Results 51 to 60 of about 1,475,278 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Assessing the Influence of Environmental Factors on Landslide Frequency and Intensity in Northwestern Sichuan, SW China, Using Multi-Temporal Satellite Imagery

Remote Sensing
Landslides are a significant geological hazard with substantial socio-economic and environmental consequences, particularly in northwestern Sichuan, SW China, where complex geological and climatic conditions contribute to their occurrence.
Yu Zhu, Huajin Li, Ran Tang, Zhanfeng Fan, Lixuan Mao, Yifei Lu, Chuanhao Pu, Yusen He   +7 more
doaj   +1 more source

A simulation study for the analysis of uncertain binary responses: Application to first insemination success in beef cattle

Genetics Selection Evolution, 2005
A simulation was carried out to investigate the methods of analyzing uncertain binary responses for success or failure at first insemination. A linear mixed model that included, herd, year, and month of mating as fixed effects; and unrelated service sire,
Rekaya Romdhane, Spangler Matthew L, Sapp Robyn L, Bertrand J Keith   +3 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

On buffered threshold Garch models

Statistica Sinica, 2016
published_or_final_version
LO, PH, Li, G, Yu, PLH, Li, WK
openaire   +3 more sources

Sustainable digital transformation: the nexus between ICT and global green economic growth

Technological and Economic Development of Economy
As a new engine to promote global economic and social development, information and communication technology (ICT) plays a key role in the field of modern economy.
Yiwen Li, Xia Li, Xiaojuan Wang, Chao Feng   +3 more
doaj   +1 more source

Exploration of lagged relationships between mastitis and milk yield in dairycows using a Bayesian structural equation Gaussian-threshold model

Genetics Selection Evolution, 2008
A Gaussian-threshold model is described under the general framework of structural equation models for inferring simultaneous and recursive relationships between binary and Gaussian characters, and estimating genetic parameters.
Gianola Daniel, Heringstad Bjørg, Wu Xiao-Lin   +2 more
doaj   +1 more source