Results 141 to 150 of about 1,603,529 (309)

Clinical Significance of Cycle Threshold (Ct) Values for Predicting COVID-19 Patient Outcome

Canadian Journal of Infectious Diseases and Medical Microbiology
Quantitative PCR (qPCR) is a highly accurate molecular tool widely used for the diagnosis of infectious diseases, including SARS-CoV-2 infection. Among its key outputs, the Cycle Threshold (Ct) value indicates the number of amplification cycles required ...
Sergio Manuel Salas Pacheco, Sebastián Eduardo González Villarreal, Daniel Francisco Ramos Rosales, Erick Ivan Hernandez Cosain, Alma Salas Leal, Fernando Vazquez Alaniz, Omar Alejandro Tremillo Maldonado, Gamaliel Ortiz Sarabia, Ada Agustina Sandoval Carrillo, Francisco Xavier Castellanos Juarez, José Manuel Salas Pacheco, Marcelo Gomez Palacio Gastelum, Luis Javier Solís Martínez, Mónica García Montelongo   +13 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Threshold values in groundwater: for which substances?

, 2017
Drempelwaarden voor grondwater zijn verplicht door de (Europese) Kaderrichtlijn Water. Er komen geen Europese voorschriften voor de stoffen waarvoor drempelwaarden moeten worden vastgesteld, noch voor de hoogte van drempelwaarden.
Verweij W, Reijnders HFR
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Rethinking Low Handgrip Strength: Normative Values, Diagnostic Thresholds, and Sarcopenia Risk in Malaysian Older Adults

Clinical Interventions in Aging
Theng Choon Ooi,1,2 Nurul Fatin Malek Rivan,1 Suzana Shahar,1 Azianah Mohamad Ibrahim,1 Devinder Kaur Ajit Singh1 1Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala ...
Ooi TC, Rivan NFM, Shahar S, Ibrahim AM, Singh DKA   +4 more
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Graphical identification of TAR models [PDF]

This paper proposes an automatic procedure to identify Threshold Autoregressive models and specify the threshold values. The proposed procedure is based on recursive estimation of arranged autoregression. The main advantage of the proposed procedure over
Daniel Peña, Ismael Sánchez, Miguel Ángel Bermejo   +2 more
core