Results 81 to 90 of about 13,706,163 (294)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Robust three-dimensional best-path phase-unwrapping algorithm that avoids singularity loops [PDF]

, 2009
In this paper we propose a novel hybrid three-dimensional phase-unwrapping algorithm, which we refer to here as the three-dimensional best-path avoiding singularity loops (3DBPASL) algorithm.
Burton, David, Arevalillo-Herráez, Miguel, Gdeisat, Munther, Abdul-Rahman, Hussein S., Qudeisat, Mohammed, Lilley, Francis, Sheltraw, Daniel, Lalor, Michael, Moore, Christopher   +8 more
core   +1 more source

Two-dimensional multi-spectral digitization and three-dimensional modelling of easel paintings

, 2008
This paper presents the usefulness and utility of three complementary digitisation techniques for the dynamic rendering of colour, roughness and shape of easel paintings.
Colantoni, P., Breuckmann, B., Blais, François, Picard, Michel, Pillay, R., Taylor, John, Rioux, Marc, Cournoyer, Luc, Beraldin, Jean-Angelo, Borgeat, Louis, de Deyne, C., Aitken, G., Lahanier, C.   +12 more
core   +1 more source

SKUF Protocol: Slice, Keep, Unwrap, Fuse—A Pilot Multimodal Approach to Cardiac Innervation Mapping

Diagnostics
Background/Objective: Cardiac innervation plays a critical role in regulating myocardial function and enabling the heart to adapt to physiological and pathological conditions.
Igor Makarov, Olga Solovyova, Anna Starshinova, Dmitry Kudlay, Lubov Mitrofanova   +4 more
doaj   +1 more source

Three-dimensional Finite Element Modelling of the Cylindrical Specimen Upsetting

MATEC Web of Conferences, 2018
Friction has a substantial influence on the metal forming at upsetting of cylindrical aluminum specimens. The finite element method is often used to investigate this problem.
Murashov Mikhail V., Vlasov Andrey V.
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Virtual reality urban modelling - an overview [PDF]

, 2006
This paper offers an overview of the increasing use of Virtual Reality (VR) technologies for the simulation of urban environments. It provides a summary of cities worldwide where three-dimensional computer modelling is being utilised to aid urban ...
Horne, Margaret, Thompson, Emine Mine, E. Thompson, Fleming, David, D. Fleming, M. Horne   +5 more
core  

Sexual Dimorphism of Foetal Sheep Skulls During the Second and Third Periods of Pregnancy

Veterinary Medicine and Science
The skull is a very important structure, and it is the centre of many vital functions. There have been many studies on the skulls of mammals, but not many studies on the prenatal period.
Barış Can Güzel, Fatma Işbilir
doaj   +1 more source

Three-Dimensional Modelling and Simulation Theory of Field Effect Devices

Active and Passive Electronic Components, 1999
In recent years, semiconductor manufacturers have been able to steadily reduce the physical area required by devices, thus allowing an increasing number of circuit functions on a single chip.
M. N. Doja, Moinuddin, Umesh Kumar
doaj   +1 more source