Results 151 to 160 of about 15,354,935 (246)

C–X–C Motif Chemokine Receptor 4 (CXCR4)‐Targeted Biologically Guided Proton Spatially Fractionated Radiotherapy for Bulky Limited‐Stage Small Cell Lung Cancer

open access: yesPrecision Radiation Oncology, EarlyView.
A newly proposed proton spatially fractionated radiotherapy guided by biological imaging Abstract Background and Purpose To evaluate the feasibility and dosimetric safety of integrating C–X–C motif chemokine receptor 4 (CXCR4)‐targeted tracer 18F‐AlF‐NOTA‐QHY‐04 positron emission tomography imaging with biologically guided proton spatially fractionated
Keru Pu   +7 more
wiley   +1 more source

A sample size analysis of a mathematical model of longitudinal tumor volume and progression‐free survival for Bayesian individual dynamic predictions in recurrent high‐grade glioma

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 495-509, March 2025.
Abstract Patients with recurrent high‐grade glioma (rHGG) have a poor prognosis with median progression‐free survival (PFS) of <7 months. Responses to treatment are heterogenous, suggesting a clinical need for prognostic models. Bayesian data analysis can exploit individual patient follow‐up imaging studies to adaptively predict the risk of progression.
Daniel J. Glazar   +5 more
wiley   +1 more source

Intelligent Continuum Micromachines in Complex Confined Spaces

open access: yesSmartBot, EarlyView.
The cover depicts a conceptual design for an intelligent continuum micromachine entering a target capsule used in fusion‐energy research through its slender gas‐fill tube. By combining route‐adaptive deformation, embedded sensing, and a functional end effector, the robot could inspect hidden defects, assess local conditions, and support localized ...
Huayang Sai   +7 more
wiley   +1 more source

Sprayable MXene Hydrogels With Composition‐Driven Interfacial Stabilization and on‐Skin Gelation for Conformal Postsurgical Photothermal Therapy

open access: yesSmall, EarlyView.
A sprayable MXene‐loaded thermosensitive hydrogel was developed for postoperative melanoma treatment. Molecular simulations combined with experimental analyses demonstrated that polymer composition regulates MXene oxidation. The optimized hydrogel effectively preserved photothermal performance under physiological conditions, enabling efficient near ...
Taek Hwang   +15 more
wiley   +1 more source

Smart molecular design of NIR‐II organic fluorophores through self‐driven iterative evolution, deep learning, and fragment‐based assembly

open access: yesSmart Molecules, EarlyView.
A smart design strategy for NIR‐II organic fluorophores is proposed by combining self‐driven Iterative evolution, deep Learning, and fragment‐based assembly. This work establishes a broadly applicable approach for molecular design, accelerating the discovery of NIR‐II fluorophores and extending to optoelectronic materials and therapeutic compounds ...
Yu Zhang   +6 more
wiley   +1 more source

Concurrent tunable structural color, luminescence, and afterglow in single ZnS: X@SiO2 spheres via SiO2‐nanoarmor and calcination decoupling collaborative strategy

open access: yesSmart Molecules, EarlyView.
For the first time, tunable structural color, luminescence, and afterglow are integrated into single ZnS:X@SiO2 spheres via a SiO2‐nanoarmor and calcination decoupling strategy, achieving 250–410 nm monodisperse wurtzite spheres with 91% phase conversion, 12.8% PLQY, and 12.27 s afterglow. Abstract The integration of structural color, photoluminescence,
Tianyi Liu   +3 more
wiley   +1 more source

A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence

open access: yesSmart Molecules, EarlyView.
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen   +8 more
wiley   +1 more source

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