Results 201 to 210 of about 1,449,742 (274)

Role of Longgu () in the compatibility of Chaihu Longgu Muli decoction (chaihulonggudulitang). [PDF]

J Tradit Chin Med
Donghan B, Zi X, Shumin C, Nanxi H, Qiaochu W, Zihao Z, Xueying X, Lu L.   +7 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Evaluation of cyanex272 in the emulsion liquid membrane system for separation of thorium. [PDF]

Sci Rep
Ehyaie D, Zaheri P, Samadfam M, Zahakifar F.   +3 more
europepmc   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Recommendations on the Clinical Application and Future Potential of α-Particle Therapy: A Comprehensive Review of the Results from the SECURE Project. [PDF]

Pharmaceuticals (Basel)
Di Iorio V, Sarnelli A, Boschi S, Sansovini M, Genovese RM, Stefanescu C, Ghizdovat V, Jalloul W, Young J, Sosabowski J, Kolenc P, Roberts R, With G, Visvikis D, Mikolajczak R.   +14 more
europepmc   +1 more source

Chiral‐Nematic Lattice Instability in Charge Density Wave of 1T‐TiSe2

Advanced Science, EarlyView.
The charge density wave of 1T‐TiSe2 appears chiral to surface probes yet loses all symmetry in spectroscopic measurements. This study reveals how cooperative condensation of multiple phonon modes stabilizes a chiral monoclinic ground state, while a shallow nematic energy landscape allows the lattice to break the remaining symmetry at negligible cost ...
Abdurrafi Ahsan Alghifari, Euihwan Do, Jae Whan Park, Han Woong Yeom   +3 more
wiley   +1 more source

Separation of Light and Heavy Rare Earth Elements via Electrospun Supported Liquid Membrane. [PDF]

Polymers (Basel)
Mohd Hizam S, Abd Halim NS, Nik Hanafi NNAZ, Abdul Manaf AS, Wirzal MDH, Mei Quen Y, Mishra S, Dain C.   +7 more
europepmc   +1 more source

Improved Skills for Predicting Sub‐Seasonal to Seasonal Global Sea Surface Temperature

Advanced Science, EarlyView.
Addressing the critical Sub‐seasonal to Seasonal predictability gap, this study presents CAS‐Canglong, a novel deep learning framework. By leveraging 3D Swin‐Transformers to capture long‐range ocean interactions, the model demonstrates superior skill over traditional GCMs.
Longhao Wang, Xuanze Zhang, Ruby L. Leung, Francis H. S. Chiew, Amir AghaKouchak, Kairan Ying, Yongqiang Zhang   +6 more
wiley   +1 more source

An Acylhydrazone Fluorescent Sensor: Bifunctional Detection of Thorium (IV) and Vanadyl Ions over Uranyl and Lanthanide Ions. [PDF]

Int J Mol Sci
Lin X, Liang H, Dai K, Zhou J, Tian Q, Xiang Y, Guo Z, Almásy L.   +7 more
europepmc   +1 more source

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source