Results 51 to 60 of about 24,812,873 (248)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Evaluating models and assessment techniques for understanding oral biofilm complexity
MicrobiologyOpen, 2023 Oral biofilms are three‐dimensional (3D) complex entities initiating dental diseases and have been evaluated extensively in the scientific literature using several biofilm models and assessment techniques.
Srinivas Sulugodu Ramachandra +5 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Three‐dimensional patient‐derived endometriosis model for drug evaluation
Acta Obstetricia et Gynecologica ScandinavicaIntroduction Endometriomsis (EMs) is a complex and chronic gynecological disease characterized by distressing symptoms. Its pathogenesis remains unknown, and there is no effective treatment.
Yuqi Li +10 more
doaj +1 more source
A numerical study of strained three-dimensional wall-bounded turbulence
, 2000 Channel flow, initially fully developed and two-dimensional, is subjected to mean strains that emulate the effect of rapid changes of streamwise and spanwise pressure gradients in three-dimensional boundary layers, ducts, or diffusers.
Coleman, G.N., Spalart, P.R., Kim, J.
core +1 more source
Three-dimensional solid finite element model and mesh division.
, 2023 Three-dimensional solid finite element model and mesh division.
Jianhui Yang (536606)
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
International Journal of General Medicine, 2021 Yuan-Yuan Xing,1,2 Hong-Yuan Xue,2 Yu-Quan Ye1,2 1Hebei Medical University, Shijiazhuang, Hebei, 050017, People’s Republic of China; 2Department of Ultrasound, Hebei General Hospital, Shijiazhuang, 050051, Hebei, People’s Republic of ChinaCorrespondence:
Xing YY, Xue HY, Ye YQ
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source