Results 61 to 70 of about 52,600 (247)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A model organism pipeline provides insight into the clinical heterogeneity of TARS1 loss-of-function variants

HGG Advances
Summary: Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes that complete the first step of protein translation: ligation of amino acids to cognate tRNAs.
Rebecca Meyer-Schuman, Allison R. Cale, Jennifer A. Pierluissi, Kira E. Jonatzke, Young N. Park, Guy M. Lenk, Stephanie N. Oprescu, Marina A. Grachtchouk, Andrzej A. Dlugosz, Asim A. Beg, Miriam H. Meisler, Anthony Antonellis   +11 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Effects of dietary protein and threonine supply on in vitro liver threonine dehydrogenase activity and threonine efficiency in rat and chicken

, 2022
S.1417-1424This study was conducted to assess the relation between threonine (Thr) oxidation rate and threonine efficiency on rat and chicken fed with graded levels of protein and threonine.
Oh, Y.J., An, W.G., Lee, C.W., Son, Y.S.
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

EFECTO DE VARIOS NIVELES DE TREONINA: LISINA SOBRE PARAMÉTROS PRODUCTIVOS EN CERDOS EN FINALIZACION TRATADOS CON RACTOPAMINA EFFECT OF VARIOUS LEVELS OF THREONINE: LYSINE ON PRODUCTION PARAMETERS IN FINISHING PIGS TREATED WITH RACTOPAMINE

Revista Facultad Nacional de Agronomía Medellín, 2008
Para determinar el efecto de la adición de Ractopamina (RAC) y la relación Treonina:Lisina (Thr:Lys) sobre los rendimientos productivos, se realizó un experimento durante 28 días.
Jaime Eduardo Parra Suescún, Hernán Alonso Echavarría Sánchez   +1 more
doaj  

Post-hatch L-Threonine Supplementation to Low Protein Diets Influences the Growth Performance and Immune Response of CARIBRO Vishal broiler Chickens

Scientific Papers Animal Science and Biotechnologies, 2023
Two experiments were conducted to evaluate growth performance, immune responses and carcass traits of CARIBRO Vishal broilers fed dietary L-Thr in low protein diets without or with the balance of Lys and Met.
Joel O Alabi, Subrat K Bhanja, Adeboye O Fafiolu, Okanlawon M Onagbesan, Akshat Goel, Manish Mehra, Ifeoluwa D Dada, Oluremi A Osinowo, Oluseyi O Oluwatosin   +8 more
doaj  

Threonine metabolism in sheep [PDF]

British Journal of Nutrition, 1983
1. The irreversible loss rate (ILR) of glucose, bicarbonate and threonine were determined in six twin- and triplet-bearing ewes on three occasions during the last 6 weeks of gestation.2. Three of the ewes (group S) were given conventional rations of hay plus concentrates so that their blood ketone levels did not rise over this period.
J C, MacRae, A R, Egan
openaire   +2 more sources

Dietary Threonine Requirement Of Indian Major Carp, Cirrhinus Mrigala (Hamilton), Juveniles [PDF]

, 2002
A growth study was conducted to determine the dietary threonine requirement of juveniles of the Indian major carp (Cirrhinus mrigala) known as “mrigal”. Diets containing casein and gelatin as sources of intact proteins were supplemented with crystalline ...
Benakappa, S., Varghese, T.J.
core