Results 111 to 120 of about 242 (201)
The Perspectives of the Three Seas Initiative in Overcoming the Economic Disparities in Europe
Proceedings of the International Conference on Business ExcellenceAbstract The Three Seas Initiative has the potential to change the economic model and dynamics in European geopolitics. Aiming at infrastructure development, energy, and digital connectivity, the initiative aims to address some of the main challenges facing Central and Eastern Europe, while also contributing to the broader goals of ...
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
“East-West” Convergence through “North-South” Connectivity: A Decade of the Three Seas Initiative’s Contribution to the European Union [PDF]
Romanian Journal of European AffairsCreated in a region long marred by historical fracture – self-positioned as Central-European, yet deemed peripheral in inertial cartographies –, the Three Seas Initiative (3SI) has emerged as a quietly potent framework for transforming a once marginal ...
Octavian-Dragomir Jora +3 more
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Estonian Priority Projects in the Three Seas Initiative 2018–2024
Studia PolityczneThe aim of the article is to introduce the Estonian priority projects submitted under the Three Seas Initiative (3SI), in the period 2018–24, and to answer the research question: whether there is a convergence between the assumptions of the Estonian priority projects and the strategic objectives of the Initiative, which are: improvement in the area of ...
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