Results 71 to 80 of about 208 (185)

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real‐world clinical‐practice study

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva, Elena González‐Alguacil, Patricia Smeyers, Sara Hernández, Victor Soto‐Insuga, Alejandro Fernández‐Cabrera, Laura Olivié, Teresa de Santos, Beatriz Parejo, Lucas Iacampo, Belén Ortuño, Javier Aparicio, Montserrat Fuentes, Juan Rodriguez‐Uranga, Paula Martínez‐Agredano, José Carlos Estévez, Angel Aledo‐Serrano, Rocio Martin‐Alvarez, David Conejo, Belen Baena, Blanca Mercedes‐Álvarez, Yolanda López, Alba Sierra‐Marcos, Rocio Trincado‐Lamuño, Mouna Ennazeh, Jesús González de la Aleja, Julia Renau, Maria Dolores Castro‐Vilanova, Fátima Romero‐Aguilera, José M. Serratosa   +29 more
wiley   +1 more source

Antiseizure potency and neurotoxicity of the enantiomers of fenfluramine and norfenfluramine in rats and correlations with their concentrations in plasma and brain

Epilepsia, EarlyView.
Abstract Objective Based on the evidence that fenfluramine‐induced anorexia, weight loss, and cardiovascular toxicity are primarily mediated by the d‐enantiomers of fenfluramine and its metabolite norfenfluramine, we investigated pharmacokinetic/pharmacodynamic correlations for the active enantiomers of fenfluramine and norfenfluramine in the rat ...
Yara Sheeni, Dinorah Barasch, Tawfeeq Shekh‐Ahmad, Emilio Perucca, Meir Bialer   +4 more
wiley   +1 more source

Hybrid Inverters With Dual Switching Frequencies for Switched Reluctance Motors

Energy Science &Engineering, EarlyView.
A hybrid dual‐switching‐frequency inverter for SRMs is proposed, combining SiC and IGBT devices based on rotor inductance. The method enables accurate current tracking with simple hysteresis control, significantly reducing torque ripple, vibration, and acoustic noise while cutting inverter cost compared to full‐SiC solutions.
Fares S. El‐Faouri, Majd G. Batarseh, Hamzeh J. Jaber, Ayman Faza, Wejdan Abu Elhaija   +4 more
wiley   +1 more source

Materials and Music: Selective Imperfection as a Generative Framework for Analysis, Creativity and Discovery

Interdisciplinary Materials, EarlyView.
Vibrations in matter, from spider webs to molecules, water to flames, share a grammar with music. We propose that creativity emerges when constraints force expansion beyond existing possibilities. Selective imperfection restores balance, enabling invention.
Markus J. Buehler
wiley   +1 more source

Control for a DC Microgrid for Photovoltaic–Wind Generation with a Solid Oxide Fuel Cell, Battery Storage, Dump Load (Aqua-Electrolyzer) and Three-Phase Four-Leg Inverter (4L4W)

Clean Technologies
This paper proposes a nonlinear control strategy for a microgrid, comprising a PV generator, wind turbine, battery, solid oxide fuel cell (SOFC), electrolyzer, and a three-phase four-leg voltage source inverter (VSI) with an LC filter.
Krakdia Mohamed Taieb, Lassaad Sbita
doaj   +1 more source

Spatiotemporal dynamics of brain function network during proprioception rehabilitation after anterior cruciate ligament reconstruction: A randomized trial

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
The improvement of proprioceptive function after ACLR is related to the optimization of spatiotemporal dynamics of SM, CC, DM, CB and VI functional networks. Rehabilitation optimization can incorporate visual–cognitive dual‐task exercises. Abstract Purpose In this study, we aimed to examine the dynamic functional network connectivity (dFNC) patterns ...
Xiaoyun Zhuang, Chunmei Sui, Xuesong Han, Xiaoying Liu, Xiaoyang Wang, Xiumei Zhu, Ming Xu, Yin Qin   +7 more
wiley   +1 more source

Space Vector Modulation Technique to Reduce Leakage Current of a Transformerless Three-Phase Four-Leg Photovoltaic System

Iranian Journal of Electrical and Electronic Engineering, 2017
Photovoltaic systems integrated to the grid have received considerable attention around the world. They can be connected to the electrical grid via galvanic isolation (transformer) or without it (transformerless).
F. Hasanzad, H. Rastegar, G. B. Gharehpetian, M. Pichan   +3 more
doaj  

NKX2‐1 Downstream Regulatory Structural Variants Explain a Substantial Proportion of Molecular Diagnoses in Patients With Benign Hereditary Chorea

Movement Disorders, EarlyView.
Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard, Lucy Dougherty‐de Miguel, German Demidov, Galuh Astuti, Amaia Lasa‐Aranzasti, Ana Cueto‐González, Marta Correa‐Vela, Carlos Lázaro‐Hernández, Charlotte A. Haaxma, Clara D.M. van Karnebeek, David Gómez‐Andrés, Ignacio Iglesias‐Serrano, Jiddeke M. van de Kamp, Jolanda Schieving, Laura Trujillano, Marc Engelen, Beatriz Muñoz‐Cabello, Roderick P.P.W.M. Maas, Thatjana Gardeitchik, Victoria Gonzalez, Annemarie de Vreugd, Cristina Pérez‐Sanchez, Elisabet Lloveras, Erik‐Jan Kamsteeg, Maartje Pennings, Natalia Rey‐Viñets, Javier Sánchez, Ronald van Beek, Antonio Moreno‐Galdó, Lisenka E.L.M. Vissers, Kornelia Neveling, Anna Marcé‐Grau, Machteld M. Oud, Belén Pérez‐Dueñas   +33 more
wiley   +1 more source

Hexapod Locomotion Across Structured and Unstructured Terrains: A Data‐Driven Review of Modeling, Control, and Validation

Journal of Field Robotics, EarlyView.
ABSTRACT The design of a hexapod is complex and requires integration between kinematic models, control systems, and sensing. Existing literature has reviewed these sub‐systems in isolation. Since 2021, there has been no review of the field despite significant advancements in soft soil, lunar traversal, and artificial intelligence.
Akhil Rampersad, Bashan Naidoo
wiley   +1 more source

Coordinated compensation of three-phase imbalance and DC second harmonic in flexible distribution networks: a multiplexed-leg three-phase four-legs converter approach

Engineering Science and Technology, an International Journal
Large-scale and uncoordinated integration of distributed photovoltaics and electric vehicle chargers in sustainable distribution networks significantly aggravates three-phase imbalance, resulting in double-frequency power oscillations on the AC side ...
Peng Wang, Chao Zhang, Xufeng Yuan, Wei Xiong, ZhiYang Lu, Huajun Zheng, Yutao Xu, Zhukui Tan   +7 more
doaj   +1 more source