi Liu, Xue Dong, S. Tian, Tonghe Wang, Xiaojun Jiang, Kristin Higgins, J. Beitler, David S. Yu, Tian Liu, W. Curran, Yi Fang, Xiaofeng Yang   +12 more
semanticscholar   +1 more source

The IL-15 / sIL-15Rα complex modulates immunity without effect on asthma features in mouse

Respiratory Research, 2020
Background Interleukin 15 (IL-15) is a growth and modulating factor for B, T lymphocytes and natural killer cells (NK). Its action on innate and adaptive immunity is modulated by its alpha chain receptor (IL-15Rα).
Antoine Moui, Martin Klein, Dorian Hassoun, Eléonore Dijoux, Marie-Aude Cheminant, Antoine Magnan, Grégory Bouchaud   +6 more
doaj   +1 more source