Results 61 to 70 of about 514,103 (332)
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Layer Performance Recovery After Feeding Amino Acid-deficient Diets [PDF]
Brazilian Journal of Poultry Science, 2002 Three hundred and twenty Hy-Line W36Ò commercial laying hens, 39 weeks of age, were used to determine the sequence and the length of time needed for hens to recover performance characteristics after an eight-week period under graded levels of threonine ...
DE Faria, RH Harms, GB Russell
doaj +1 more source
Threonine Is Catabolized by L-Threonine 3-Dehydrogenase and Threonine Dehydratase in Hepatocytes from Domestic Cats (Felis domestica) [PDF]
The Journal of Nutrition, 1996 Isolated hepatocytes were used to study threonine catabolism in kittens, and dietary threonine and crude protein were varied to study enzyme adaptation. Cells were isolated from 21-wk-old kittens which had been fed diets containing threonine at 4 or 8 g/kg of diet with either 200 or 500 g crude protein/kg of diet (2 x 2 factorial, n = 4/group ...
Quinton R. Rogers +2 more
openaire +3 more sources
Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus: sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH2-Gly3 substrates [PDF]
, 2000 Staphylococcus aureus sortase anchors surface proteins to the cell wall envelope by cleaving polypeptides at the LPXTG motif. Surface proteins are linked to the peptidoglycan by an amide bond between the C-terminal carboxyl and the amino group of the ...
Faull, Kym F. +3 more
core
Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides [PDF]
, 2016 The success of inhibition of the proteasome by formation of covalent bonds is a major victory over the long held-view that this would lead to binding the wrong targets and undoubtedly lead to toxicity.
Brouwer, Arwin J. +4 more
core +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
L-Threonine Supplementation During Colitis Onset Delays Disease Recovery
Frontiers in Physiology, 2018 Dietary nutrients have emerged as potential therapeutic adjuncts for inflammatory bowel disease (IBD) given their impact on intestinal homeostasis through the modulation of immune response, gut microbiota composition and epithelial barrier stability ...
Joana Gaifem +19 more
doaj +1 more source
Overproduction of threonine by Saccharomyces cerevisiae mutants resistant to hydroxynorvaline [PDF]
, 1992 In this work, we isolated and characterized mutants that overproduce threonine from Saccharomyces cerevisiae. The mutants were selected for resistance to the threonine analog a-amino-13-hydroxynorvalerate (hydroxynorvaline), and,
López Calderón, Isabel +1 more
core +1 more source
Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou +11 more
wiley +1 more source
Experimental Biology and Medicine, 1939 Criegee, Kraft and Rank1 showed that glycols and related compounds are split by lead tetraacetate to yield ketones or aldehydes. Threonine (CH3CHOHCHNH2COOH) should, therefore, yield acetaldehyde when oxidized by lead tetraacetate. Eegriwe2 described a highly sensitive color reaction for the qualitative estimation of lactic acid based upon the ...
Richard J. Block, Diana Bolling
openaire +2 more sources