Results 31 to 40 of about 3,186,854 (184)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Tomographic reconstruction of the three-dimensional structure of the HH30 jet

, 2010
The physical parameters of Herbig-Haro jets are usually determined from emission line ratios, obtained from spectroscopy or narrow band imaging, assuming that the emitting region is homogeneous along the line of sight.
A. C. Raga, Anglada, Aster, Bacciotti, Bacciotti, Bacciotti, Bacciotti, Beck, Brown, Burrows, C. del Burgo, Carroll, Coffey, Coffey, Craig, De Colle, F. De Colle, Ferreira, Hartigan, Lavalley-Fouquet, Lery, Lovelace, Mundt, Ray, Ray, Reipurth, Shu, Shu, Yirak   +28 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Electronic Structure of Three-Dimensional Superlattices Subject to Tilted Magnetic Fields

, 2005
Full quantum-mechanical description of electrons moving in 3D structures with unidirectional periodic modulation subject to tilted magnetic fields requires an extensive numerical calculation.
E. I. Blount, G. Bastard, J. Hu, J. Kučera, K. Kobayashi, K. Výborný, L. Esaki, L. Onsager, L. Smrčka, N. A. Goncharuk, N. W. Ashcroft, O. Jaschinski, S. Bujkewicz, S. G. Davidson, T. Osada, T. Osada, T. Osada, W. G. Chambers   +17 more
core   +1 more source

The three-dimensional structure of the Eta Carinae Homunculus [PDF]

, 2014
We investigate, using the modeling code SHAPE, the three-dimensional structure of the bipolar Homunculus nebula surrounding Eta Carinae, as mapped by new ESO VLT/X-Shooter observations of the H2 $\lambda=2.12125$ micron emission line.
Corcoran, M. F., Damineli, A., Groh, J. H., Gull, T. R., Hamaguchi, K., Madura, T. I., Mehner, A., Steffen, W., Teodoro, M.   +8 more
core   +3 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Three-Dimensional Gravity and String Ghosts

, 1991
It is known that much of the structure of string theory can be derived from three-dimensional topological field theory and gravity. We show here that, at least for simple topologies, the string diffeomorphism ghosts can also be explained in terms of ...
A. Hosoya, E. Witten, E. Witten, E. Witten, G. Moore, H. Verlinde, I. I. Kogan, I. I. Kogan, I. I. Kogan, J. A. Wheeler, J. A. Wheeler, J. W. York, R. F. Baierlein, S. Carlip, S. Carlip, S. Carlip, S. Carlip, S. Carlip, S. Carlip, S. Deser, S. Deser, S. Elitzur, V. Moncrief   +22 more
core   +1 more source

Glyoxal 4-nitrophenylhydrazone : triple helices linked into a three-dimensional channel structure [PDF]

, 2005
Peer reviewedPublisher ...
Glidewell, C, Low, J N, Skakle, Jan, Wardell, J L   +3 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Three Dimensional Structure and Energy Balance of a Coronal Mass Ejection

, 2008
The Ultraviolet Coronagraph Spectrometer (UVCS) observed Doppler shifted material of a partial Halo Coronal Mass Ejection (CME) on December 13 2001. The observed ratio of [O V]/O V] is a reliable density diagnostic important for assessing the state of ...
Akmal, Chen, Ciaravella, Ciaravella, Ciaravella, Dere, Howard, J. C. Raymond, J.-Y. Lee, K.-S. Kim, Ko, Krall, Krall, Landi, Lee, Lynch, Lynch, Michalek, Rakowski, Raymond, Shiota, Vourlidas, Y.-K. Ko   +22 more
core   +1 more source