Results 41 to 50 of about 109,385 (246)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Numerical Simulation of Low-Permeability Reservoirs with considering the Dynamic Boundary Layer Effect

Geofluids, 2021
Surface active components, salt component, and polar molecules in the fluid may adsorb on the solid surface and form the boundary layer during low-speed flow in a porous medium, which will influence the flowing law in the porous medium.
Chuanzhi Cui, Yingfei Sui, Xiangzhi Cheng, Yinzhu Ye, Zhen Wang   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Investigation of productivity decline in inter-salt argillaceous dolomite reservoir due to formation damage and threshold pressure gradient: Laboratory, mathematical modeling and application

Energy Exploration & Exploitation, 2017
The inter-salt argillaceous dolomite reservoirs in the central region of China contain large abundance of oil resources with ultra-low permeability and porosity.
Dan Wu, Binshan Ju, Shiqiang Wu, Eric Thompson Brantson, Yingkun Fu, Zhao Lei   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Transient transfer shape factor for fractured tight reservoirs: Effect of the dynamic threshold pressure gradient in unsteady flow

Energy Science & Engineering, 2020
In fractured tight reservoirs, the seepage capacity of the matrix is poor, and fluid migration mainly depends on matrix/fracture transfer. An accurate understanding of the matrix/fracture flow is the basis of well tests and numerical simulations for ...
Kai Liu, Daiyin Yin, Haibo Su
doaj   +1 more source

Discussion on seepage governing equations for low permeability reservoirs with a threshold pressure gradient [PDF]

Advances in Geo-Energy Research, 2018
Low permeability reservoirs account for an increasing proportion of oil production. Threshold pressure gradient is an important factor that governs the flow in low permeability porous media. The 1-D seepage governing equation (SGE) for low permeability porous media can be derived from the 1-D core flooding experimental rule.
Han, Guofeng, Liu, Yuewu, Nawnit, Kumar, Zhou, Yingfang   +3 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Analytical Model for Rate-Transient Analysis of Shale Oil Wells Considering Multiphase Flow, Threshold Pressure Gradient, and Stress Sensitivity

Energies
Shale oil reservoirs exhibit ultralow permeability and complex pore structures, which result in non-Darcy low-velocity flow and cause permeability to be stress-sensitive.
Zhen Li, Kai Xu, Ping Guo, Xiaoli Yang, Yuyi Shen, Junjie Ren   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source