Results 51 to 60 of about 23,328 (266)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Fatigue Crack Propagation Path and Life Prediction Based on XFEM

Xibei Gongye Daxue Xuebao, 2019
Based on the theory of linear elastic fracture mechanics, the relationships between material constants c3, c4 required in Abaqus and constants C, m in Paris formula are derived.

doaj   +1 more source

Crack coalescence and brittle failure characteristics of open rock bridges

Yantu gongcheng xuebao, 2020
The coalescence of rock bridge of fractured rock mass with end cracking is the main cause of the sudden damage of the rock mass, and the brittle failure is obvious.
CHEN Guo-qing , CHEN Yi 1, SUN Xiang 1, WANG Dong 2, QING Chang-an 1, LIN Zhi-heng 2
doaj   +1 more source

Three-dimensional fracture and fatigue crack propagation analysis in structures with multiple cracks

Computers & Structures, 2015
A procedure is presented for fatigue crack growth simulations of multiple cracks.Stress intensity factors are calculated using three-dimensional enriched elements.During simulations, models are re-meshed to reflect updated crack geometries.Results show excellent agreement when compared with data from the literature.The method can also handle multiple ...
Sakarya Üniversitesi/Mühendislik Fakültesi/Makine Mühendisliği Bölümü, Hakan Dundar, Ayhan, Ali Osman   +2 more
openaire   +3 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Improved 3D characterization of in-situ soil desiccation cracking by multi-source data integration

Geoderma
Desiccation cracking is a common and natural phenomenon under a drought climate. The geometric and morphologic characteristics of the crack pattern are critical to understanding the response of soil mechanical and hydraulic properties to drought climate.
Jun-Zheng Zhang, Chao-Sheng Tang, Wen Mu, Jin-Jian Xu, Qi-You Zhou, Bin Shi   +5 more
doaj   +1 more source