Results 91 to 100 of about 348,303 (265)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Heads-up surgery with three-dimensional display devices for cataract surgeries. [PDF]
Arq Bras Oftalmol, 2021 Barbosa JP, Ribeiro JC, Machado AJ.
europepmc +1 more source
Redundancy Versus Complexity in Auditory Displays for Object Localization - A Pilot Study [PDF]
, 2011 Presented at the 17th International Conference on Auditory Display (ICAD2011), 20-23 June, 2011 in Budapest, Hungary.Presented at the 17th International Conference on Auditory Display (ICAD2011), 20-23 June, 2011 in Budapest, Hungary.In user interfaces ...
Schultz, Tanja, Constantinescu, Angela
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Three Dimensional Software Modelling [PDF]
, 1998 Traditionally, diagrams used in software systems modelling have been two dimensional (2D). This is probably because graphical notations, such as those used in object-oriented and structured systems modelling, draw upon the topological graph metaphor ...
Gill, J.Y., Kent, Stuart
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Gaze Characteristics Using a Three-Dimensional Heads-Up Display During Cataract Surgery
Journal of Eye Movement ResearchPurpose: An observational study to investigate differences in gaze behaviors across varying expertise levels using a 3D heads-up display (HUD) integrated with eye-tracking was conducted. Methods: 25 ophthalmologists (PGY2–4, fellows, attendings; number(n)
Puranjay Gupta +4 more
doaj +1 more source
Correction: Wu et al. Full-Color See-Through Three-Dimensional Display Method Based on Volume Holography. Sensors 2021, 21, 2698. [PDF]
Sensors (Basel), 2022 Wu T, Ma J, Wang C, Wang H, Su P.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Investigations in coarticulated performance gestures using interactive parameter-mapping 3D sonification [PDF]
, 2015 Presented at the 21st International Conference on Auditory Display (ICAD2015), July 6-10, 2015, Graz, Styria, Austria.Presented at the 21st International Conference on Auditory Display (ICAD2015), July 6-10, 2015, Graz, Styria, Austria.Spatial imagery is
Nymoen, Kristian, Barrett, Natasha
core