Results 51 to 60 of about 389,570 (249)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Biometrika, 1990 The biplot of a two-way table is discussed as a diagnostic tool for investigating bilinear models with additive terms for rows and columns and at least one multiplicative term. The full biplot is three dimensional with the points representing row effects concentrated is a plane orthogonal to another plane containing the points representing the column ...
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Single-Shot 3D Shape Reconstruction Using Structured Light and Deep Convolutional Neural Networks
Sensors, 2020 Single-shot 3D imaging and shape reconstruction has seen a surge of interest due to the ever-increasing evolution in sensing technologies. In this paper, a robust single-shot 3D shape reconstruction technique integrating the structured light technique ...
Hieu Nguyen, Yuzeng Wang, Zhaoyang Wang
doaj +1 more source
Three-dimensional vortex dynamics and transitional flow induced by a circular cylinder placed near a plane wall with small gap ratios [PDF]
, 2022 Jianghua Li +6 more
openalex +1 more source
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
Domain wall and three dimensional duality
Journal of High Energy Physics, 2018 We discuss 1/2 BPS domain walls in the 3d N=4 $$ \mathcal{N}=4 $$ supersymmetric gauge theory which is self-dual under the 3d mirror symmetry. We find that if a BF-type coupling is introduced, invariance of the BPS domain wall under the duality ...
Minoru Eto +2 more
doaj +1 more source
Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins
FEBS Open Bio, EarlyView.We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó +7 more
wiley +1 more source
Designing the image integrated between real reality and holography
Maǧallaẗ Al-Turāṯ wa Al-TaṣmīmThree-dimensional holographic display technology is a sign of future technology and communications. This technology received global attention for the first time in 2008 when first time as a hologram with the aim of reducing the environmental impact of ...
Prof. Dr. Safwat Abdel Halim Prof. Dr. Wael Mohamed Anani Shehab Muhammad Jamal al-Din Qayati
doaj +1 more source