Results 31 to 40 of about 165,542 (311)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Stress intensity factor for small embedded cracks in weldments
Fracture and Structural Integrity, 2019 In the present work, the stress intensity factor (SIF) of embedded small cracks placed at the weld toe is calculated by means of two procedures based on the Oore-Burns integral.
Paolo Livieri, Fausto Segala
doaj +3 more sources
Advances in Civil Engineering, 2020 A small-scale double-hole bench model is designed with granite to study the fracture mechanism of rock blasting. By combining high-speed camera and digital image correlation, the full-field strain characterization and fracture process of the specimen ...
Jun Yang +4 more
doaj +1 more source
Crack avalanches in the three dimensional random fuse model
, 2005 We analyze the scaling of avalanche precursors in the three dimensional random fuse model by numerical simulations. We find that both the integrated and non-integrated avalanche size distributions are in good agreement with the results of the global load
Batrouni +21 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Simple models of the hydrofracture process [PDF]
, 2015 Hydrofracturing to recover natural gas and oil relies on the creation of a fracture network with pressurized water. We analyze the creation of the network in two ways.
Chen, Chih Hung, Marder, M., Patzek, T.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Three Dimensional Analysis Of Non-Planar Crack Propagation Problems
Gazi Üniversitesi Fen Bilimleri Dergisi, 2017 Energy, defence, aeronautics and space technologies are critical for countries and they are the leading areas which promote and require development of science and technology.
Oğuzhan DEMİR, Ali Osman AYHAN
doaj