Molecular Evolution of Threonine Dehydratase in Bacteria [PDF]
PLoS ONE, 2013 Threonine dehydratase converts L-threonine to 2-ketobutyrate. Several threonine dehydratases exist in bacteria, but their origins and evolutionary pathway are unknown.
Xiaoyuan Wang
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Precise l-threonine-to-l-isoleucine pathway regulation for engineering high-efficiency whole-cell biocatalysts [PDF]
Synthetic and Systems Biotechnologyl-Isoleucine (L-Ile), a critical branched-chain amino acid with diverse applications in food, pharmaceutical, and cosmetic industries, is difficult to produce efficiently at scale in microbial systems due to metabolic bottlenecks and cofactor limitations.
Heng Zhang +6 more
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Multi-omics analysis reveals the mechanism of Huaganjian in alleviating cholestatic liver fibrosis [PDF]
Frontiers in PharmacologyHuaganjian (HGJ) is a traditional Chinese medicinal formula with liver-protective effects. However, the pharmacological mechanisms of the effects of HGJ on cholestatic liver fibrosis (CLF) are yet to be clarified.
Zijun Zhang +3 more
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Amino acid metabolism of the thermophilic acetogen Thermacetogenium phaeum. [PDF]
PLoS ONEAnaerobic microbial degradation of the amino acids glycine and serine either occurs through enzymes of the so-called Stickland reaction or alternatively through the glycine cleavage system (GCS).
Yanlin Cai +3 more
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The Role of Threonine Deaminase/Dehydratase in Winter Dormancy in Sweet Cherry Buds
Nitrogen, 2023 The determination of the endodormancy release and the beginning of ontogenetic development is a challenge, because these are non-observable stages. Changes in protein activity are important aspects of signal transduction. The conversion of threonine to 2-
Frank-M. Chmielewski +2 more
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Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species [PDF]
Advanced ScienceThe tetramic acid moiety is a pivotal structural unit in numerous natural products. As an analogue of the simplest tetramic acid compound tenuazonic acid (TeA), sec‐pentyl‐TeA (S‐TeA) exhibits double herbicidal activity of TeA. Here, this work identifies
He Wang +9 more
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Systems metabolic engineering of Corynebacterium glutamicum for efficient production of L-isoleucine [PDF]
Journal of Animal Science and BiotechnologyBackground L-Isoleucine is an essential branched-chain amino acid for livestock and poultry, supporting protein accretion and regulating energy metabolism, immune function, and stress resilience.
Junkun Cao +8 more
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The role of l-serine and l-threonine in the energy metabolism and nutritional stress response of Trypanosoma cruzi [PDF]
mSpherel-Serine and l-threonine have versatile roles in metabolism. In addition to their use in protein synthesis, these amino acids participate in the biosynthesis pathways of other amino acids and even phospholipids.
Mayke Bezerra Alencar +6 more
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Isoleucine Binding and Regulation of <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> Threonine Dehydratase (IlvA). [PDF]
BiochemistryIn , the branched-chain amino acid biosynthetic pathway provides essential intermediates for membrane biosynthesis. Threonine deaminase (IlvA) is the first enzyme in the pathway, and isoleucine feedback regulates the enzyme in . These studies on IlvA (EcIlvA) introduced the concept of allosteric regulation. To investigate the regulation of IlvA (SaIlvA)
Yun MK +5 more
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THREONINE/SERINE DEHYDRATASE ACTIVITY IN ANGIOSPERMOUS PARASITES [PDF]
New Phytologist, 1976 SummaryBoth species of broomrape tested were devoid of L‐threonine dehydratase and L‐serine dehydratase activity. When the seeds of three species of dodder were examined, threonine dehydratase activity was present in two but absent in the third. The enzyme could also not be demonstrated in the seed of a green mistletoe.
P S Krishnan
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