Results 61 to 70 of about 604,484 (380)

A model organism pipeline provides insight into the clinical heterogeneity of TARS1 loss-of-function variants

open access: yesHGG Advances
Summary: Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes that complete the first step of protein translation: ligation of amino acids to cognate tRNAs.
Rebecca Meyer-Schuman   +11 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus: sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH2-Gly3 substrates [PDF]

open access: yes, 2000
Staphylococcus aureus sortase anchors surface proteins to the cell wall envelope by cleaving polypeptides at the LPXTG motif. Surface proteins are linked to the peptidoglycan by an amide bond between the C-terminal carboxyl and the amino group of the ...
Faull, Kym F.   +3 more
core  

Bacterial catabolism of threonine. Threonine degradation initiated by l-threonine hydro-lyase (deaminating) in a species of Corynebacterium [PDF]

open access: yesBiochemical Journal, 1977
1. Three bacterial isolates capable of growth on l-threonine medium only when supplemented with branched-chain amino acids, and possessing high l-threonine dehydratase activity, were examined to elucidate the catabolic route for the amino acid. 2. Growth, manometric, radiotracer and enzymic experiments indicated that l-threonine was catabolized by ...
Stephen C. Bell, John M. Turner
openaire   +3 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Threonine Is Catabolized by L-Threonine 3-Dehydrogenase and Threonine Dehydratase in Hepatocytes from Domestic Cats (Felis domestica) [PDF]

open access: yesThe Journal of Nutrition, 1996
Isolated hepatocytes were used to study threonine catabolism in kittens, and dietary threonine and crude protein were varied to study enzyme adaptation. Cells were isolated from 21-wk-old kittens which had been fed diets containing threonine at 4 or 8 g/kg of diet with either 200 or 500 g crude protein/kg of diet (2 x 2 factorial, n = 4/group ...
Quinton R. Rogers   +2 more
openaire   +3 more sources

Two‐stage carbon distribution and cofactor generation for improving l‐threonine production of Escherichia coli

open access: yesBiotechnology and Bioengineering, 2018
L‐Threonine, a kind of essential amino acid, has numerous applications in food, pharmaceutical, and aquaculture industries. Fermentative l‐threonine production from glucose has been achieved in Escherichia coli.
Jiaheng Liu   +8 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Chirality Transfer and Oxazolidine Formation in Reaction of L and D Enantiomers of β-Hydroxy Amino Acids with Nitrogenous Carboxaldehydes and Nickel(II)

open access: yesMolecules
The reaction of either the L (2S3R) or D (2R3S) enantiomers of H2N-C*H(R)CO2− (R = -C*H(OH)CH3 or -C*H(OH)CH(CH3)2) and the L (2S) or D (2R) enantiomers of H2N-C*H(C(CH3)2OH)CO2− with imidazole-4-carboxaldehyde and nickel(II) acetate in methanol yields a
Cynthia T. Brewer   +2 more
doaj   +1 more source

Post-hatch L-Threonine Supplementation to Low Protein Diets Influences the Growth Performance and Immune Response of CARIBRO Vishal broiler Chickens

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
Two experiments were conducted to evaluate growth performance, immune responses and carcass traits of CARIBRO Vishal broilers fed dietary L-Thr in low protein diets without or with the balance of Lys and Met.
Joel O Alabi   +8 more
doaj  

Home - About - Disclaimer - Privacy