Results 91 to 100 of about 13,706,163 (294)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Localization and Dualities in Three Dimensional Superconformal Field Theories [PDF]
, 2012 In this thesis we apply the technique of localization to three-dimensional N=2 superconformal field theories. We consider both theories which are exactly superconformal, and those which are believed to flow to nontrivial superconformal fixed points, for
Willett, Brian M.
core +1 more source
Virtual Display System of Geological Body Based on Key Algorithms of Three-dimensional Modelling
Earth Sciences Research Journal, 2019 In order to study the virtual display system of geological body, the key algorithm of three-dimensional modelling is used to analyze it, and the virtual display scheme of geological body is realized.
Wei Feng
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Fast and robust three-dimensional best path phase unwrapping algorithm [PDF]
, 2007 What we believe to be a novel three-dimensional (3D) phase unwrapping algorithm is proposed to unwrap 3D wrapped-phase volumes. It depends on a quality map to unwrap the most reliable voxels first and the least reliable voxels last.
Moore, Christopher J. +5 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The need for the solid modelling of structure in the archaeology of buildings
Internet Archaeology, 1997 Three-dimensional modelling is an attempt to represent the world in three dimensions, simplifying through deliberate assumptions. In archaeology, this has developed as an extension of the traditional use of three-dimensional drawings to help present and ...
Robert Daniels
doaj +1 more source
A novel parallel algorithm for 3D modelling electromagnetic purification of water
MATEC Web of Conferences, 2018 The computational fluid dynamic research in this work has focused on the problem of full-scale three-dimensional modelling water purification processes by the electromagnetic method.
Kudryashova’ Tatiana +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source