Results 51 to 60 of about 12,593,924 (215)

Clinico-Dosimetric Correlation Between Lacrimal Gland Dose and Dry Eyes in Three Dimensional Radiotherapy of Brain Tumors [PDF]

Zagazig University Medical Journal
Background: Brain tumors often require radiotherapy as a key component of treatment. While three-dimensional conformal radiotherapy (3D-CRT) provides better dose distribution compared to conventional techniques, organs at risk (OARs) such as the lacrimal
Ebtisam Qasem, Abbas Sarhan, Salma Abd El-Maksoud, Doaa Mandour   +3 more
doaj   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Radiotherapy Techniques and Radiation Pneumonitis: 
A Lot To A Little Or A Little To A Lot?

Chinese Journal of Lung Cancer, 2015
Radiotherapy is one of the main treatment for patients with lung cancer. Three-dimensional conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) are widely used to deliver radiation.
Bingqi YU, Jin WANG, Yujin XU, Feng SU, Guoping SHAN, Ming CHEN   +5 more
doaj   +1 more source

A prospective, comparative analysis of acute toxicity profile between three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) in locally advanced head and neck cancer patients

Cancer Treatment and Research Communications, 2020
Introduction: The advances of modern radiotherapy have emerged with the development of conformal radiotherapy techniques, such as the three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT).
Nilesh Kucha, Tej Prakash Soni, Naresh Jakhotia, Nidhi Patni, Dinesh Kumar Singh, Anil Kumar Gupta, Lalit Mohan Sharma, Jaishree Goyal   +7 more
doaj   +1 more source

Bio‐Memristor Based on Clinical Bile Samples: A Proof‐of‐Concept Pilot Study for Detection of Gallbladder Cancer

Advanced Science, EarlyView.
In this work, we present a bile‐based memristor hardware framework that enables direct, label‐free identification of cholelithiasis and gallbladder cancer at the device level. The Ag/bile/FTO memristor features stable resistive switching and disease‐specific electrical responses, providing a conceptual foundation for circuits and an integrated ERCP ...
Junming Zhu, Yiyin Rong, Bai Sun, Ziwen Sun, Yifan Wang, Xiaobin Ren, Zelin Cao, Kaikai Gao, Jiawei Yu, Zhenkun Wang, Haoxuan Ma, Jichun Guo, Kai Cao, Mengrun Kang, Songling Wang, Fenggang Ren, Yi Lv, Qiang Lu   +17 more
wiley   +1 more source

3D conformal postoperative radiotherapy with concomitant boost in uterine cancer: results of a phase I-II study (ADA-RT-1)

, 2011
A phase I-II prospective clinical trial of adjuvant accelerated radiation therapy (ADA-RT-1 trial) was set up in order to investigate the feasibility and efficacy of a pelvic conformal radiotherapy technique with concomitant boost (CB technique) to the ...
Scambia, Giovanni, Numa Cellini, Ippolito, Edy, Cellini, Numa, Morganti, Alessio Giuseppe, Mariangela Massaccesi, Valentini, Vincenzo, MASSACCESI M, Macchia, Gabriella, Francesco Deodato, Bibbò R, Alessio Giuseppe Morganti, Ferrandina, Maria Gabriella, Massaccesi, Mariangela, IPPOLITO E, CELLINI N, Edy Ippolito, Deodato, Francesco, MACCHIA G, DEODATO F, Romina Bibbò, FERRANDINA G, Gabriella Macchia, Vincenzo Valentini, VALENTINI V, Giovanni Scambia, SCAMBIA G, Valentini, Viola, Gabriella Ferrandina   +28 more
core   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Short‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter propensity score‐matched study of 3213 patients compared intracorporeal (IA) and extracorporeal (EA) anastomosis during minimally invasive colectomy. IA was associated with a significantly lower incidence of intraoperative blood loss ≥ 200 mL (2.5% vs.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Kae Okoshi, Yasunori Deguchi, Keiji Nagata, Tomoaki Okada, Rei Mizuno, Kazutaka Obama   +9 more
wiley   +1 more source

Dosimetric consequences of the shift towards computed tomography guided target definition and planning for breast conserving radiotherapy

Radiation Oncology, 2008
Background The shift from conventional two-dimensional (2D) to three-dimensional (3D)-conformal target definition and dose-planning seems to have introduced volumetric as well as geometric changes.
Korevaar Erik W, Maduro John H, Dolsma Wil V, van der Laan Hans, Langendijk Johannes A   +4 more
doaj   +1 more source