Results 71 to 80 of about 548,221 (334)

PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]

, 2020
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun, Choi, Jeong-Won, Choi, Sun Sil, Eom, Hye-Jin, Hyun, Ji-Min, Jang, Hyun-Jun, Khim, Keon Woo, Lee, Eujin, Lee, Yo Han, Nam, Dougu, Park, Tae-Eun, Yoon, Sora   +11 more
core   +1 more source

Effects of high dietary threonine supplementation on growth performance, health biomarkers, and intestinal histology in cyclic heat-stressed broilers [PDF]

Veterinary World
Background and Aim: Heat stress (HS) negatively impacts poultry production by reducing growth performance and compromising physiological health. Nutritional strategies, particularly amino acid supplementation, are explored to mitigate these adverse ...
Abia Khalid, Sania Bashir, Asma Kalsoom, Hafiz Faseeh Ur Rehman, Muhammad Afzal Rashid, Mansur Abdullah Sandhu, Habib Ur Rehman, Muhammad Shahbaz Yousaf   +7 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells [PDF]

, 2010
The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism. During T lymphocyte development in the thymus, progenitors need to synchronize increased metabolism with the onset of proliferation and ...
Aifantis, Aifantis, Alessi, Azzam, Bonaccorsi, Borowski, Boudeau, Bozulic, Cantrell, Cantrell, Cantrell, Chang, Choi, Ciofani, Ciofani, de Pooter, Frauwirth, Goldstein, Hardie, Hardie, Hayday, Hemminki, Hezel, Hinton, Hurov, Hurov, Ji, Jones, Juntilla, Kelly, Koo, Laky, Lee, Liang, Lizcano, Mao, Mayer, Michie, Mirouse, Partanen, Rodewald, Sakamoto, Sanchez-Cespedes, Schmitt, Shaw, Shaw, Smith-Garvin, Takahama, Takahama, Tamas, Ylikorkala   +50 more
core   +5 more sources

Effect of different threonine to lysine (threonine/lysine) ratios on growth performance and carcass composition in growth-finishing swine

浙江大学学报. 农业与生命科学版, 2003
Ninety-six Duroc-Landrace-Yorkshire piglets which weighed about 28kg were randomly divided into four groups to be used in studying the different ratios of threonine to lysine (0.62, 0.67, 0.72 and 0.78) on growth performance and carcass composition in ...
FENG Jie, XU Zi-rong
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Threonine Phosphorylation and the Yin and Yang of STAT1: Phosphorylation-Dependent Spectrum of STAT1 Functionality in Inflammatory Contexts

Cells
Threonine phosphorylation promotes inflammatory functions of STAT1 while restricting its interferon (IFN) signaling in innate immune responses. However, it remains unclear whether the restriction of STAT1-mediated IFN signaling conferred by threonine ...
Maha M. Elbrashy, Hozaifa Metwally, Shuhei Sakakibara, Tadamitsu Kishimoto   +3 more
doaj   +1 more source

Interactive effects of threonine levels and protein source on growth performance and carcass traits, gut morphology, ileal digestibility of protein and amino acids, and immunity in broilers

Poultry Science, 2020
: An experiment was executed to test the hypothesis that supplementation of dietary threonine (d-Thr), above NRC recommendation to diets containing poorly digestible protein source (PS) may compensate its detrimental effects on overall performance of ...
I. Ahmed, S.N. Qaisrani, F. Azam, T.N. Pasha, F. Bibi, S. Naveed, S. Murtaza   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]

, 2017
The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core   +1 more source