Results 61 to 70 of about 611,533 (383)

A model organism pipeline provides insight into the clinical heterogeneity of TARS1 loss-of-function variants

HGG Advances
Summary: Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes that complete the first step of protein translation: ligation of amino acids to cognate tRNAs.
Rebecca Meyer-Schuman, Allison R. Cale, Jennifer A. Pierluissi, Kira E. Jonatzke, Young N. Park, Guy M. Lenk, Stephanie N. Oprescu, Marina A. Grachtchouk, Andrzej A. Dlugosz, Asim A. Beg, Miriam H. Meisler, Anthony Antonellis   +11 more
doaj   +1 more source

A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor [PDF]

, 2008
Understanding the gating mechanism of the nicotinic acetylcholine receptor (nAChR) and similar channels constitutes a significant challenge in chemical neurobiology.
Dougherty, Dennis A., Hanek, Ariele P., Lester, Henry A.   +2 more
core  

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus: sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH2-Gly3 substrates [PDF]

, 2000
Staphylococcus aureus sortase anchors surface proteins to the cell wall envelope by cleaving polypeptides at the LPXTG motif. Surface proteins are linked to the peptidoglycan by an amide bond between the C-terminal carboxyl and the amino group of the ...
Faull, Kym F., Mazmanian, Sarkis K., Schneewind, Olaf, Ton-That, Hung   +3 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis [PDF]

, 2003
Indexación: ScieloWe report here the complete genomic sequence of the Chilean human isolate of Andes virus CHI-7913. The S, M, and L genome segment sequences of this isolate are 1,802, 3,641 and 6,466 bases in length, with an overall GC content of 38.7%.
Fernández, Jorge, Galeno, Héctor, Martínez, Rodrigo, Mora, Judith, Müller, Ilse, Ramírez, Eugenio, Rosemblatt, Mario, Tischler, Nicole D., Valenzuela, Pablo D.T., Villagra, Eliecer   +9 more
core   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Chirality Transfer and Oxazolidine Formation in Reaction of L and D Enantiomers of β-Hydroxy Amino Acids with Nitrogenous Carboxaldehydes and Nickel(II)

Molecules
The reaction of either the L (2S3R) or D (2R3S) enantiomers of H2N-C*H(R)CO2− (R = -C*H(OH)CH3 or -C*H(OH)CH(CH3)2) and the L (2S) or D (2R) enantiomers of H2N-C*H(C(CH3)2OH)CO2− with imidazole-4-carboxaldehyde and nickel(II) acetate in methanol yields a
Cynthia T. Brewer, Greg Brewer, Raymond J. Butcher   +2 more
doaj   +1 more source

Post-hatch L-Threonine Supplementation to Low Protein Diets Influences the Growth Performance and Immune Response of CARIBRO Vishal broiler Chickens

Scientific Papers Animal Science and Biotechnologies, 2023
Two experiments were conducted to evaluate growth performance, immune responses and carcass traits of CARIBRO Vishal broilers fed dietary L-Thr in low protein diets without or with the balance of Lys and Met.
Joel O Alabi, Subrat K Bhanja, Adeboye O Fafiolu, Okanlawon M Onagbesan, Akshat Goel, Manish Mehra, Ifeoluwa D Dada, Oluremi A Osinowo, Oluseyi O Oluwatosin   +8 more
doaj  

Two‐stage carbon distribution and cofactor generation for improving l‐threonine production of Escherichia coli

Biotechnology and Bioengineering, 2018
L‐Threonine, a kind of essential amino acid, has numerous applications in food, pharmaceutical, and aquaculture industries. Fermentative l‐threonine production from glucose has been achieved in Escherichia coli.
Jiaheng Liu, Huiling Li, Hui Xiong, Xixian Xie, N. Chen, Guang-Rong Zhao, Qinggele Caiyin, Hongji Zhu, Jianjun Qiao   +8 more
semanticscholar   +1 more source