Results 51 to 60 of about 165,542 (311)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Experimental Study of Three-Dimensional Propagation of Crack in Transparent Rock Mass
Advances in Civil Engineering, 2021 Three-dimensional crack propagation in a rock mass was investigated using a specifically designed material with good transparency and elastoplasticity. The material has properties that are similar to those of the nature sandstone.
Zhende Zhu, Yuan Tian, Xinyu Liu
doaj +1 more source
Machines, 2022 Dynamic modeling and analysis are generally regarded as effective tools to investigate the vibration characteristics and fault mechanisms of planetary gear systems with a tooth crack fault.
Yi Yang +4 more
doaj +1 more source
Key aspects in 3D fatigue crack closure numerical modelling [PDF]
, 2018 Since long time, fatigue crack closure has been studied by means of finite element models. Initially by bi-dimensional models and recently, due to the higher computational capabilities, the use of three-dimensional models has been extended, providing a
Camas, Daniel +2 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Crack coalescence and brittle failure characteristics of open rock bridges
Yantu gongcheng xuebao, 2020 The coalescence of rock bridge of fractured rock mass with end cracking is the main cause of the sudden damage of the rock mass, and the brittle failure is obvious.
CHEN Guo-qing , CHEN Yi 1, SUN Xiang 1, WANG Dong 2, QING Chang-an 1, LIN Zhi-heng 2
doaj +1 more source
Biaxial stress controlled three-dimensional helical cracks [PDF]
NPG Asia Materials, 2012 Materials are prone to crack under stress — this can either cause materials failure or, when deliberately induced, offer a useful manufacturing step. In both situations, knowing how to control and predict how materials crack will help in their design and synthesis.
Li Wang +8 more
openaire +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source