Results 151 to 160 of about 2,631,672 (317)
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
THRESHOLD MODELS IN THEORY AND PRACTICE
Threshold models have gained much recent attention in applied economics for modeling nonlinear behavior. The appeal for these models is due in part to the observable pattern that many economic variables follow, such as asymmetric adjustment towards ...
Gauthier, Wayne M., Zapata, Hector O.
core +1 more source
Full agreement and the provision of threshold public goods [PDF]
We report threshold public good experiments in which group members not only need to be individually willing to contribute enough to provide the public good but also have to agree with each other on what every group members should contribute.
Edward J. Cartwright, Federica Alberti
core
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Threshold concepts and metalearning capacity [PDF]
This study operationalises the empowering concept of metalearning in the specific context of engagement with a threshold concept. An experience of metalearning was constituted in two parts.
Jan H. F. Meyer +2 more
core
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
State-Dependent Threshold STAR Models [PDF]
In this paper we consider extensions of smooth transition autoregressive (STAR) models to situations where the threshold is a time-varying function of variables that affect the separation of regimes of the time series under consideration.
Michael J. Dueker +3 more
core
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Determining the Number of Regimes in a Threshold Autoregressive Model Using Smooth Transition Autoregressions [PDF]
In this paper we propose a method for determining the number of regimes in threshold autoregressive models using smooth transition autoregression as a tool.
Strikholm, Birgit, Teräsvirta, Timo
core