Results 51 to 60 of about 22,441 (265)

Evaluation of Fatigue Crack Front Shape for a Specimen with Finite Thickness

MATEC Web of Conferences, 2015
Two-dimensional elastic or elasto-plastic models dominate the current fatigue crack growth assessment and life prediction procedures for plate components with through-the-thickness cracks.
He Zhuang, Kotousov Andrei, Branco Ricardo   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Calculation and Analysis of Crack Stress Intensity Factor and J Integral of Helical Gear

Jixie chuandong, 2020
The distribution of stress intensity factor and J integral of helical gear with three-dimensional crack under different initial crack parameters is studied. The finite element software is used to analyze the helical gear with initial crack.
Guangyao Sun, Mutellip Ahmat, Pengcheng Wang   +2 more
doaj  

Experimental Study of Three-Dimensional Propagation of Crack in Transparent Rock Mass

Advances in Civil Engineering, 2021
Three-dimensional crack propagation in a rock mass was investigated using a specifically designed material with good transparency and elastoplasticity. The material has properties that are similar to those of the nature sandstone.
Zhende Zhu, Yuan Tian, Xinyu Liu
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Three-dimensional crack propagation simulation based on a nonlocal algorithm of P91 steel under fatigue and creep–fatigue loading

Mechanical Engineering Journal
This study conducted a three-dimensional crack propagation simulation based on a nonlocal algorithm of P91 steel under fatigue and creep–fatigue loading. A damage-coupled inelastic constitutive model incorporating fatigue and creep damage parameters into
Akihiro MOTOKI, Masayuki ARAI
doaj   +1 more source

Crack coalescence and brittle failure characteristics of open rock bridges

Yantu gongcheng xuebao, 2020
The coalescence of rock bridge of fractured rock mass with end cracking is the main cause of the sudden damage of the rock mass, and the brittle failure is obvious.
CHEN Guo-qing , CHEN Yi 1, SUN Xiang 1, WANG Dong 2, QING Chang-an 1, LIN Zhi-heng 2
doaj   +1 more source