Results 41 to 50 of about 1,475,278 (264)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm   +11 more
wiley   +1 more source

Thresholds models of technological transitions [PDF]

open access: yesEnvironmental Innovation and Societal Transitions, 2014
We present a systematic review of seven threshold models of technological transitions from physics, biology, economics and sociology. The very same phenomenon of a technological transition can be explained by very different logics, ranging from economic explanations based on price, performance and increasing returns to alternative explanations based on
Zeppini, Paolo   +2 more
openaire   +6 more sources

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási   +14 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo   +5 more
wiley   +1 more source

A Time-Varying Coefficient Double Threshold GARCH Model with Explanatory Variables

open access: yesAxioms, 2023
In this article, we consider the nonparametric inference for the time-varying coefficient double-threshold generalized autoregressive conditional heteroscedastic models.
Tongwei Zhang   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Qualitative threshold ARCH models [PDF]

open access: yesJournal of Econometrics, 1992
The paper deals with the tradeoff between the flexibility of the conditional variance specification in terms of a given past value and the number of lags. A class of dynamic models is considered (QTARCH models) in which both the conditional mean and the conditional variance are symmetrically treated in order to discuss the possible cross-effects or ...
Gourieroux Christian, Monfort Alain
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Target Set in Threshold Models

open access: yesCoRR, 2019
Consider a graph $G$ and an initial coloring, where each node is blue or red. In each round, all nodes simultaneously update their color based on a predefined rule. In a threshold model, a node becomes blue if a certain number or fraction of its neighbors are blue and red otherwise.
openaire   +3 more sources

Effect of Urban Greening on Incremental PM2.5 Concentration During Peak Hours

open access: yesFrontiers in Public Health, 2020
In China, severe haze is a major public health concern affecting residents' health and well-being. This study used hourly air quality monitoring data from 285 cities in China to analyze the effect of green coverage (GC) and other economic variables on ...
Shaogu Wang, Shunqi Cheng, Xinhua Qi
doaj   +1 more source

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