Results 171 to 180 of about 15,354,935 (246)

Intensity-modulated radiation therapy achieves better local control compared to three-dimensional conformal radiation therapy for T4-stage nasopharyngeal carcinoma. [PDF]

Oncotarget, 2017
Chen JL, Huang YS, Kuo SH, Hong RL, Ko JY, Lou PJ, Wang CW.   +6 more
europepmc   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant

British Journal of Pharmacology, EarlyView.
Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley   +1 more source

The Evolution of Radiation Therapy in Children's Oncology Group Trials, From 1998 to 2025. [PDF]

Int J Radiat Oncol Biol Phys
Gallitto M, Zhang H, Iandoli M, Fitzgerald TJ, Kalapurakal JA, Krasin MJ, Haas-Kogan DA, Paulino AC, Laack NNI, Wolden SL, Hoppe BS, Hill-Kayser CE, Mahajan A, Yock TI.   +13 more
europepmc   +1 more source

Advances in Radiotherapy for Neoadjuvant Therapy of Stage III Non‐Small Cell Lung Cancer

Cancer Science, EarlyView.
This review summarizes three neoadjuvant radiotherapy techniques for stage III NSCLC, highlighting SFRT's low‐toxicity dual immune‐tumor control benefits and radioimmunotherapy's superior pathological response to guide precise multimodal treatment. ABSTRACT This review aims to systematically summarize the mechanisms of action, clinical evolution, and ...
Qinrong Mao, Yuanchun Yu, Yan Fang, Shaofeng Zhu, Chengjin Tang, Jing Cai   +5 more
wiley   +1 more source

Evaluation of 3D-CRT vs. VMAT for radiotherapy of whole breast with simultaneous integrated boost. [PDF]

Acta Oncol
Johansson G, Kojoj R, Surdashi S, Olin M, Fredén E, Sen P, Dahl E, Wendt C.   +7 more
europepmc   +1 more source

Defining the role of αC helix interactions in the activation of the integrin αI domain

The FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö, Tomi T. Airenne, Jarmo Käpylä, Hongmin Tu, Eva Bligt‐Lindén, Vimal Parkash, Jyrki Heino, Tiina A. Salminen   +7 more
wiley   +1 more source

Impact of Hydrogel Spacer on Radiation Proctitis After Prostate Cancer Radiation Therapy: A Large-Scale Claims Database Analysis. [PDF]

Adv Radiat Oncol
Takeda K, Okuda S, Umezawa R, Yamamoto T, Takahashi N, Takeda K, Jingu K.   +6 more
europepmc   +1 more source

A dose‐escalated radiation protocol of 10 × 4.0 Gy provides long‐term local control in canine apocrine gland anal sac adenocarcinoma

Journal of Small Animal Practice, EarlyView.
Objectives To obtain insights for establishing radiation therapy strategies that provide long‐term locoregional benefits in canine apocrine gland anal sac adenocarcinoma, we evaluated whether a dose‐escalated protocol (10 × 4.0 Gy) could improve clinical outcomes, particularly long‐term locoregional control, while maintaining acceptable toxicity ...
M. Terauchi, Y. Fujii, R. Iwasaki, T. Mori   +3 more
wiley   +1 more source

Radiotherapy With Hyperthermia for Prostatic Ductal Adenocarcinoma: Primary and Salvage Cases. [PDF]

In Vivo
Matsuura Y, Nakaya D, Tani S, Shimajiri S, Fujimoto N, Ohguri T.   +5 more
europepmc   +1 more source