Results 91 to 100 of about 16,597,684 (304)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Partial knowledge restrictions on the two-stage threshold model of choice [PDF]
, 2015 In the context of the two-stage threshold model of decision making, with the agent’s choices determined by the interaction of three “structural variables,” we study the restrictions on behavior that arise when one or more variables are exogenously known.
Tyson, Christopher J. +2 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Progress of the international H-mode power threshold database activity
, 2002 The International Global H-mode Threshold Database has been revised and cleaned from inadequate data for some tokamaks. This significantly reduces the scatter for the corresponding datasets.
Ryter, F. +3 more
core +1 more source
Threshold Effects in Multivariate Error Correction Models [PDF]
, 2006 We propose a testing procedure for assessing the presence of threshold effects in nonstationary vector autoregressive models with or without cointegration.
Gonzalo, Jesús, Pitarakis, Jean-Yves
core +1 more source
Journal of Dairy Science: The GEBV for health traits are typically published as probabilities obtained using threshold models. While these models benefit from theoretical properties, they require substantial computational resources and may face convergence issues. Linear models
Denyus Augusto de Oliveira Padilha +11 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Genetic parameters for pathogen-specific mastitis resistance in Danish Holstein Cattle
Animal, 2009 The objective of this study was to estimate heritabilities for and genetic correlations among different pathogen-specific mastitis traits. The traits were unspecific mastitis, which is all mastitis treatments regardless of the causative pathogen as well ...
L.P. Sørensen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Determining the Number of Regimes in a Threshold Autoregressive Model Using Smooth Transition Autoregressions [PDF]
In this paper we propose a method for determining the number of regimes in threshold autoregressive models using smooth transition autoregression as a tool.
Strikholm, Birgit, Teräsvirta, Timo
core