Results 61 to 70 of about 521,154 (335)

A synopsis of recent work on the amino acid nutrition of layers1

Journal of Applied Poultry Research, 2021
Summary: This review, a summation of work presented at the Virtual 2020 Poultry Science Association Annual Meeting, addresses changes in laying hen performance and techniques to manage hens that require fine-tuning amino acid minimums.
M.T. Kidd, R.E. Loar, II
doaj  

Threonine Is Catabolized by L-Threonine 3-Dehydrogenase and Threonine Dehydratase in Hepatocytes from Domestic Cats (Felis domestica) [PDF]

The Journal of Nutrition, 1996
Isolated hepatocytes were used to study threonine catabolism in kittens, and dietary threonine and crude protein were varied to study enzyme adaptation. Cells were isolated from 21-wk-old kittens which had been fed diets containing threonine at 4 or 8 g/kg of diet with either 200 or 500 g crude protein/kg of diet (2 x 2 factorial, n = 4/group ...
Quinton R. Rogers, Richard A. Freedland, Victoria A. Hammer   +2 more
openaire   +3 more sources

Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus: sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH2-Gly3 substrates [PDF]

, 2000
Staphylococcus aureus sortase anchors surface proteins to the cell wall envelope by cleaving polypeptides at the LPXTG motif. Surface proteins are linked to the peptidoglycan by an amide bond between the C-terminal carboxyl and the amino group of the ...
Faull, Kym F., Mazmanian, Sarkis K., Schneewind, Olaf, Ton-That, Hung   +3 more
core  

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Threonine Phosphorylation and the Yin and Yang of STAT1: Phosphorylation-Dependent Spectrum of STAT1 Functionality in Inflammatory Contexts

Cells
Threonine phosphorylation promotes inflammatory functions of STAT1 while restricting its interferon (IFN) signaling in innate immune responses. However, it remains unclear whether the restriction of STAT1-mediated IFN signaling conferred by threonine ...
Maha M. Elbrashy, Hozaifa Metwally, Shuhei Sakakibara, Tadamitsu Kishimoto   +3 more
doaj   +1 more source

L-Threonine Supplementation During Colitis Onset Delays Disease Recovery

Frontiers in Physiology, 2018
Dietary nutrients have emerged as potential therapeutic adjuncts for inflammatory bowel disease (IBD) given their impact on intestinal homeostasis through the modulation of immune response, gut microbiota composition and epithelial barrier stability ...
Joana Gaifem, Joana Gaifem, Luís G. Gonçalves, Ricardo J. Dinis-Oliveira, Ricardo J. Dinis-Oliveira, Ricardo J. Dinis-Oliveira, Cristina Cunha, Cristina Cunha, Agostinho Carvalho, Agostinho Carvalho, Egídio Torrado, Egídio Torrado, Fernando Rodrigues, Fernando Rodrigues, Margarida Saraiva, Margarida Saraiva, António G. Castro, António G. Castro, Ricardo Silvestre, Ricardo Silvestre   +19 more
doaj   +1 more source

Determination of Threonine

Experimental Biology and Medicine, 1939
Criegee, Kraft and Rank1 showed that glycols and related compounds are split by lead tetraacetate to yield ketones or aldehydes. Threonine (CH3CHOHCHNH2COOH) should, therefore, yield acetaldehyde when oxidized by lead tetraacetate. Eegriwe2 described a highly sensitive color reaction for the qualitative estimation of lactic acid based upon the ...
Richard J. Block, Diana Bolling
openaire   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Effects of Dietary Levels of Glycine, Threonine and Protein on Threonine Efficiency and Threonine Dehydrogenase Activity in Hepatic Mitochondria of Chicks [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
This study was carried out to evaluate the relationship between threonine (Thr) efficiency and Thr dehydrogenase (TDG) activity as an indicator of Thr oxidation on chicks fed with levels of diets (CP [17.5% and 21.5%] and Thr [3.8 and 4.7 g/100 g CP]; glycine [Gly][0.64% and 0.98%] and true digestible Thr [dThr] [0.45% and 0.60%]).
Suk Kim, Yu Jin Lee, Yong Tae Ahn, Yonghae Son, I. Kwak, Won-Gun An, I. J. Cho, Chul-Won Lee   +7 more
openaire   +5 more sources