Results 121 to 130 of about 1,945,580 (301)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Firing Cost and Firm Size: A Study of Sri Lanka's Severance Pay System [PDF]

Sri Lanka's Termination of Employment of Workmen Act (TEWA) requires that firms with 15 or more employees justify layoffs and provide generous severance pay to displaced workers, with smaller firms being exempted.
Abidoye, Babatunde, Orazem, Peter, Vodopivec, Milan   +2 more
core  

Development of retinal blood vessel segmentation methodology using wavelet transforms for assessment of diabetic retinopathy [PDF]

, 2005
Automated image processing has the potential to assist in the early detection of diabetes, by detecting changes in blood vessel diameter and patterns in the retina.
Bossomaier, T., Cesar, R.M., Jr., Cornforth, D.J., Cree, Michael J., Jelinek, Herbert J., Leandro, J.J.G., Mitchell, P., Soares, J.V.B.   +7 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Differential Evolution-Based Transient Search Optimizer for Image Multi-Thresholding Problem

International Journal of Computational Intelligence Systems
A significant number of image processing and evaluation processes are presented and applied, due to their practical significance, in a variety of disciplines in the literature related to image processing and computer vision.
Nitin Mittal, Supreet Singh, Lalit Kumar, Gurpreet Kaur, Vikas Mittal, A. Johnson Santhosh   +5 more
doaj   +1 more source

Binding of Object Representations by Synchronous Cortical Dynamics Explains Temporal Order and Spatial Pooling Data [PDF]

, 1994
A key problem in cognitive science concerns how the brain binds together parts of an object into a coherent visual object representation. One difficulty that this binding process needs to overcome is that different parts of an object may be processed by ...
Grossberg, Stephen, Gruenwald, Alexander
core   +2 more sources

Parameter Estimation of Threshold OU Process

WSEAS TRANSACTIONS ON BUSINESS AND ECONOMICS
This study focuses on analyzing interest rate dynamics trends in different economies. First, we derive the marginal distribution of the threshold Ornstein-Uhlenbeck (OU) process. Then, we explicitly construct its probability density function (PDF). Additionally, we use the maximum likelihood estimation (MLE) method to estimate the model parameters, as ...
Wenkai Yan, Huilin Zang, Lingyun Gao, Yaoqi Chen, Ying He, Rongna Liang, Haoyan Zhang   +6 more
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Materials processing threshold report: 2. Use of low gravity for cast iron process development [PDF]

Potential applications of a low gravity environment of interest to the commercial producers of cast iron were assessed to determine whether low gravity conditions offer potential opportunities to producers for improving cast iron properties and expanding
Frankhouser, W. L.
core   +1 more source