Results 131 to 140 of about 2,631,672 (317)

Identification of threshold concepts involved in early electronics: Some new methods and results

open access: yes, 2012
This manuscript reports the threshold concepts identified over a two-year study in early circuits and electronics courses. Some novel methods have been used to improve confidence in the identification process.
Scott, Jonathan B., Harlow, Ann
core  

Determining Effective Threshold Range of Image Pixel Values for Municipal Waste-Contaminated Clay

open access: yesApplied Sciences
Currently, more attention has been given to the study of the microstructure of contaminated clay, while few studies have focused on the analysis of SEM images of clay from a threshold perspective.
Rui Zhang, Liwen Cao, Yuliang Guo
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Threshold Concepts & Assessment

open access: yes, 2015
Powerpoint presentation about information literacy assessment in the context for the new ACRL Framework for Information Literacy and threshold concepts.
Alwan, Ahmed
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Operationalising a Threshold Concept in Economics: A Pilot Study Using Multiple Choice Questions on Opportunity Cost [PDF]

open access: yes
This paper addresses the emerging educational framework that envisions threshold concepts as mediators of learning outcomes. While the threshold concepts framework is highly appealing on a theoretical level, few researchers have attempted to measure ...
Jan H. F. Meyer   +2 more
core  

End Behavior of the Threshold Protocol Game on Complete and Bipartite Graphs

open access: yesGames
The threshold protocol game is a graphical game that models the adoption of an idea or product through a population. There are two states players may take in the game, and the goal of the game is to motivate the state that begins in the minority to ...
Alexandra Fedrigo
doaj   +1 more source

Threshold [PDF]

open access: yesCanadian Medical Association Journal, 2013
openaire   +2 more sources

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